Simulation Study on Improving the Performance of Lateral Flow Assays by Adding Hydrophobic Barriers

Ling Xiao Li; Xiao Cong He; Zhi Liu; Zhi Guo Qu; Feng Xu

Simulation Study on Improving the Performance of Lateral Flow Assays by Adding Hydrophobic Barriers

Ling Xiao Li
, Xiao Cong He
, Zhi Liu
, Zhi Guo Qu
, Feng Xu

Xi'an Jiaotong University

科研成果: 期刊稿件 › 文章 › 同行评审

摘要

Based on the Brinkman equation and the chemical reaction equation, a 3D fluid-reaction coupling numerical model is built to study the effects of material properties of different components of the lateral flow assays (LFAs) on the flow. The velocity and concentration fields of LFAs are analyzed after adding PDMS hydrophobic barrier in the NC membrane. The modified lateral flow assays can obtain improved performance. The results can provide theoretical guidance for the design of the lateral flow assays.

源语言	英语
页（从-至）	1524-1528
页数	5
期刊	Kung Cheng Je Wu Li Hsueh Pao/Journal of Engineering Thermophysics
卷	41
期	6
出版状态	已出版 - 1 6月 2020

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title = "Simulation Study on Improving the Performance of Lateral Flow Assays by Adding Hydrophobic Barriers",

abstract = "Based on the Brinkman equation and the chemical reaction equation, a 3D fluid-reaction coupling numerical model is built to study the effects of material properties of different components of the lateral flow assays (LFAs) on the flow. The velocity and concentration fields of LFAs are analyzed after adding PDMS hydrophobic barrier in the NC membrane. The modified lateral flow assays can obtain improved performance. The results can provide theoretical guidance for the design of the lateral flow assays.",

keywords = "Convection-diffusion-reaction model, Lateral flow assays, PDMS hydrophobic barrier",

author = "Li, \{Ling Xiao\} and He, \{Xiao Cong\} and Zhi Liu and Qu, \{Zhi Guo\} and Feng Xu",

year = "2020",

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T1 - Simulation Study on Improving the Performance of Lateral Flow Assays by Adding Hydrophobic Barriers

AU - Li, Ling Xiao

AU - He, Xiao Cong

AU - Liu, Zhi

AU - Qu, Zhi Guo

AU - Xu, Feng

PY - 2020/6/1

Y1 - 2020/6/1

N2 - Based on the Brinkman equation and the chemical reaction equation, a 3D fluid-reaction coupling numerical model is built to study the effects of material properties of different components of the lateral flow assays (LFAs) on the flow. The velocity and concentration fields of LFAs are analyzed after adding PDMS hydrophobic barrier in the NC membrane. The modified lateral flow assays can obtain improved performance. The results can provide theoretical guidance for the design of the lateral flow assays.

AB - Based on the Brinkman equation and the chemical reaction equation, a 3D fluid-reaction coupling numerical model is built to study the effects of material properties of different components of the lateral flow assays (LFAs) on the flow. The velocity and concentration fields of LFAs are analyzed after adding PDMS hydrophobic barrier in the NC membrane. The modified lateral flow assays can obtain improved performance. The results can provide theoretical guidance for the design of the lateral flow assays.

KW - Convection-diffusion-reaction model

KW - Lateral flow assays

KW - PDMS hydrophobic barrier

UR - https://www.scopus.com/pages/publications/85087152532

M3 - 文章

AN - SCOPUS:85087152532

SN - 0253-231X

VL - 41

SP - 1524

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JO - Kung Cheng Je Wu Li Hsueh Pao/Journal of Engineering Thermophysics

JF - Kung Cheng Je Wu Li Hsueh Pao/Journal of Engineering Thermophysics

IS - 6

ER -

Simulation Study on Improving the Performance of Lateral Flow Assays by Adding Hydrophobic Barriers

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