The action of Shuganwan on experimental gastric ulcer

Objective: To study the action of Shuganwan (SHGW) on experimental gastric ulcer in mice. Methods: The anti-gastric ulcer action of SHGW was observed on the gastric ulcer induced by water immersion stress, reserpine and absolute ethyl alcohol. The effect on gastric secretion in rats was studied by pyloric ligation. The effect on gastrointestinal motility was observed by gastric emptying in mice. The analgesic effect was tested by the hot-plate test and writhing method. Results: SHGW markedly inhibited gastric ulcer induced by water immersion stress, reserpine and absolute ethyl alcohol. SHGW significantly inhibited the secretion of gastric acid and pepsin and promoted the secretion of gastric mucus. SHGW markedly delayed gastric emptying in normal mice and when gastric emptying was stimulated by neostigmine. SHGW mildly strengthend the effect of atropine on gastric emptying. SHGW enhanced hot pain threshold and decreased the number of twisting body in mice. Conclusion: Shuganwan may have anti-gastric ulcer action. The mechanism of the action might be associated with its inhibition of the secretion of gastric juice, promotion of the secretion of gastric mucus, inhibition of activity of gastric smooth muscle and analgetic effect.