Synthesizing 4′,4″(5″) di-tert-butyldibenzo 18-crown-6 monitored by online FTIR

Juan Fan; Chunhai Yi; Xiaorong Lan; Bolun Yang

doi:10.1002/jhet.1815

Synthesizing 4′,4″(5″) di-tert-butyldibenzo 18-crown-6 monitored by online FTIR

Juan Fan
, Chunhai Yi
, Xiaorong Lan
, Bolun Yang

化学工程与技术学院

Xi'an Jiaotong University

科研成果: 期刊稿件 › 文章 › 同行评审

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摘要

4′,4″(5″) Di-tert-butyldibenzo 18-crown-6 (DTBB18C6) was successfully synthesized by S_N2 nucleophilic substitution with 4-tert-butyl catechol as starting material. Effects of cyclization reagents, solvents, and templates were investigated. Reaction process was monitored by the real-time online FTIR to study the actual reaction route. The highest DTBB18C6 yield (above 33%) was obtained by using Cs₂CO₃ as the template, 2,2′-diethylene glycol ditosylate as the cyclization reagent, and THF as the solvent. From the result of FTIR, four different reaction stages of DTBB18C6 synthesis process were proposed.

源语言	英语
页（从-至）	1058-1062
页数	5
期刊	Journal of Heterocyclic Chemistry
卷	51
期	4
DOI	https://doi.org/10.1002/jhet.1815
出版状态	已出版 - 7月 2014

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@article{68a6665cff944005975f89d398df11b6,

title = "Synthesizing 4′,4″(5″) di-tert-butyldibenzo 18-crown-6 monitored by online FTIR",

abstract = "4′,4″(5″) Di-tert-butyldibenzo 18-crown-6 (DTBB18C6) was successfully synthesized by SN2 nucleophilic substitution with 4-tert-butyl catechol as starting material. Effects of cyclization reagents, solvents, and templates were investigated. Reaction process was monitored by the real-time online FTIR to study the actual reaction route. The highest DTBB18C6 yield (above 33\%) was obtained by using Cs2CO3 as the template, 2,2′-diethylene glycol ditosylate as the cyclization reagent, and THF as the solvent. From the result of FTIR, four different reaction stages of DTBB18C6 synthesis process were proposed.",

author = "Juan Fan and Chunhai Yi and Xiaorong Lan and Bolun Yang",

year = "2014",

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doi = "10.1002/jhet.1815",

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volume = "51",

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TY - JOUR

T1 - Synthesizing 4′,4″(5″) di-tert-butyldibenzo 18-crown-6 monitored by online FTIR

AU - Fan, Juan

AU - Yi, Chunhai

AU - Lan, Xiaorong

AU - Yang, Bolun

PY - 2014/7

Y1 - 2014/7

N2 - 4′,4″(5″) Di-tert-butyldibenzo 18-crown-6 (DTBB18C6) was successfully synthesized by SN2 nucleophilic substitution with 4-tert-butyl catechol as starting material. Effects of cyclization reagents, solvents, and templates were investigated. Reaction process was monitored by the real-time online FTIR to study the actual reaction route. The highest DTBB18C6 yield (above 33%) was obtained by using Cs2CO3 as the template, 2,2′-diethylene glycol ditosylate as the cyclization reagent, and THF as the solvent. From the result of FTIR, four different reaction stages of DTBB18C6 synthesis process were proposed.

AB - 4′,4″(5″) Di-tert-butyldibenzo 18-crown-6 (DTBB18C6) was successfully synthesized by SN2 nucleophilic substitution with 4-tert-butyl catechol as starting material. Effects of cyclization reagents, solvents, and templates were investigated. Reaction process was monitored by the real-time online FTIR to study the actual reaction route. The highest DTBB18C6 yield (above 33%) was obtained by using Cs2CO3 as the template, 2,2′-diethylene glycol ditosylate as the cyclization reagent, and THF as the solvent. From the result of FTIR, four different reaction stages of DTBB18C6 synthesis process were proposed.

UR - https://www.scopus.com/pages/publications/84905049521

U2 - 10.1002/jhet.1815

DO - 10.1002/jhet.1815

M3 - 文章

AN - SCOPUS:84905049521

SN - 0022-152X

VL - 51

SP - 1058

EP - 1062

JO - Journal of Heterocyclic Chemistry

JF - Journal of Heterocyclic Chemistry

IS - 4

ER -

Synthesizing 4′,4″(5″) di-tert-butyldibenzo 18-crown-6 monitored by online FTIR

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