TY - JOUR
T1 - Transparent ultrasonic transducers based on relaxor ferroelectric crystals for advanced photoacoustic imaging
AU - Qiu, Chaorui
AU - Zhang, Zhiqiang
AU - Xu, Zhiqiang
AU - Qiao, Liao
AU - Ning, Li
AU - Zhang, Shujun
AU - Su, Min
AU - Wu, Weichang
AU - Song, Kexin
AU - Xu, Zhuo
AU - Chen, Long Qing
AU - Zheng, Hairong
AU - Liu, Chengbo
AU - Qiu, Weibao
AU - Li, Fei
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/12
Y1 - 2024/12
N2 - Photoacoustic imaging is a promising non-invasive functional imaging modality for fundamental research and clinical diagnosis. However, achieving capillary-level resolution, wide field-of-view, and high frame rates remains challenging. To address this, we propose a transparent ultrasonic transducer design using our developed transparent Pb(In1/2Nb1/2)O3-Pb(Mg1/3Nb2/3)O3-PbTiO3 crystals. Our fabrication technique incorporates quartz-glass-and-epoxy matching layers with low-resistance indium-tin-oxide electrodes through a brass-ring based structure, enabling a high frequency (28.5 MHz), wide bandwidth (78%), and enhanced pulse-echo sensitivity (2.5 V under 2-μJ pulse excitation). Our Pb(In1/2Nb1/2)O3-Pb(Mg1/3Nb2/3)O3-PbTiO3-based transparent ultrasonic transducer demonstrates a four-fold enhancement in photoacoustic detection sensitivity when compared to the LiNbO3-based counterpart, leading to a 13 dB improvement of signal-to-noise ratio in microvascular photoacoustic imaging. This enables dynamic monitoring of mouse cerebral cortex microvasculature during seizures at 0.8 Hz frame rates over a 1.5 × 1.5 mm2 field-of-view. Our work paves the way for high-performance and compact photoacoustic imaging systems using advanced piezoelectric materials.
AB - Photoacoustic imaging is a promising non-invasive functional imaging modality for fundamental research and clinical diagnosis. However, achieving capillary-level resolution, wide field-of-view, and high frame rates remains challenging. To address this, we propose a transparent ultrasonic transducer design using our developed transparent Pb(In1/2Nb1/2)O3-Pb(Mg1/3Nb2/3)O3-PbTiO3 crystals. Our fabrication technique incorporates quartz-glass-and-epoxy matching layers with low-resistance indium-tin-oxide electrodes through a brass-ring based structure, enabling a high frequency (28.5 MHz), wide bandwidth (78%), and enhanced pulse-echo sensitivity (2.5 V under 2-μJ pulse excitation). Our Pb(In1/2Nb1/2)O3-Pb(Mg1/3Nb2/3)O3-PbTiO3-based transparent ultrasonic transducer demonstrates a four-fold enhancement in photoacoustic detection sensitivity when compared to the LiNbO3-based counterpart, leading to a 13 dB improvement of signal-to-noise ratio in microvascular photoacoustic imaging. This enables dynamic monitoring of mouse cerebral cortex microvasculature during seizures at 0.8 Hz frame rates over a 1.5 × 1.5 mm2 field-of-view. Our work paves the way for high-performance and compact photoacoustic imaging systems using advanced piezoelectric materials.
UR - https://www.scopus.com/pages/publications/85211369169
U2 - 10.1038/s41467-024-55032-0
DO - 10.1038/s41467-024-55032-0
M3 - 文章
C2 - 39632872
AN - SCOPUS:85211369169
SN - 2041-1723
VL - 15
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 10580
ER -