TY - JOUR
T1 - Study on the Anticancer Effects of Plasma-Activated Saline Perfusion Based on a Microfluidic System
AU - Zhang, Jishen
AU - Xu, Shengduo
AU - Jing, Xixi
AU - Liu, Dingxin
AU - Zhang, Hao
AU - Wang, Zifeng
AU - Xu, Dehui
AU - Zhang, Geng
AU - Yang, Xiaojian
AU - Wang, Xiaohua
AU - Kong, Michael G.
AU - Rong, Mingzhe
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2023/1
Y1 - 2023/1
N2 - As a means of applying cold atmospheric plasma (CAP), plasma-activated solutions have received extensive attention for their excellent anticancer effects. However, previous studies have focused mainly on the local injection of plasma-activated solutions for cancer treatment while ignoring the anticancer effects of intraluminal plasma-activated solution perfusion. In this paper, the anticancer effects of flowing plasma-activated saline (PAS) on human bladder cancer cell lines (J82) were studied in vitro in a microfluidic system. It is noteworthy that flowing PAS can kill cancer cells more efficiently than PAS immersion. Further experimental results show that the anticancer effects of PAS on J82 cells in the microcavity are affected by plasma irradiation time, perfusion time and liquid flow rate. Our research suggests that PAS perfusion therapy can become a controllable alternative therapy pathway in the future clinical treatment of intracavitary tumors.
AB - As a means of applying cold atmospheric plasma (CAP), plasma-activated solutions have received extensive attention for their excellent anticancer effects. However, previous studies have focused mainly on the local injection of plasma-activated solutions for cancer treatment while ignoring the anticancer effects of intraluminal plasma-activated solution perfusion. In this paper, the anticancer effects of flowing plasma-activated saline (PAS) on human bladder cancer cell lines (J82) were studied in vitro in a microfluidic system. It is noteworthy that flowing PAS can kill cancer cells more efficiently than PAS immersion. Further experimental results show that the anticancer effects of PAS on J82 cells in the microcavity are affected by plasma irradiation time, perfusion time and liquid flow rate. Our research suggests that PAS perfusion therapy can become a controllable alternative therapy pathway in the future clinical treatment of intracavitary tumors.
KW - Cold atmospheric plasma
KW - Microfluidic system
KW - Perfusion therapy
KW - Plasma-activated saline
KW - Reactive oxygen species
UR - https://www.scopus.com/pages/publications/85141989615
U2 - 10.1007/s11090-022-10297-5
DO - 10.1007/s11090-022-10297-5
M3 - 文章
AN - SCOPUS:85141989615
SN - 0272-4324
VL - 43
SP - 99
EP - 110
JO - Plasma Chemistry and Plasma Processing
JF - Plasma Chemistry and Plasma Processing
IS - 1
ER -
可持续发展目标 3 良好健康与福祉