The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching

Junji Xu; Peter Zanvit; Lei Hu; Pang Yen Tseng; Na Liu; Fu Wang; Ousheng Liu; Dunfang Zhang; Wenwen Jin; Nancy Guo; Yichen Han; Jessica Yin; Alexander Cain; Mark A. Hoon; Songlin Wang; Wan Jun Chen

doi:10.1016/j.immuni.2020.06.023

The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching

Junji Xu
, Peter Zanvit
, Lei Hu
, Pang Yen Tseng
, Na Liu
, Fu Wang
, Ousheng Liu
, Dunfang Zhang
, Wenwen Jin
, Nancy Guo
, Yichen Han
, Jessica Yin
, Alexander Cain
, Mark A. Hoon
, Songlin Wang
, Wan Jun Chen

医学部

科研成果: 期刊稿件 › 文章 › 同行评审

101 引用（Scopus）

摘要

Xu et al. find that TGF-β, produced as part of the wound healing process, induces expression of interleukin-31 by dermal conventional type 2 DCs, which, in turn, increases neuron sensitivity and provokes itching.

源语言	英语
页（从-至）	371-383.e5
期刊	Immunity
卷	53
期	2
DOI	https://doi.org/10.1016/j.immuni.2020.06.023
出版状态	已出版 - 18 8月 2020

联合国可持续发展目标

此成果有助于实现下列可持续发展目标：

可持续发展目标 3 良好健康与福祉

访问文件

10.1016/j.immuni.2020.06.023

其它文件与链接

链接到 Scopus 的出版物

引用此

Xu, J., Zanvit, P., Hu, L., Tseng, P. Y., Liu, N., Wang, F., Liu, O., Zhang, D., Jin, W., Guo, N., Han, Y., Yin, J., Cain, A., Hoon, M. A., Wang, S., & Chen, W. J. (2020). The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching. Immunity, 53(2), 371-383.e5. https://doi.org/10.1016/j.immuni.2020.06.023

@article{9e9e3b38683048c29c269f8865654890,

title = "The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching",

abstract = "Xu et al. find that TGF-β, produced as part of the wound healing process, induces expression of interleukin-31 by dermal conventional type 2 DCs, which, in turn, increases neuron sensitivity and provokes itching.",

keywords = "dermal dendritic cells, interleukin-31, itch, neuro-immune interaction, transforming growth factor beta, wound healing",

author = "Junji Xu and Peter Zanvit and Lei Hu and Tseng, \{Pang Yen\} and Na Liu and Fu Wang and Ousheng Liu and Dunfang Zhang and Wenwen Jin and Nancy Guo and Yichen Han and Jessica Yin and Alexander Cain and Hoon, \{Mark A.\} and Songlin Wang and Chen, \{Wan Jun\}",

note = "Publisher Copyright: {\textcopyright} 2020",

year = "2020",

month = aug,

day = "18",

doi = "10.1016/j.immuni.2020.06.023",

language = "英语",

volume = "53",

pages = "371--383.e5",

journal = "Immunity",

issn = "1074-7613",

publisher = "Cell Press",

number = "2",

}

Xu, J, Zanvit, P, Hu, L, Tseng, PY, Liu, N, Wang, F, Liu, O, Zhang, D, Jin, W, Guo, N, Han, Y, Yin, J, Cain, A, Hoon, MA, Wang, S & Chen, WJ 2020, 'The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching', Immunity, 卷 53, 号码 2, 页码 371-383.e5. https://doi.org/10.1016/j.immuni.2020.06.023

TY - JOUR

T1 - The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching

AU - Xu, Junji

AU - Zanvit, Peter

AU - Hu, Lei

AU - Tseng, Pang Yen

AU - Liu, Na

AU - Wang, Fu

AU - Liu, Ousheng

AU - Zhang, Dunfang

AU - Jin, Wenwen

AU - Guo, Nancy

AU - Han, Yichen

AU - Yin, Jessica

AU - Cain, Alexander

AU - Hoon, Mark A.

AU - Wang, Songlin

AU - Chen, Wan Jun

PY - 2020/8/18

Y1 - 2020/8/18

N2 - Xu et al. find that TGF-β, produced as part of the wound healing process, induces expression of interleukin-31 by dermal conventional type 2 DCs, which, in turn, increases neuron sensitivity and provokes itching.

AB - Xu et al. find that TGF-β, produced as part of the wound healing process, induces expression of interleukin-31 by dermal conventional type 2 DCs, which, in turn, increases neuron sensitivity and provokes itching.

KW - dermal dendritic cells

KW - interleukin-31

KW - itch

KW - neuro-immune interaction

KW - transforming growth factor beta

KW - wound healing

UR - https://www.scopus.com/pages/publications/85089067162

U2 - 10.1016/j.immuni.2020.06.023

DO - 10.1016/j.immuni.2020.06.023

M3 - 文章

C2 - 32673566

AN - SCOPUS:85089067162

SN - 1074-7613

VL - 53

SP - 371-383.e5

JO - Immunity

JF - Immunity

IS - 2

ER -

The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching

摘要

联合国可持续发展目标

访问文件

其它文件与链接

学术指纹

引用此