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Study of non-viral gene transfer of NB4 cells

科研成果: 书/报告/会议事项章节会议稿件同行评审

摘要

Post-Transcriptional Gene Silencing and RNA interference (RNAi) are terms describing the specific suppression of genes by complementary dsRNA. High-efficiency transfection is an essential first step for achieving effective gene knockdown. Non-viral transfection include chemical-transfection and electrotransfection. For a particular cell line, select the appropriate transfection method is very important. In this study, we compared a variety of commercially available reagents and electrotransfection, approaches to define methods for efficient delivery of siRNA to NB4 cells. Fluorescently-labelled siRNA were tested. We report that different methods have different effects. The results provide guidelines for optimal siRNA-mediated knockdown in the NB4 cells.

源语言英语
主期刊名Material and Manufacturing Technology II
333-337
页数5
DOI
出版状态已出版 - 2012
已对外发布
活动2011 2nd International Conference on Material and Manufacturing Technology, ICMMT 2011 - Xiamen, 中国
期限: 8 7月 201111 7月 2011

出版系列

姓名Advanced Materials Research
341-342
ISSN(印刷版)1022-6680

会议

会议2011 2nd International Conference on Material and Manufacturing Technology, ICMMT 2011
国家/地区中国
Xiamen
时期8/07/1111/07/11

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