Solubility of naringin in ethanol and water mixtures from 283.15 to 318.15 K

The solubility of naringin in the binary system of ethanol and water was measured by using UV spectrophotometric method at the maximum absorption wavelength (UV = 283 nm) from 283.15 K to 318.15 K under atmospheric pressure. The solubility increases with the increasing temperature and in the solvent system it exhibits a synergistic effect. The modified Apelblat model was applied to correlate the experimental solubility data, and the calculated solubilities were in good agreement with the experimental results. The process of the dissolution of naringin was always endothermic, and was influenced by two mechanisms which are enthalpy-driven and entropy-driven. Non-linear enthalpy-entropy compensation was found for naringin in the binary system of ethanol and water.