The protective effect of 3,6-dimethamidodibenzopyriodonium gluconate on myocardial ischemic-reperfused injury in rats

Xikuan Li; Wei Gou; Xiaolian Shi; Juntian Liu; Xiuling Deng; Xiaoming Sun; Weiguo Bian; Zijie Hou

The protective effect of 3,6-dimethamidodibenzopyriodonium gluconate on myocardial ischemic-reperfused injury in rats

Xikuan Li
, Wei Gou
, Xiaolian Shi
, Juntian Liu
, Xiuling Deng
, Xiaoming Sun
, Weiguo Bian
, Zijie Hou

医学部

Xi'an Jiaotong University

科研成果: 期刊稿件 › 文章 › 同行评审

摘要

Objective: To observe the effect of IHC-93 on myocardial ischemic-reperfused injury in rats. Methods: The injury model was produced by the ligation of descending anterior branch of the left coronary artery. Results: The study showed that IHC-93 at the dose of 0.125, 0.25 and 0.5 mg·kg^-1 reduced the area of acute myocardial infarction caused by myocardial ischemia and reperfusion, reduced creatine phosphokinase (CK) and creatine phosphokinase isoenzyme (CK-MB) levels in serum. IHC-93 also diminished ET-1 in myocardium and myocardial edema. Conclusion: IHC-93 can exerta significantly protective effect on myocardial ischemic-reperfused injury in rats.

源语言	英语
页（从-至）	425-427
页数	3
期刊	Journal of Xi'an Jiaotong University (Medical Sciences)
卷	23
期	5
出版状态	已出版 - 10月 2002

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引用此

@article{fa995efff0a4448cb92c067334eceabf,

title = "The protective effect of 3,6-dimethamidodibenzopyriodonium gluconate on myocardial ischemic-reperfused injury in rats",

abstract = "Objective: To observe the effect of IHC-93 on myocardial ischemic-reperfused injury in rats. Methods: The injury model was produced by the ligation of descending anterior branch of the left coronary artery. Results: The study showed that IHC-93 at the dose of 0.125, 0.25 and 0.5 mg·kg-1 reduced the area of acute myocardial infarction caused by myocardial ischemia and reperfusion, reduced creatine phosphokinase (CK) and creatine phosphokinase isoenzyme (CK-MB) levels in serum. IHC-93 also diminished ET-1 in myocardium and myocardial edema. Conclusion: IHC-93 can exerta significantly protective effect on myocardial ischemic-reperfused injury in rats.",

keywords = "3,6-dimethamidodibenzopyriodonium gluconate, Creatine phosphokinase, Creatine phosphokinase isoenzyme, Endothelin, Ischemic-reperfused injury",

author = "Xikuan Li and Wei Gou and Xiaolian Shi and Juntian Liu and Xiuling Deng and Xiaoming Sun and Weiguo Bian and Zijie Hou",

year = "2002",

month = oct,

language = "英语",

volume = "23",

pages = "425--427",

journal = "Journal of Xi'an Jiaotong University (Medical Sciences)",

issn = "1671-8259",

publisher = "Xi'an Medical University",

number = "5",

}

TY - JOUR

T1 - The protective effect of 3,6-dimethamidodibenzopyriodonium gluconate on myocardial ischemic-reperfused injury in rats

AU - Li, Xikuan

AU - Gou, Wei

AU - Shi, Xiaolian

AU - Liu, Juntian

AU - Deng, Xiuling

AU - Sun, Xiaoming

AU - Bian, Weiguo

AU - Hou, Zijie

PY - 2002/10

Y1 - 2002/10

N2 - Objective: To observe the effect of IHC-93 on myocardial ischemic-reperfused injury in rats. Methods: The injury model was produced by the ligation of descending anterior branch of the left coronary artery. Results: The study showed that IHC-93 at the dose of 0.125, 0.25 and 0.5 mg·kg-1 reduced the area of acute myocardial infarction caused by myocardial ischemia and reperfusion, reduced creatine phosphokinase (CK) and creatine phosphokinase isoenzyme (CK-MB) levels in serum. IHC-93 also diminished ET-1 in myocardium and myocardial edema. Conclusion: IHC-93 can exerta significantly protective effect on myocardial ischemic-reperfused injury in rats.

AB - Objective: To observe the effect of IHC-93 on myocardial ischemic-reperfused injury in rats. Methods: The injury model was produced by the ligation of descending anterior branch of the left coronary artery. Results: The study showed that IHC-93 at the dose of 0.125, 0.25 and 0.5 mg·kg-1 reduced the area of acute myocardial infarction caused by myocardial ischemia and reperfusion, reduced creatine phosphokinase (CK) and creatine phosphokinase isoenzyme (CK-MB) levels in serum. IHC-93 also diminished ET-1 in myocardium and myocardial edema. Conclusion: IHC-93 can exerta significantly protective effect on myocardial ischemic-reperfused injury in rats.

KW - 3,6-dimethamidodibenzopyriodonium gluconate

KW - Creatine phosphokinase

KW - Creatine phosphokinase isoenzyme

KW - Endothelin

KW - Ischemic-reperfused injury

UR - https://www.scopus.com/pages/publications/0037594451

M3 - 文章

AN - SCOPUS:0037594451

SN - 1671-8259

VL - 23

SP - 425

EP - 427

JO - Journal of Xi'an Jiaotong University (Medical Sciences)

JF - Journal of Xi'an Jiaotong University (Medical Sciences)

IS - 5

ER -

The protective effect of 3,6-dimethamidodibenzopyriodonium gluconate on myocardial ischemic-reperfused injury in rats

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