TY - JOUR
T1 - Star-Shaped, Biodegradable, and Elastomeric PLLA-PEG-POSS Hybrid Membrane with Biomineralization Activity for Guiding Bone Tissue Regeneration
AU - Xie, Meihua
AU - Ge, Juan
AU - Lei, Bo
AU - Zhang, Qian
AU - Chen, Xiaofeng
AU - Ma, Peter X.
N1 - Publisher Copyright:
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Multi-armed biodegradable polymers have attracted much attention in biomedical applications, due to their special structure and properties. However, multi-armed organic-inorganic hybrids with high mechanical properties and biomineralization activity have not been reported yet. Here, star-shaped poly-L-lactide-poly (ethylene glycol)-polyhedral oligomeric silsesquioxane (SPPS) hybrid membranes are fabricated for the first time for guiding bone regeneration applications by a photo-crosslinking method using inositol as a core. SPPS demonstrates tunable mechanical properties (5.8 ± 0.2μ130 ± 23 MPa in tensile modulus, 30 ± 6%μ144 ± 13% in elongation, beyond 90% recovery), biodegradation, biomineralization activity and good osteoblast biocompatibility. These results suggest that our hybrids membrane may have promising applications in guiding bone regeneration.
AB - Multi-armed biodegradable polymers have attracted much attention in biomedical applications, due to their special structure and properties. However, multi-armed organic-inorganic hybrids with high mechanical properties and biomineralization activity have not been reported yet. Here, star-shaped poly-L-lactide-poly (ethylene glycol)-polyhedral oligomeric silsesquioxane (SPPS) hybrid membranes are fabricated for the first time for guiding bone regeneration applications by a photo-crosslinking method using inositol as a core. SPPS demonstrates tunable mechanical properties (5.8 ± 0.2μ130 ± 23 MPa in tensile modulus, 30 ± 6%μ144 ± 13% in elongation, beyond 90% recovery), biodegradation, biomineralization activity and good osteoblast biocompatibility. These results suggest that our hybrids membrane may have promising applications in guiding bone regeneration.
KW - biomineralization
KW - bone tissue regeneration
KW - hybrid structures
KW - mechanical properties
KW - silica-based biomaterials
UR - https://www.scopus.com/pages/publications/84955186542
U2 - 10.1002/mabi.201500237
DO - 10.1002/mabi.201500237
M3 - 文章
C2 - 26241149
AN - SCOPUS:84955186542
SN - 1616-5187
VL - 15
SP - 1656
EP - 1662
JO - Macromolecular Bioscience
JF - Macromolecular Bioscience
IS - 12
ER -