TY - JOUR
T1 - Short-term effects of various ozone metrics on cardiopulmonary function in chronic obstructive pulmonary disease patients
T2 - Results from a panel study in Beijing, China
AU - Li, Hongyu
AU - Wu, Shaowei
AU - Pan, Lu
AU - Xu, Junhui
AU - Shan, Jiao
AU - Yang, Xuan
AU - Dong, Wei
AU - Deng, Furong
AU - Chen, Yahong
AU - Shima, Masayuki
AU - Guo, Xinbiao
N1 - Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2018/1
Y1 - 2018/1
N2 - Background Short-term exposure to ambient air pollution has been associated with lower pulmonary function and higher blood pressure (BP). However, controversy remains regarding the relationship between ambient multiple daily ozone (O3) metrics and cardiopulmonary health outcomes, especially in the developing countries. Objectives To investigate and compare the short-term effects of various O3 metrics on pulmonary function, fractional exhaled nitric oxide (FeNO) and BP in a panel study of COPD patients. Methods We measured pulmonary function, FeNO and BP repeatedly in a total of 43 patients with COPD for 215 home visits. Daily hourly ambient O3 concentrations were obtained from central-monitoring stations close to subject residences. We calculated various O3 metrics [daily 1-h maximum (O3-1 h max), maximum 8-h average (O3-8 h max) and 24-h average (O3-24 h avg)] based on the hourly data. Daily indoor O3 concentrations were estimated based on estimated indoor/outdoor O3 ratios. Linear mixed-effects models were used to estimate associations of various O3 metrics with cardiopulmonary function variables. Results An interquartile range (IQR) increase in ambient O3-8 h max (80.5 μg/m3, 5-d) was associated with a 5.9% (95%CI: −11.0%, −0.7%) reduction in forced expiratory volume in 1 s (FEV1) and a 6.2% (95%CI: −10.9%, −1.5%) reduction in peak expiratory flow (PEF). However, there were no significant negative associations between ambient O3-1 h max, O3-24 h avg and FEV1, PEF. An IQR increase in ambient O3-1 h max (85.3 μg/m3, 6-d) was associated with a 6.7 mmHg (95%CI: 0.7, 12.7) increase in systolic BP. The estimated indoor O3 were still significantly associated with reduction of FEV1 and PEF. No significant associations were found between various O3 metrics and FeNO. Conclusions Our results provide clues for the adverse cardiopulmonary effects associated with various O3 metrics in COPD patients and highlight that O3-8 h max was more closely associated with respiratory health variables. O3 exposure can pose threat to respiratory health with pollution level lower than the national O3 standard in Beijing, China.
AB - Background Short-term exposure to ambient air pollution has been associated with lower pulmonary function and higher blood pressure (BP). However, controversy remains regarding the relationship between ambient multiple daily ozone (O3) metrics and cardiopulmonary health outcomes, especially in the developing countries. Objectives To investigate and compare the short-term effects of various O3 metrics on pulmonary function, fractional exhaled nitric oxide (FeNO) and BP in a panel study of COPD patients. Methods We measured pulmonary function, FeNO and BP repeatedly in a total of 43 patients with COPD for 215 home visits. Daily hourly ambient O3 concentrations were obtained from central-monitoring stations close to subject residences. We calculated various O3 metrics [daily 1-h maximum (O3-1 h max), maximum 8-h average (O3-8 h max) and 24-h average (O3-24 h avg)] based on the hourly data. Daily indoor O3 concentrations were estimated based on estimated indoor/outdoor O3 ratios. Linear mixed-effects models were used to estimate associations of various O3 metrics with cardiopulmonary function variables. Results An interquartile range (IQR) increase in ambient O3-8 h max (80.5 μg/m3, 5-d) was associated with a 5.9% (95%CI: −11.0%, −0.7%) reduction in forced expiratory volume in 1 s (FEV1) and a 6.2% (95%CI: −10.9%, −1.5%) reduction in peak expiratory flow (PEF). However, there were no significant negative associations between ambient O3-1 h max, O3-24 h avg and FEV1, PEF. An IQR increase in ambient O3-1 h max (85.3 μg/m3, 6-d) was associated with a 6.7 mmHg (95%CI: 0.7, 12.7) increase in systolic BP. The estimated indoor O3 were still significantly associated with reduction of FEV1 and PEF. No significant associations were found between various O3 metrics and FeNO. Conclusions Our results provide clues for the adverse cardiopulmonary effects associated with various O3 metrics in COPD patients and highlight that O3-8 h max was more closely associated with respiratory health variables. O3 exposure can pose threat to respiratory health with pollution level lower than the national O3 standard in Beijing, China.
KW - Ambient ozone
KW - Blood pressure
KW - Cardiopulmonary
KW - Chronic obstructive pulmonary disease
KW - Pulmonary function
UR - https://www.scopus.com/pages/publications/85030654757
U2 - 10.1016/j.envpol.2017.09.030
DO - 10.1016/j.envpol.2017.09.030
M3 - 文章
C2 - 28987568
AN - SCOPUS:85030654757
SN - 0269-7491
VL - 232
SP - 358
EP - 366
JO - Environmental Pollution
JF - Environmental Pollution
ER -