Visible-Light Photoredox-Catalyzed Hydrodecarboxylation and Deuterodecarboxylation of Fatty Acids

We develop an efficient visible-light photoreodox-catalyzed hydrodecarboxylation and deuterodecarboxylation of fatty acids for alkanes and deuterium alkanes. The key to the efficient transformation should attribute to the co-catalysis of the suitable methoxy substituted acridine photocatalyst (Mes-1,3,6,8-tetramethoxy-Acr-3”,5”-dimethoxy-Ph) and the hydrogen atom transfer catalyst 4′,4′-dimethyl diphenyldisulfane, possibly via facilitating of quenching the active alkyl radicals to overcome the competitive homocoupling products, olefins via the disproportionation, cracking products via the C—C bond β-scission.