The effect of transforming growth factor-β1 on expression of SMAD3 and SMAD7 in keloid-derived fibroblasts

Li Yang; Huiyuan Li; Shuzhong Guo; Yan Han; Suyang Tang; Linxi Zhang; Maoguo Shu; Baohua Pan

The effect of transforming growth factor-β₁ on expression of SMAD3 and SMAD7 in keloid-derived fibroblasts

Li Yang
, Huiyuan Li
, Shuzhong Guo
, Yan Han
, Suyang Tang
, Linxi Zhang
, Maoguo Shu
, Baohua Pan

Xijing Hospital

科研成果: 期刊稿件 › 文章 › 同行评审

3 引用（Scopus）

摘要

Aim: To study the expression of SMAD3 and SMAD7 of transforming growth factor-β₁ (TGF-β₁) on keloid-derived fibroblasts. Methods: The expression of SMAD3 (at 1, 2, 4, 24, 48 h) and SMAD7 (at 0.5 1, 1.5, 2, 4, 24 h) were detected by using methods of Western blot after 500 pmol/L TGF-β1 were added to the monolayer culture system. Results: The level of SMAD3 were down regulated at 24 h and the SMAD7 were maximum up regulated at 4 h when TGF-β ₁ were used. Conclusion: TGF-β₁ may down regulate the expression of SMAD3, but up regulate that of SMAD7.

源语言	英语
页（从-至）	1006-1007
页数	2
期刊	Chinese Journal of Clinical Rehabilitation
卷	7
期	6
出版状态	已出版 - 3月 2003
已对外发布	是

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引用此

@article{69848d2476e74c49b2a8a4486ead17f7,

title = "The effect of transforming growth factor-β1 on expression of SMAD3 and SMAD7 in keloid-derived fibroblasts",

abstract = "Aim: To study the expression of SMAD3 and SMAD7 of transforming growth factor-β1 (TGF-β1) on keloid-derived fibroblasts. Methods: The expression of SMAD3 (at 1, 2, 4, 24, 48 h) and SMAD7 (at 0.5 1, 1.5, 2, 4, 24 h) were detected by using methods of Western blot after 500 pmol/L TGF-β1 were added to the monolayer culture system. Results: The level of SMAD3 were down regulated at 24 h and the SMAD7 were maximum up regulated at 4 h when TGF-β 1 were used. Conclusion: TGF-β1 may down regulate the expression of SMAD3, but up regulate that of SMAD7.",

keywords = "Fibroblasts, Keloid, Transforming growth factor bata",

author = "Li Yang and Huiyuan Li and Shuzhong Guo and Yan Han and Suyang Tang and Linxi Zhang and Maoguo Shu and Baohua Pan",

year = "2003",

month = mar,

language = "英语",

volume = "7",

pages = "1006--1007",

journal = "Chinese Journal of Clinical Rehabilitation",

issn = "1671-5926",

publisher = "Publishing House of Chinese Journal of Tissue Engineering Research",

number = "6",

}

TY - JOUR

T1 - The effect of transforming growth factor-β1 on expression of SMAD3 and SMAD7 in keloid-derived fibroblasts

AU - Yang, Li

AU - Li, Huiyuan

AU - Guo, Shuzhong

AU - Han, Yan

AU - Tang, Suyang

AU - Zhang, Linxi

AU - Shu, Maoguo

AU - Pan, Baohua

PY - 2003/3

Y1 - 2003/3

N2 - Aim: To study the expression of SMAD3 and SMAD7 of transforming growth factor-β1 (TGF-β1) on keloid-derived fibroblasts. Methods: The expression of SMAD3 (at 1, 2, 4, 24, 48 h) and SMAD7 (at 0.5 1, 1.5, 2, 4, 24 h) were detected by using methods of Western blot after 500 pmol/L TGF-β1 were added to the monolayer culture system. Results: The level of SMAD3 were down regulated at 24 h and the SMAD7 were maximum up regulated at 4 h when TGF-β 1 were used. Conclusion: TGF-β1 may down regulate the expression of SMAD3, but up regulate that of SMAD7.

AB - Aim: To study the expression of SMAD3 and SMAD7 of transforming growth factor-β1 (TGF-β1) on keloid-derived fibroblasts. Methods: The expression of SMAD3 (at 1, 2, 4, 24, 48 h) and SMAD7 (at 0.5 1, 1.5, 2, 4, 24 h) were detected by using methods of Western blot after 500 pmol/L TGF-β1 were added to the monolayer culture system. Results: The level of SMAD3 were down regulated at 24 h and the SMAD7 were maximum up regulated at 4 h when TGF-β 1 were used. Conclusion: TGF-β1 may down regulate the expression of SMAD3, but up regulate that of SMAD7.

KW - Fibroblasts

KW - Keloid

KW - Transforming growth factor bata

UR - https://www.scopus.com/pages/publications/2442575699

M3 - 文章

AN - SCOPUS:2442575699

SN - 1671-5926

VL - 7

SP - 1006

EP - 1007

JO - Chinese Journal of Clinical Rehabilitation

JF - Chinese Journal of Clinical Rehabilitation

IS - 6

ER -

The effect of transforming growth factor-β1 on expression of SMAD3 and SMAD7 in keloid-derived fibroblasts

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The effect of transforming growth factor-β₁ on expression of SMAD3 and SMAD7 in keloid-derived fibroblasts