TY - JOUR
T1 - Star Poly(β-amino esters) Obtained from the Combination of Linear Poly(β-amino esters) and Polyethylenimine
AU - Huang, Xiaobei
AU - Zhou, Dezhong
AU - Zeng, Ming
AU - Alshehri, Fatma
AU - Li, Xiaolin
AU - O'Keeffe-Ahern, Jonathan
AU - Gao, Yongsheng
AU - Pierucci, Luca
AU - Greiser, Udo
AU - Yin, Guangfu
AU - Wang, Wenxin
N1 - Publisher Copyright:
© 2017 American Chemical Society.
PY - 2017/6/20
Y1 - 2017/6/20
N2 - Composed of a three-dimensional structure with a central core and multiple radiating linear "arms", star polymers represent a significant type of branched macromolecular architectures. Due to the spatially defined core-shell-periphery architecture, star polymers have demonstrated their superiority in a variety of biomedical applications such as drug/gene delivery, molecular imaging, antibacterial agents, and so on. In this paper, we report the successful synthesis of a new type of star-shape poly(β-amino esters) with low molecular weight PEI as core and linear PAE (LPAE) as arms. This new star-PAE exhibits low cytotoxicity and high gene transfection efficacy. Star-PAE achieved between 264-fold and 14781-fold higher gene transfection efficiency of primary rat adipose derived mesenchymal stem cells in comparison with studies performed with the individual PEI and LPAE, respectively. The results suggest that star-PAE is a promising nonviral gene delivery vector.
AB - Composed of a three-dimensional structure with a central core and multiple radiating linear "arms", star polymers represent a significant type of branched macromolecular architectures. Due to the spatially defined core-shell-periphery architecture, star polymers have demonstrated their superiority in a variety of biomedical applications such as drug/gene delivery, molecular imaging, antibacterial agents, and so on. In this paper, we report the successful synthesis of a new type of star-shape poly(β-amino esters) with low molecular weight PEI as core and linear PAE (LPAE) as arms. This new star-PAE exhibits low cytotoxicity and high gene transfection efficacy. Star-PAE achieved between 264-fold and 14781-fold higher gene transfection efficiency of primary rat adipose derived mesenchymal stem cells in comparison with studies performed with the individual PEI and LPAE, respectively. The results suggest that star-PAE is a promising nonviral gene delivery vector.
UR - https://www.scopus.com/pages/publications/85021131605
U2 - 10.1021/acsmacrolett.7b00319
DO - 10.1021/acsmacrolett.7b00319
M3 - 文章
C2 - 35650840
AN - SCOPUS:85021131605
SN - 2161-1653
VL - 6
SP - 575
EP - 579
JO - ACS Macro Letters
JF - ACS Macro Letters
IS - 6
ER -