Trace Detection of Staphylococcal Enterotoxin B Based on Hydrogen-Terminated Diamond Solution-Gate Field-Effect Transistor

Yuxiang Du; Qingyu Lv; Yongqiang Jiang; Wei Wang; Genqiang Chen; Xiaofan Zhang; Yuesong Liang; Huiqi Duan; Yuhao Ren; Minghui Zhang; Shaolong Chen; Hongxing Wang

doi:10.1021/acs.analchem.5c04340

Trace Detection of Staphylococcal Enterotoxin B Based on Hydrogen-Terminated Diamond Solution-Gate Field-Effect Transistor

Yuxiang Du
, Qingyu Lv
, Yongqiang Jiang
, Wei Wang
, Genqiang Chen
, Xiaofan Zhang
, Yuesong Liang
, Huiqi Duan
, Yuhao Ren
, Minghui Zhang
, Shaolong Chen
, Hongxing Wang

电子与信息学部

Xi'an Jiaotong University
Academy of Military Medical Science China

科研成果: 期刊稿件 › 文章 › 同行评审

1 引用（Scopus）

摘要

Staphylococcal enterotoxin B is the most hazardous of the various toxins produced by Staphylococcus aureus. Thus, trace detection of SEB is essential for prevention, diagnosis, and treatment. In this work, an electrochemical platform was constructed to detect SEB based on a hydrogen-terminated diamond solution-gate field-effect transistor. The connection of 1-pyrenebutyric acid-N-hydroxy succinimide ester and anti-SEB antibody on the sensing area was confirmed by atomic force microscopy, scanning electron microscopy, and X-ray photoelectron spectroscopy. Output and transfer characteristics of the device were investigated, which obtained a wide linear response from 10^–15to 10^–7g/mL, a high sensitivity of −49.37 mV/lg [SEB concentration], and a low detection limitation of 10^–15g/mL.

源语言	英语
页（从-至）	21799-21804
页数	6
期刊	Analytical Chemistry
卷	97
期	40
DOI	https://doi.org/10.1021/acs.analchem.5c04340
出版状态	已出版 - 14 10月 2025

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10.1021/acs.analchem.5c04340

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title = "Trace Detection of Staphylococcal Enterotoxin B Based on Hydrogen-Terminated Diamond Solution-Gate Field-Effect Transistor",

abstract = "Staphylococcal enterotoxin B is the most hazardous of the various toxins produced by Staphylococcus aureus. Thus, trace detection of SEB is essential for prevention, diagnosis, and treatment. In this work, an electrochemical platform was constructed to detect SEB based on a hydrogen-terminated diamond solution-gate field-effect transistor. The connection of 1-pyrenebutyric acid-N-hydroxy succinimide ester and anti-SEB antibody on the sensing area was confirmed by atomic force microscopy, scanning electron microscopy, and X-ray photoelectron spectroscopy. Output and transfer characteristics of the device were investigated, which obtained a wide linear response from 10–15to 10–7g/mL, a high sensitivity of −49.37 mV/lg [SEB concentration], and a low detection limitation of 10–15g/mL.",

author = "Yuxiang Du and Qingyu Lv and Yongqiang Jiang and Wei Wang and Genqiang Chen and Xiaofan Zhang and Yuesong Liang and Huiqi Duan and Yuhao Ren and Minghui Zhang and Shaolong Chen and Hongxing Wang",

note = "Publisher Copyright: {\textcopyright} 2025 American Chemical Society",

year = "2025",

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day = "14",

doi = "10.1021/acs.analchem.5c04340",

language = "英语",

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TY - JOUR

T1 - Trace Detection of Staphylococcal Enterotoxin B Based on Hydrogen-Terminated Diamond Solution-Gate Field-Effect Transistor

AU - Du, Yuxiang

AU - Lv, Qingyu

AU - Jiang, Yongqiang

AU - Wang, Wei

AU - Chen, Genqiang

AU - Zhang, Xiaofan

AU - Liang, Yuesong

AU - Duan, Huiqi

AU - Ren, Yuhao

AU - Zhang, Minghui

AU - Chen, Shaolong

AU - Wang, Hongxing

PY - 2025/10/14

Y1 - 2025/10/14

N2 - Staphylococcal enterotoxin B is the most hazardous of the various toxins produced by Staphylococcus aureus. Thus, trace detection of SEB is essential for prevention, diagnosis, and treatment. In this work, an electrochemical platform was constructed to detect SEB based on a hydrogen-terminated diamond solution-gate field-effect transistor. The connection of 1-pyrenebutyric acid-N-hydroxy succinimide ester and anti-SEB antibody on the sensing area was confirmed by atomic force microscopy, scanning electron microscopy, and X-ray photoelectron spectroscopy. Output and transfer characteristics of the device were investigated, which obtained a wide linear response from 10–15to 10–7g/mL, a high sensitivity of −49.37 mV/lg [SEB concentration], and a low detection limitation of 10–15g/mL.

AB - Staphylococcal enterotoxin B is the most hazardous of the various toxins produced by Staphylococcus aureus. Thus, trace detection of SEB is essential for prevention, diagnosis, and treatment. In this work, an electrochemical platform was constructed to detect SEB based on a hydrogen-terminated diamond solution-gate field-effect transistor. The connection of 1-pyrenebutyric acid-N-hydroxy succinimide ester and anti-SEB antibody on the sensing area was confirmed by atomic force microscopy, scanning electron microscopy, and X-ray photoelectron spectroscopy. Output and transfer characteristics of the device were investigated, which obtained a wide linear response from 10–15to 10–7g/mL, a high sensitivity of −49.37 mV/lg [SEB concentration], and a low detection limitation of 10–15g/mL.

UR - https://www.scopus.com/pages/publications/105018576856

U2 - 10.1021/acs.analchem.5c04340

DO - 10.1021/acs.analchem.5c04340

M3 - 文章

AN - SCOPUS:105018576856

SN - 0003-2700

VL - 97

SP - 21799

EP - 21804

JO - Analytical Chemistry

JF - Analytical Chemistry

IS - 40

ER -

Trace Detection of Staphylococcal Enterotoxin B Based on Hydrogen-Terminated Diamond Solution-Gate Field-Effect Transistor

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