Vaginal primary malignant melanoma complicating cervical carcinoma in situ: A case report and review of literature

Vaginal primary malignant melanoma (VPMM) is a rare and extremely aggressive tumor. Because of hidden location and lack of early symptoms, it usually develops at advanced stage and has very high mortality rate. Moreover, the etiology of this tumor is largely unknown. Therefore, it is important for improving prognosis to early diagnosis of VPMM. In the present study, we describe a 35-year-old female patient who was diagnosed as VPMM combined with CIN3 before any report not mentioned. The patient presented to our hospital with abnormal vaginal bleeding of 2 months. Preoperative colposcopic-directed biopsy and physical examination suggested malignant lesions occurred in the upper third of anterior vaginal wall. Then a wide local excision of the lesion was first performed. Postoperative pathological results confirmed and metastasis to left internal iliac lymphnodes. She underwent adjuvant radiotherapy and immunotherapy as further therapeutic measures. Although the patient could not complete a cycle due to intolerable toxicity of immunotherapy, she is still alive 14 months after diagnose.