Validation the haplotype polymorphisms of the DXS7424-DXS101 on X-chromosome

OBJECTIVE: To validate the genetic characteristics and distribution of DXS7424-DXS101 on X chromosome in Han population. METHODS: DXS7424 and DXS101 loci were genotyped by PCR, PAGE and silvers stain methods. Their genetic parameters were analyzed by Arlequin software. RESULTS: There were 37 haplotypes detected in 151 Han unrelated males. The frequencies ranged from 0.0066 to 0.1391, with a GD value of 0.9453 and a DP value of 0.9389. Haplotypes 16-23 were the most common haplotypes in Han population. CONCLUSION: Analysis of combined DXS7424 and DXS101 haplotypes appears to be a powerful means in population genetics and forensic practice for determination of identity and paternity.