Strategies for targeting the DNA damage respones for cancer therapeutics

Dan Zhang; Hai Bo Wang; Kathryn L. Brinkman; Su Xia Han; Bo Xu

doi:10.5732/cjc.012.10087

Strategies for targeting the DNA damage respones for cancer therapeutics

Dan Zhang
, Hai Bo Wang
, Kathryn L. Brinkman
, Su Xia Han
, Bo Xu

科研成果: 期刊稿件 › 社论

6 引用（Scopus）

摘要

The DNA damage response is critical for cells to maintain genome stability and survival. In this review, we discuss approaches to targeting critical elements of the DNA damage response for radiosensitization and chemosensitization. In addition, we also discuss strategies for targeting DNA damage response and DNA repair defects in cancer cells for synthetic lethality.

源语言	英语
页（从-至）	359-363
页数	5
期刊	Ai zheng = Aizheng = Chinese journal of cancer
卷	31
期	8
DOI	https://doi.org/10.5732/cjc.012.10087
出版状态	已出版 - 14 6月 2012
已对外发布	是

联合国可持续发展目标

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可持续发展目标 3 良好健康与福祉

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10.5732/cjc.012.10087

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title = "Strategies for targeting the DNA damage respones for cancer therapeutics",

abstract = "The DNA damage response is critical for cells to maintain genome stability and survival. In this review, we discuss approaches to targeting critical elements of the DNA damage response for radiosensitization and chemosensitization. In addition, we also discuss strategies for targeting DNA damage response and DNA repair defects in cancer cells for synthetic lethality.",

keywords = "DNA damage response, DNA repair, PARP inhibitors, Synthetic lethality",

author = "Dan Zhang and Wang, \{Hai Bo\} and Brinkman, \{Kathryn L.\} and Han, \{Su Xia\} and Bo Xu",

year = "2012",

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day = "14",

doi = "10.5732/cjc.012.10087",

language = "英语",

volume = "31",

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number = "8",

}

TY - JOUR

T1 - Strategies for targeting the DNA damage respones for cancer therapeutics

AU - Zhang, Dan

AU - Wang, Hai Bo

AU - Brinkman, Kathryn L.

AU - Han, Su Xia

AU - Xu, Bo

PY - 2012/6/14

Y1 - 2012/6/14

N2 - The DNA damage response is critical for cells to maintain genome stability and survival. In this review, we discuss approaches to targeting critical elements of the DNA damage response for radiosensitization and chemosensitization. In addition, we also discuss strategies for targeting DNA damage response and DNA repair defects in cancer cells for synthetic lethality.

AB - The DNA damage response is critical for cells to maintain genome stability and survival. In this review, we discuss approaches to targeting critical elements of the DNA damage response for radiosensitization and chemosensitization. In addition, we also discuss strategies for targeting DNA damage response and DNA repair defects in cancer cells for synthetic lethality.

KW - DNA damage response

KW - DNA repair

KW - PARP inhibitors

KW - Synthetic lethality

UR - https://www.scopus.com/pages/publications/84865018549

U2 - 10.5732/cjc.012.10087

DO - 10.5732/cjc.012.10087

M3 - 社论

C2 - 22704491

AN - SCOPUS:84865018549

SN - 1000-467X

VL - 31

SP - 359

EP - 363

JO - Ai zheng = Aizheng = Chinese journal of cancer

JF - Ai zheng = Aizheng = Chinese journal of cancer

IS - 8

ER -

Strategies for targeting the DNA damage respones for cancer therapeutics

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