Spatially resolved single-cell atlas reveals the macroevolutionary trajectory of animal hearts

Shanshan Lian; Wei Wang; Yaoxin Liu; Meina Lu; Wentao Han; Jiaxin Luo; Xuejiao Zhang; Yue Pang; Yuru Li; Yufeng Li; Xin Dang; Peiyan Wang; Yating Qin; Ning Tan; Fang Zhang; Jin Zhang; Shuai Gao; Runyi Zhang; Lidong Guo; Lei Jiang; Pengchong Zhang; Yuehuan Zhang; Zhe Qu; Shanshan Pan; Yue Zhang; Naina Hu; Yadong Chen; Yun Cao; Wenbin Li; Xiaomei Chen; Junjie Shi; Shuaiqi Yang; Yiran Li; Qiuyun Song; Lisui Bao; Yuli Li; Xiawei Liu; Jing Wang; Lingling Zhang; Rui Li; Xin Yu; Tao Yang; Jing Chen; Ling Li; Mengqi Zhang; Lei Li; Ruihua Zhang; Hongyan Li; Ying Gu; Xun Xu; Huanming Yang; Zhenmin Bao; C. Geoffrey Burns; Caroline E. Burns; Robert G. Kelly; Jianxun Wang; Yang Zhao; Ying Su; Guangyi Fan; Qun Liu; Shi Wang; Ji Feng Fei; Silin Pan; Long Zhao

doi:10.1126/science.adw0855

Spatially resolved single-cell atlas reveals the macroevolutionary trajectory of animal hearts

Shanshan Lian
, Wei Wang
, Yaoxin Liu
, Meina Lu
, Wentao Han
, Jiaxin Luo
, Xuejiao Zhang
, Yue Pang
, Yuru Li
, Yufeng Li
, Xin Dang
, Peiyan Wang
, Yating Qin
, Ning Tan
, Fang Zhang
, Jin Zhang
, Shuai Gao
, Runyi Zhang
, Lidong Guo
, Lei Jiang

Pengchong Zhang, Yuehuan Zhang, Zhe Qu, Shanshan Pan, Yue Zhang, Naina Hu, Yadong Chen, Yun Cao, Wenbin Li, Xiaomei Chen, Junjie Shi, Shuaiqi Yang, Yiran Li, Qiuyun Song, Lisui Bao, Yuli Li, Xiawei Liu, Jing Wang, Lingling Zhang, Rui Li, Xin Yu, Tao Yang, Jing Chen, Ling Li, Mengqi Zhang, Lei Li, Ruihua Zhang, Hongyan Li, Ying Gu, Xun Xu, Huanming Yang, Zhenmin Bao, C. Geoffrey Burns, Caroline E. Burns, Robert G. Kelly, Jianxun Wang, Yang Zhao, Ying Su, Guangyi Fan, Qun Liu, Shi Wang, Ji Feng Fei, Silin Pan, Long Zhao

Fang Zongxi Center for Marine Evo-Devo and MOE Key Laboratory of Marine Genetics and Breeding
Ocean University of China
Guangdong Academy of Medical Sciences
Key Laboratory of Evolution and Marine Biodiversity (Ministry of Education)
College of Life Science
Liaoning Normal University
Laboratory for Marine Biology and Biotechnology
Marine Science and Technology Center
State Key Laboratory of Natural and Biomimetic Drugs
Peking University
School of Basic Medicine
Qingdao University
BGI Research
Department of Biology
University of Copenhagen
Department of Cardiology
College of Fisheries
CAS - South China Sea Institute of Oceanology
China National GeneBank
BGl Research
MGI Tech Co., Ltd.
BGI Research
University of Chinese Academy of Sciences
Chinese Academy of Sciences
Zhejiang University
Southern Marine Science and Engineering Guangdong Laboratory
Qingdao Institute of Blue Seed Industry
Division of Basic and Translational Cardiovascular Research
Harvard University
CNRS UMR 7288
Aix Marseille Université
BGI-Shenzhen
Department of Pathology
The Innovation Centre of Ministry of Education for Development and Diseases
South China University of Technology
BGI Research

科研成果: 期刊稿件 › 文章 › 同行评审

摘要

Animal hearts display diverse anatomical structures during adaptive evolution. Here, we present a multiomics atlas of adult hearts from 27 species across chordates, arthropods, and mollusks. Joint analysis indicates that bilateria hearts share a core gene repertoire, taking a stepwise “add-on” approach as a universal evolutionary strategy. the “proto-heart” is populated by key cell types, including cardiomyocytes, fibroblasts, endothelial cells, and neural cells, which maintained core signatures while evolving with shifts in living environments and corresponding adaptations in the cardiovascular system. Additionally, we reveal an evolutionarily conserved cardiomyocyte state dynamic potentially linked to cardiac development and stress responses. Finally, we identify a common molecular program underpinning chamber evolution from a ventricular foundation. this work establishes a resource for understanding the intrinsic mechanisms of heart evolution.

源语言	英语
期刊论文编号	eadw0855
期刊	Science
卷	393
期	6815
DOI	https://doi.org/10.1126/science.adw0855
出版状态	已出版 - 3 9月 2026
已对外发布	是

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Lian, S., Wang, W., Liu, Y., Lu, M., Han, W., Luo, J., Zhang, X., Pang, Y., Li, Y., Li, Y., Dang, X., Wang, P., Qin, Y., Tan, N., Zhang, F., Zhang, J., Gao, S., Zhang, R., Guo, L., ... Zhao, L. (2026). Spatially resolved single-cell atlas reveals the macroevolutionary trajectory of animal hearts. Science, 393(6815), 期刊论文 eadw0855. https://doi.org/10.1126/science.adw0855

@article{053f2d01d9d04331b5dcd9540393c760,

title = "Spatially resolved single-cell atlas reveals the macroevolutionary trajectory of animal hearts",

abstract = "Animal hearts display diverse anatomical structures during adaptive evolution. Here, we present a multiomics atlas of adult hearts from 27 species across chordates, arthropods, and mollusks. Joint analysis indicates that bilateria hearts share a core gene repertoire, taking a stepwise {\textquotedblleft}add-on{\textquotedblright} approach as a universal evolutionary strategy. the {\textquotedblleft}proto-heart{\textquotedblright} is populated by key cell types, including cardiomyocytes, fibroblasts, endothelial cells, and neural cells, which maintained core signatures while evolving with shifts in living environments and corresponding adaptations in the cardiovascular system. Additionally, we reveal an evolutionarily conserved cardiomyocyte state dynamic potentially linked to cardiac development and stress responses. Finally, we identify a common molecular program underpinning chamber evolution from a ventricular foundation. this work establishes a resource for understanding the intrinsic mechanisms of heart evolution.",

author = "Shanshan Lian and Wei Wang and Yaoxin Liu and Meina Lu and Wentao Han and Jiaxin Luo and Xuejiao Zhang and Yue Pang and Yuru Li and Yufeng Li and Xin Dang and Peiyan Wang and Yating Qin and Ning Tan and Fang Zhang and Jin Zhang and Shuai Gao and Runyi Zhang and Lidong Guo and Lei Jiang and Pengchong Zhang and Yuehuan Zhang and Zhe Qu and Shanshan Pan and Yue Zhang and Naina Hu and Yadong Chen and Yun Cao and Wenbin Li and Xiaomei Chen and Junjie Shi and Shuaiqi Yang and Yiran Li and Qiuyun Song and Lisui Bao and Yuli Li and Xiawei Liu and Jing Wang and Lingling Zhang and Rui Li and Xin Yu and Tao Yang and Jing Chen and Ling Li and Mengqi Zhang and Lei Li and Ruihua Zhang and Hongyan Li and Ying Gu and Xun Xu and Huanming Yang and Zhenmin Bao and Burns, \{C. Geoffrey\} and Burns, \{Caroline E.\} and Kelly, \{Robert G.\} and Jianxun Wang and Yang Zhao and Ying Su and Guangyi Fan and Qun Liu and Shi Wang and Fei, \{Ji Feng\} and Silin Pan and Long Zhao",

note = "Publisher Copyright: {\textcopyright} 2026 The Authors, some rights reserved;",

year = "2026",

month = sep,

day = "3",

doi = "10.1126/science.adw0855",

language = "英语",

volume = "393",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6815",

}

Lian, S, Wang, W, Liu, Y, Lu, M, Han, W, Luo, J, Zhang, X, Pang, Y, Li, Y, Li, Y, Dang, X, Wang, P, Qin, Y, Tan, N, Zhang, F, Zhang, J, Gao, S, Zhang, R, Guo, L, Jiang, L, Zhang, P, Zhang, Y, Qu, Z, Pan, S, Zhang, Y, Hu, N, Chen, Y, Cao, Y, Li, W, Chen, X, Shi, J, Yang, S, Li, Y, Song, Q, Bao, L, Li, Y, Liu, X, Wang, J, Zhang, L, Li, R, Yu, X, Yang, T, Chen, J, Li, L, Zhang, M, Li, L, Zhang, R, Li, H, Gu, Y, Xu, X, Yang, H, Bao, Z, Burns, CG, Burns, CE, Kelly, RG, Wang, J, Zhao, Y, Su, Y, Fan, G, Liu, Q, Wang, S, Fei, JF, Pan, S & Zhao, L 2026, 'Spatially resolved single-cell atlas reveals the macroevolutionary trajectory of animal hearts', Science, 卷 393, 号码 6815, eadw0855. https://doi.org/10.1126/science.adw0855

TY - JOUR

T1 - Spatially resolved single-cell atlas reveals the macroevolutionary trajectory of animal hearts

AU - Lian, Shanshan

AU - Wang, Wei

AU - Liu, Yaoxin

AU - Lu, Meina

AU - Han, Wentao

AU - Luo, Jiaxin

AU - Zhang, Xuejiao

AU - Pang, Yue

AU - Li, Yuru

AU - Li, Yufeng

AU - Dang, Xin

AU - Wang, Peiyan

AU - Qin, Yating

AU - Tan, Ning

AU - Zhang, Fang

AU - Zhang, Jin

AU - Gao, Shuai

AU - Zhang, Runyi

AU - Guo, Lidong

AU - Jiang, Lei

AU - Zhang, Pengchong

AU - Zhang, Yuehuan

AU - Qu, Zhe

AU - Pan, Shanshan

AU - Zhang, Yue

AU - Hu, Naina

AU - Chen, Yadong

AU - Cao, Yun

AU - Li, Wenbin

AU - Chen, Xiaomei

AU - Shi, Junjie

AU - Yang, Shuaiqi

AU - Li, Yiran

AU - Song, Qiuyun

AU - Bao, Lisui

AU - Li, Yuli

AU - Liu, Xiawei

AU - Wang, Jing

AU - Zhang, Lingling

AU - Li, Rui

AU - Yu, Xin

AU - Yang, Tao

AU - Chen, Jing

AU - Li, Ling

AU - Zhang, Mengqi

AU - Li, Lei

AU - Zhang, Ruihua

AU - Li, Hongyan

AU - Gu, Ying

AU - Xu, Xun

AU - Yang, Huanming

AU - Bao, Zhenmin

AU - Burns, C. Geoffrey

AU - Burns, Caroline E.

AU - Kelly, Robert G.

AU - Wang, Jianxun

AU - Zhao, Yang

AU - Su, Ying

AU - Fan, Guangyi

AU - Liu, Qun

AU - Wang, Shi

AU - Fei, Ji Feng

AU - Pan, Silin

AU - Zhao, Long

PY - 2026/9/3

Y1 - 2026/9/3

N2 - Animal hearts display diverse anatomical structures during adaptive evolution. Here, we present a multiomics atlas of adult hearts from 27 species across chordates, arthropods, and mollusks. Joint analysis indicates that bilateria hearts share a core gene repertoire, taking a stepwise “add-on” approach as a universal evolutionary strategy. the “proto-heart” is populated by key cell types, including cardiomyocytes, fibroblasts, endothelial cells, and neural cells, which maintained core signatures while evolving with shifts in living environments and corresponding adaptations in the cardiovascular system. Additionally, we reveal an evolutionarily conserved cardiomyocyte state dynamic potentially linked to cardiac development and stress responses. Finally, we identify a common molecular program underpinning chamber evolution from a ventricular foundation. this work establishes a resource for understanding the intrinsic mechanisms of heart evolution.

AB - Animal hearts display diverse anatomical structures during adaptive evolution. Here, we present a multiomics atlas of adult hearts from 27 species across chordates, arthropods, and mollusks. Joint analysis indicates that bilateria hearts share a core gene repertoire, taking a stepwise “add-on” approach as a universal evolutionary strategy. the “proto-heart” is populated by key cell types, including cardiomyocytes, fibroblasts, endothelial cells, and neural cells, which maintained core signatures while evolving with shifts in living environments and corresponding adaptations in the cardiovascular system. Additionally, we reveal an evolutionarily conserved cardiomyocyte state dynamic potentially linked to cardiac development and stress responses. Finally, we identify a common molecular program underpinning chamber evolution from a ventricular foundation. this work establishes a resource for understanding the intrinsic mechanisms of heart evolution.

UR - https://www.scopus.com/pages/publications/105049283725

U2 - 10.1126/science.adw0855

DO - 10.1126/science.adw0855

M3 - 文章

C2 - 42490418

AN - SCOPUS:105049283725

SN - 0036-8075

VL - 393

JO - Science

JF - Science

IS - 6815

M1 - eadw0855

ER -

Spatially resolved single-cell atlas reveals the macroevolutionary trajectory of animal hearts

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