TY - JOUR
T1 - Three-Dimensional sp2 Carbon-Linked Covalent Organic Frameworks as a Drug Carrier Combined with Fluorescence Imaging
AU - Liao, Li
AU - Zhang, Zerong
AU - Guan, Xinyu
AU - Li, Hui
AU - Liu, Yaozu
AU - Zhang, Minghao
AU - Tang, Bin
AU - Valtchev, Valentin
AU - Yan, Yushan
AU - Qiu, Shilun
AU - Yao, Xiangdong
AU - Fang, Qianrong
N1 - Publisher Copyright:
© 2022 SIOC, CAS, Shanghai, & WILEY-VCH GmbH.
PY - 2022/9/1
Y1 - 2022/9/1
N2 - Three-dimensional (3D) covalent organic frameworks (COFs) are crystalline porous polymers with potential in numerous high-tech applications, but the linkages involved in their synthesis are still rather limited. Herein, we report novel 3D sp2 carbon-linked COFs fabricated by the formation reaction of C=C bonds and their application in fluorescence imaging. These new COFs, namely JUC-580 and JUC-581, show high stability and excellent light-emitting properties in solid state and dispersed in various solvents. Furthermore, we investigate the potential application of JUC-581 as a drug carrier combined with fluorescence imaging. These results indicate that 3D sp2 carbon-linked COFs are not only potential drug-loaded and sustained release materials but also promising cell fluorescent stains. This study thus expands the structural categories of 3D COFs based on different linkages, and promotes their prospective applications for biomedicine and fluorescent materials.
AB - Three-dimensional (3D) covalent organic frameworks (COFs) are crystalline porous polymers with potential in numerous high-tech applications, but the linkages involved in their synthesis are still rather limited. Herein, we report novel 3D sp2 carbon-linked COFs fabricated by the formation reaction of C=C bonds and their application in fluorescence imaging. These new COFs, namely JUC-580 and JUC-581, show high stability and excellent light-emitting properties in solid state and dispersed in various solvents. Furthermore, we investigate the potential application of JUC-581 as a drug carrier combined with fluorescence imaging. These results indicate that 3D sp2 carbon-linked COFs are not only potential drug-loaded and sustained release materials but also promising cell fluorescent stains. This study thus expands the structural categories of 3D COFs based on different linkages, and promotes their prospective applications for biomedicine and fluorescent materials.
KW - Covalent organic frameworks
KW - Crystalline porous materials
KW - Drug delivery
KW - Fluorescence imaging
KW - Microporous materials
UR - https://www.scopus.com/pages/publications/85132341232
U2 - 10.1002/cjoc.202200194
DO - 10.1002/cjoc.202200194
M3 - 文章
AN - SCOPUS:85132341232
SN - 1001-604X
VL - 40
SP - 2081
EP - 2088
JO - Chinese Journal of Chemistry
JF - Chinese Journal of Chemistry
IS - 17
ER -