Whole-genome sequencing of 175 Mongolians uncovers population-specific genetic architecture and gene flow throughout North and East Asia

Haihua Bai; Xiaosen Guo; Narisu Narisu; Tianming Lan; Qizhu Wu; Yanping Xing; Yong Zhang; Stephen R. Bond; Zhili Pei; Yanru Zhang; Dandan Zhang; Jirimutu Jirimutu; Dong Zhang; Xukui Yang; Morigenbatu Morigenbatu; Li Zhang; Bingyi Ding; Baozhu Guan; Junwei Cao; Haorong Lu; Yiyi Liu; Wangsheng Li; Ningxin Dang; Mingyang Jiang; Shenyuan Wang; Huixin Xu; Dingzhu Wang; Chunxia Liu; Xin Luo; Ying Gao; Xueqiong Li; Zongze Wu; Liqing Yang; Fanhua Meng; Xiaolian Ning; Hashenqimuge Hashenqimuge; Kaifeng Wu; Bo Wang; Suyalatu Suyalatu; Yingchun Liu; Chen Ye; Huiguang Wu; Kalle Leppälä; Lu Li; Lin Fang; Yujie Chen; Wenhao Xu; Tao Li; Xin Liu; Xun Xu; Christopher R. Gignoux; Huanming Yang; Lawrence C. Brody; Jun Wang; Karsten Kristiansen; Burenbatu Burenbatu; Huanmin Zhou; Ye Yin

doi:10.1038/s41588-018-0250-5

Whole-genome sequencing of 175 Mongolians uncovers population-specific genetic architecture and gene flow throughout North and East Asia

Haihua Bai
, Xiaosen Guo
, Narisu Narisu
, Tianming Lan
, Qizhu Wu
, Yanping Xing
, Yong Zhang
, Stephen R. Bond
, Zhili Pei
, Yanru Zhang
, Dandan Zhang
, Jirimutu Jirimutu
, Dong Zhang
, Xukui Yang
, Morigenbatu Morigenbatu
, Li Zhang
, Bingyi Ding
, Baozhu Guan
, Junwei Cao
, Haorong Lu

Yiyi Liu, Wangsheng Li, Ningxin Dang, Mingyang Jiang, Shenyuan Wang, Huixin Xu, Dingzhu Wang, Chunxia Liu, Xin Luo, Ying Gao, Xueqiong Li, Zongze Wu, Liqing Yang, Fanhua Meng, Xiaolian Ning, Hashenqimuge Hashenqimuge, Kaifeng Wu, Bo Wang, Suyalatu Suyalatu, Yingchun Liu, Chen Ye, Huiguang Wu, Kalle Leppälä, Lu Li, Lin Fang, Yujie Chen, Wenhao Xu, Tao Li, Xin Liu, Xun Xu, Christopher R. Gignoux, Huanming Yang, Lawrence C. Brody, Jun Wang, Karsten Kristiansen, Burenbatu Burenbatu, Huanmin Zhou, Ye Yin

Inner Mongolia University for Nationalities
Inner Mongolia Engineering Research Center of Personalized Medicine
BGI-Shenzhen
University of Copenhagen
National Institutes of Health
Inner Mongolia Agricultural University
Inner Mongolia International Mongolian Hospital
Guangdong Provincial Key Laboratory of Genome Read and Write
Aarhus University
Huazhong Agricultural University
University of Colorado Anschutz Medical Campus
Zhejiang University
Dalian University of Technology

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52 引用（Scopus）

摘要

The genetic variation in Northern Asian populations is currently undersampled. To address this, we generated a new genetic variation reference panel by whole-genome sequencing of 175 ethnic Mongolians, representing six tribes. The cataloged variation in the panel shows strong population stratification among these tribes, which correlates with the diverse demographic histories in the region. Incorporating our results with the 1000 Genomes Project panel identifies derived alleles shared between Finns and Mongolians/Siberians, suggesting that substantial gene flow between northern Eurasian populations has occurred in the past. Furthermore, we highlight that North, East, and Southeast Asian populations are more aligned with each other than these groups are with South Asian and Oceanian populations.

源语言	英语
页（从-至）	1696-1704
页数	9
期刊	Nature Genetics
卷	50
期	12
DOI	https://doi.org/10.1038/s41588-018-0250-5
出版状态	已出版 - 1 12月 2018
已对外发布	是

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Bai, H., Guo, X., Narisu, N., Lan, T., Wu, Q., Xing, Y., Zhang, Y., Bond, S. R., Pei, Z., Zhang, Y., Zhang, D., Jirimutu, J., Zhang, D., Yang, X., Morigenbatu, M., Zhang, L., Ding, B., Guan, B., Cao, J., ... Yin, Y. (2018). Whole-genome sequencing of 175 Mongolians uncovers population-specific genetic architecture and gene flow throughout North and East Asia. Nature Genetics, 50(12), 1696-1704. https://doi.org/10.1038/s41588-018-0250-5

@article{1f0bcac568c04d0d9af1aacde2038b61,

title = "Whole-genome sequencing of 175 Mongolians uncovers population-specific genetic architecture and gene flow throughout North and East Asia",

abstract = "The genetic variation in Northern Asian populations is currently undersampled. To address this, we generated a new genetic variation reference panel by whole-genome sequencing of 175 ethnic Mongolians, representing six tribes. The cataloged variation in the panel shows strong population stratification among these tribes, which correlates with the diverse demographic histories in the region. Incorporating our results with the 1000 Genomes Project panel identifies derived alleles shared between Finns and Mongolians/Siberians, suggesting that substantial gene flow between northern Eurasian populations has occurred in the past. Furthermore, we highlight that North, East, and Southeast Asian populations are more aligned with each other than these groups are with South Asian and Oceanian populations.",

author = "Haihua Bai and Xiaosen Guo and Narisu Narisu and Tianming Lan and Qizhu Wu and Yanping Xing and Yong Zhang and Bond, \{Stephen R.\} and Zhili Pei and Yanru Zhang and Dandan Zhang and Jirimutu Jirimutu and Dong Zhang and Xukui Yang and Morigenbatu Morigenbatu and Li Zhang and Bingyi Ding and Baozhu Guan and Junwei Cao and Haorong Lu and Yiyi Liu and Wangsheng Li and Ningxin Dang and Mingyang Jiang and Shenyuan Wang and Huixin Xu and Dingzhu Wang and Chunxia Liu and Xin Luo and Ying Gao and Xueqiong Li and Zongze Wu and Liqing Yang and Fanhua Meng and Xiaolian Ning and Hashenqimuge Hashenqimuge and Kaifeng Wu and Bo Wang and Suyalatu Suyalatu and Yingchun Liu and Chen Ye and Huiguang Wu and Kalle Lepp{\"a}l{\"a} and Lu Li and Lin Fang and Yujie Chen and Wenhao Xu and Tao Li and Xin Liu and Xun Xu and Gignoux, \{Christopher R.\} and Huanming Yang and Brody, \{Lawrence C.\} and Jun Wang and Karsten Kristiansen and Burenbatu Burenbatu and Huanmin Zhou and Ye Yin",

note = "Publisher Copyright: {\textcopyright} 2018, The Author(s), under exclusive licence to Springer Nature America, Inc.",

year = "2018",

month = dec,

day = "1",

doi = "10.1038/s41588-018-0250-5",

language = "英语",

volume = "50",

pages = "1696--1704",

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Bai, H, Guo, X, Narisu, N, Lan, T, Wu, Q, Xing, Y, Zhang, Y, Bond, SR, Pei, Z, Zhang, Y, Zhang, D, Jirimutu, J, Zhang, D, Yang, X, Morigenbatu, M, Zhang, L, Ding, B, Guan, B, Cao, J, Lu, H, Liu, Y, Li, W, Dang, N, Jiang, M, Wang, S, Xu, H, Wang, D, Liu, C, Luo, X, Gao, Y, Li, X, Wu, Z, Yang, L, Meng, F, Ning, X, Hashenqimuge, H, Wu, K, Wang, B, Suyalatu, S, Liu, Y, Ye, C, Wu, H, Leppälä, K, Li, L, Fang, L, Chen, Y, Xu, W, Li, T, Liu, X, Xu, X, Gignoux, CR, Yang, H, Brody, LC, Wang, J, Kristiansen, K, Burenbatu, B, Zhou, H & Yin, Y 2018, 'Whole-genome sequencing of 175 Mongolians uncovers population-specific genetic architecture and gene flow throughout North and East Asia', Nature Genetics, 卷 50, 号码 12, 页码 1696-1704. https://doi.org/10.1038/s41588-018-0250-5

TY - JOUR

T1 - Whole-genome sequencing of 175 Mongolians uncovers population-specific genetic architecture and gene flow throughout North and East Asia

AU - Bai, Haihua

AU - Guo, Xiaosen

AU - Narisu, Narisu

AU - Lan, Tianming

AU - Wu, Qizhu

AU - Xing, Yanping

AU - Zhang, Yong

AU - Bond, Stephen R.

AU - Pei, Zhili

AU - Zhang, Yanru

AU - Zhang, Dandan

AU - Jirimutu, Jirimutu

AU - Zhang, Dong

AU - Yang, Xukui

AU - Morigenbatu, Morigenbatu

AU - Zhang, Li

AU - Ding, Bingyi

AU - Guan, Baozhu

AU - Cao, Junwei

AU - Lu, Haorong

AU - Liu, Yiyi

AU - Li, Wangsheng

AU - Dang, Ningxin

AU - Jiang, Mingyang

AU - Wang, Shenyuan

AU - Xu, Huixin

AU - Wang, Dingzhu

AU - Liu, Chunxia

AU - Luo, Xin

AU - Gao, Ying

AU - Li, Xueqiong

AU - Wu, Zongze

AU - Yang, Liqing

AU - Meng, Fanhua

AU - Ning, Xiaolian

AU - Hashenqimuge, Hashenqimuge

AU - Wu, Kaifeng

AU - Wang, Bo

AU - Suyalatu, Suyalatu

AU - Liu, Yingchun

AU - Ye, Chen

AU - Wu, Huiguang

AU - Leppälä, Kalle

AU - Li, Lu

AU - Fang, Lin

AU - Chen, Yujie

AU - Xu, Wenhao

AU - Li, Tao

AU - Liu, Xin

AU - Xu, Xun

AU - Gignoux, Christopher R.

AU - Yang, Huanming

AU - Brody, Lawrence C.

AU - Wang, Jun

AU - Kristiansen, Karsten

AU - Burenbatu, Burenbatu

AU - Zhou, Huanmin

AU - Yin, Ye

PY - 2018/12/1

Y1 - 2018/12/1

N2 - The genetic variation in Northern Asian populations is currently undersampled. To address this, we generated a new genetic variation reference panel by whole-genome sequencing of 175 ethnic Mongolians, representing six tribes. The cataloged variation in the panel shows strong population stratification among these tribes, which correlates with the diverse demographic histories in the region. Incorporating our results with the 1000 Genomes Project panel identifies derived alleles shared between Finns and Mongolians/Siberians, suggesting that substantial gene flow between northern Eurasian populations has occurred in the past. Furthermore, we highlight that North, East, and Southeast Asian populations are more aligned with each other than these groups are with South Asian and Oceanian populations.

AB - The genetic variation in Northern Asian populations is currently undersampled. To address this, we generated a new genetic variation reference panel by whole-genome sequencing of 175 ethnic Mongolians, representing six tribes. The cataloged variation in the panel shows strong population stratification among these tribes, which correlates with the diverse demographic histories in the region. Incorporating our results with the 1000 Genomes Project panel identifies derived alleles shared between Finns and Mongolians/Siberians, suggesting that substantial gene flow between northern Eurasian populations has occurred in the past. Furthermore, we highlight that North, East, and Southeast Asian populations are more aligned with each other than these groups are with South Asian and Oceanian populations.

UR - https://www.scopus.com/pages/publications/85056152615

U2 - 10.1038/s41588-018-0250-5

DO - 10.1038/s41588-018-0250-5

M3 - 文章

C2 - 30397334

AN - SCOPUS:85056152615

SN - 1061-4036

VL - 50

SP - 1696

EP - 1704

JO - Nature Genetics

JF - Nature Genetics

IS - 12

ER -

Whole-genome sequencing of 175 Mongolians uncovers population-specific genetic architecture and gene flow throughout North and East Asia

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