Synthesis, DNA-binding and DNA-photocleavage properties of ruthenium(II) mixed-polypyridyl complex [Ru(tbz)2(dppz)]2+

Hui Jie Shi; Yu Chen; Feng Gao; Hui Juan Yu; Guan Ying Li; Hui Chao; Xian Fa Shi; Liang Nian Ji

doi:10.1016/j.molstruc.2008.06.021

Synthesis, DNA-binding and DNA-photocleavage properties of ruthenium(II) mixed-polypyridyl complex [Ru(tbz)₂(dppz)]²⁺

Hui Jie Shi
, Yu Chen
, Feng Gao
, Hui Juan Yu
, Guan Ying Li
, Hui Chao
, Xian Fa Shi
, Liang Nian Ji

科研成果: 期刊稿件 › 文章 › 同行评审

9 引用（Scopus）

摘要

A new ruthenium(II) complex [Ru(tbz)₂(dppz)]²⁺ (tbz = 2-(4′-thiazolyl)benzimidazole, dppz = dipyrido-[3,2-a:2′,3′-c]phenazine) has been synthesized and characterized by elemental analysis, electrospray mass spectra and ¹H NMR. The DNA-binding properties of the complex with calf thymus DNA was investigated by spectroscopic and viscosity measurements. The results suggest that the complex binds to DNA via an intercalative mode. Moreover, the complex has been found to promote the photocleavage of plasmid DNA pBR322 under irradiation at 365 nm. The mechanism studies reveal that singlet oxygen ¹O₂ plays a significant role in the photocleavage.

源语言	英语
页（从-至）	485-489
页数	5
期刊	Journal of Molecular Structure
卷	892
期	1-3
DOI	https://doi.org/10.1016/j.molstruc.2008.06.021
出版状态	已出版 - 15 12月 2008
已对外发布	是

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10.1016/j.molstruc.2008.06.021

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@article{66016009c24849078e59fba27fc0f12a,

title = "Synthesis, DNA-binding and DNA-photocleavage properties of ruthenium(II) mixed-polypyridyl complex [Ru(tbz)2(dppz)]2+",

abstract = "A new ruthenium(II) complex [Ru(tbz)2(dppz)]2+ (tbz = 2-(4′-thiazolyl)benzimidazole, dppz = dipyrido-[3,2-a:2′,3′-c]phenazine) has been synthesized and characterized by elemental analysis, electrospray mass spectra and 1H NMR. The DNA-binding properties of the complex with calf thymus DNA was investigated by spectroscopic and viscosity measurements. The results suggest that the complex binds to DNA via an intercalative mode. Moreover, the complex has been found to promote the photocleavage of plasmid DNA pBR322 under irradiation at 365 nm. The mechanism studies reveal that singlet oxygen 1O2 plays a significant role in the photocleavage.",

keywords = "DNA binding, Photocleavage, Polypyridine, Ru(II) complex, Synthesis, dppz",

author = "Shi, \{Hui Jie\} and Yu Chen and Feng Gao and Yu, \{Hui Juan\} and Li, \{Guan Ying\} and Hui Chao and Shi, \{Xian Fa\} and Ji, \{Liang Nian\}",

year = "2008",

month = dec,

day = "15",

doi = "10.1016/j.molstruc.2008.06.021",

language = "英语",

volume = "892",

pages = "485--489",

journal = "Journal of Molecular Structure",

issn = "0022-2860",

publisher = "Elsevier B.V.",

number = "1-3",

}

TY - JOUR

T1 - Synthesis, DNA-binding and DNA-photocleavage properties of ruthenium(II) mixed-polypyridyl complex [Ru(tbz)2(dppz)]2+

AU - Shi, Hui Jie

AU - Chen, Yu

AU - Gao, Feng

AU - Yu, Hui Juan

AU - Li, Guan Ying

AU - Chao, Hui

AU - Shi, Xian Fa

AU - Ji, Liang Nian

PY - 2008/12/15

Y1 - 2008/12/15

N2 - A new ruthenium(II) complex [Ru(tbz)2(dppz)]2+ (tbz = 2-(4′-thiazolyl)benzimidazole, dppz = dipyrido-[3,2-a:2′,3′-c]phenazine) has been synthesized and characterized by elemental analysis, electrospray mass spectra and 1H NMR. The DNA-binding properties of the complex with calf thymus DNA was investigated by spectroscopic and viscosity measurements. The results suggest that the complex binds to DNA via an intercalative mode. Moreover, the complex has been found to promote the photocleavage of plasmid DNA pBR322 under irradiation at 365 nm. The mechanism studies reveal that singlet oxygen 1O2 plays a significant role in the photocleavage.

AB - A new ruthenium(II) complex [Ru(tbz)2(dppz)]2+ (tbz = 2-(4′-thiazolyl)benzimidazole, dppz = dipyrido-[3,2-a:2′,3′-c]phenazine) has been synthesized and characterized by elemental analysis, electrospray mass spectra and 1H NMR. The DNA-binding properties of the complex with calf thymus DNA was investigated by spectroscopic and viscosity measurements. The results suggest that the complex binds to DNA via an intercalative mode. Moreover, the complex has been found to promote the photocleavage of plasmid DNA pBR322 under irradiation at 365 nm. The mechanism studies reveal that singlet oxygen 1O2 plays a significant role in the photocleavage.

KW - DNA binding

KW - Photocleavage

KW - Polypyridine

KW - Ru(II) complex

KW - Synthesis

KW - dppz

UR - https://www.scopus.com/pages/publications/55749107104

U2 - 10.1016/j.molstruc.2008.06.021

DO - 10.1016/j.molstruc.2008.06.021

M3 - 文章

AN - SCOPUS:55749107104

SN - 0022-2860

VL - 892

SP - 485

EP - 489

JO - Journal of Molecular Structure

JF - Journal of Molecular Structure

IS - 1-3

ER -

Synthesis, DNA-binding and DNA-photocleavage properties of ruthenium(II) mixed-polypyridyl complex [Ru(tbz)2(dppz)]2+

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Synthesis, DNA-binding and DNA-photocleavage properties of ruthenium(II) mixed-polypyridyl complex [Ru(tbz)₂(dppz)]²⁺