Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma

Yunfan Sun; Liang Wu; Yu Zhong; Kaiqian Zhou; Yong Hou; Zifei Wang; Zefan Zhang; Jiarui Xie; Chunqing Wang; Dandan Chen; Yaling Huang; Xiaochan Wei; Yinghong Shi; Zhikun Zhao; Yuehua Li; Ziwei Guo; Qichao Yu; Liqin Xu; Giacomo Volpe; Shuangjian Qiu; Jian Zhou; Carl Ward; Huichuan Sun; Ye Yin; Xun Xu; Xiangdong Wang; Miguel A. Esteban; Huanming Yang; Jian Wang; Michael Dean; Yaguang Zhang; Shiping Liu; Xinrong Yang; Jia Fan

doi:10.1016/j.cell.2020.11.041

Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma

Yunfan Sun
, Liang Wu
, Yu Zhong
, Kaiqian Zhou
, Yong Hou
, Zifei Wang
, Zefan Zhang
, Jiarui Xie
, Chunqing Wang
, Dandan Chen
, Yaling Huang
, Xiaochan Wei
, Yinghong Shi
, Zhikun Zhao
, Yuehua Li
, Ziwei Guo
, Qichao Yu
, Liqin Xu
, Giacomo Volpe
, Shuangjian Qiu

Jian Zhou, Carl Ward, Huichuan Sun, Ye Yin, Xun Xu, Xiangdong Wang, Miguel A. Esteban, Huanming Yang, Jian Wang, Michael Dean, Yaguang Zhang, Shiping Liu, Xinrong Yang, Jia Fan

Fudan University
BGI-Shenzhen
University of Chinese Academy of Sciences
South China University of Technology
CAS - Guangzhou Institute of Biomedicine and Health
Guangdong Provincial Key Laboratory of Genome Read and Write
Chinese Academy of Sciences
Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)
Zhejiang University
National Institutes of Health
CAS - Center for Excellence in Molecular Cell Science

科研成果: 期刊稿件 › 文章 › 同行评审

731 引用（Scopus）

摘要

Single-cell analysis of primary and relapsed hepatocellular carcinoma tumors from patients reveal innate-like CD8⁺ T cells with low cytotoxicity and clonal expansion in the latter that may explain the compromised antitumor immunity and poor prognosis associated with liver cancer.

源语言	英语
页（从-至）	404-421.e16
期刊	Cell
卷	184
期	2
DOI	https://doi.org/10.1016/j.cell.2020.11.041
出版状态	已出版 - 21 1月 2021
已对外发布	是

联合国可持续发展目标

此成果有助于实现下列可持续发展目标：

可持续发展目标 3 良好健康与福祉

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10.1016/j.cell.2020.11.041

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@article{5c12db949a274f849ec62d4b1f35e4c3,

title = "Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma",

abstract = "Single-cell analysis of primary and relapsed hepatocellular carcinoma tumors from patients reveal innate-like CD8+ T cells with low cytotoxicity and clonal expansion in the latter that may explain the compromised antitumor immunity and poor prognosis associated with liver cancer.",

keywords = "early-relapse tumor, hepatocellular carcinoma, immune microenvironment, immune therapy, single-cell RNA sequencing, tumor ecosystem",

author = "Yunfan Sun and Liang Wu and Yu Zhong and Kaiqian Zhou and Yong Hou and Zifei Wang and Zefan Zhang and Jiarui Xie and Chunqing Wang and Dandan Chen and Yaling Huang and Xiaochan Wei and Yinghong Shi and Zhikun Zhao and Yuehua Li and Ziwei Guo and Qichao Yu and Liqin Xu and Giacomo Volpe and Shuangjian Qiu and Jian Zhou and Carl Ward and Huichuan Sun and Ye Yin and Xun Xu and Xiangdong Wang and Esteban, \{Miguel A.\} and Huanming Yang and Jian Wang and Michael Dean and Yaguang Zhang and Shiping Liu and Xinrong Yang and Jia Fan",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2021",

month = jan,

day = "21",

doi = "10.1016/j.cell.2020.11.041",

language = "英语",

volume = "184",

pages = "404--421.e16",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier B.V.",

number = "2",

}

Sun, Y, Wu, L, Zhong, Y, Zhou, K, Hou, Y, Wang, Z, Zhang, Z, Xie, J, Wang, C, Chen, D, Huang, Y, Wei, X, Shi, Y, Zhao, Z, Li, Y, Guo, Z, Yu, Q, Xu, L, Volpe, G, Qiu, S, Zhou, J, Ward, C, Sun, H, Yin, Y, Xu, X, Wang, X, Esteban, MA, Yang, H, Wang, J, Dean, M, Zhang, Y, Liu, S, Yang, X & Fan, J 2021, 'Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma', Cell, 卷 184, 号码 2, 页码 404-421.e16. https://doi.org/10.1016/j.cell.2020.11.041

TY - JOUR

T1 - Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma

AU - Sun, Yunfan

AU - Wu, Liang

AU - Zhong, Yu

AU - Zhou, Kaiqian

AU - Hou, Yong

AU - Wang, Zifei

AU - Zhang, Zefan

AU - Xie, Jiarui

AU - Wang, Chunqing

AU - Chen, Dandan

AU - Huang, Yaling

AU - Wei, Xiaochan

AU - Shi, Yinghong

AU - Zhao, Zhikun

AU - Li, Yuehua

AU - Guo, Ziwei

AU - Yu, Qichao

AU - Xu, Liqin

AU - Volpe, Giacomo

AU - Qiu, Shuangjian

AU - Zhou, Jian

AU - Ward, Carl

AU - Sun, Huichuan

AU - Yin, Ye

AU - Xu, Xun

AU - Wang, Xiangdong

AU - Esteban, Miguel A.

AU - Yang, Huanming

AU - Wang, Jian

AU - Dean, Michael

AU - Zhang, Yaguang

AU - Liu, Shiping

AU - Yang, Xinrong

AU - Fan, Jia

PY - 2021/1/21

Y1 - 2021/1/21

N2 - Single-cell analysis of primary and relapsed hepatocellular carcinoma tumors from patients reveal innate-like CD8+ T cells with low cytotoxicity and clonal expansion in the latter that may explain the compromised antitumor immunity and poor prognosis associated with liver cancer.

AB - Single-cell analysis of primary and relapsed hepatocellular carcinoma tumors from patients reveal innate-like CD8+ T cells with low cytotoxicity and clonal expansion in the latter that may explain the compromised antitumor immunity and poor prognosis associated with liver cancer.

KW - early-relapse tumor

KW - hepatocellular carcinoma

KW - immune microenvironment

KW - immune therapy

KW - single-cell RNA sequencing

KW - tumor ecosystem

UR - https://www.scopus.com/pages/publications/85099162147

U2 - 10.1016/j.cell.2020.11.041

DO - 10.1016/j.cell.2020.11.041

M3 - 文章

C2 - 33357445

AN - SCOPUS:85099162147

SN - 0092-8674

VL - 184

SP - 404-421.e16

JO - Cell

JF - Cell

IS - 2

ER -

Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma

摘要

联合国可持续发展目标

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