Short-term effects of air pollution on cause-specific mental disorders in three subtropical Chinese cities

Background: The effects of ambient air pollution on specific mental disorders are rarely studied, and the reported results are inconsistent. Objective: To assess the short-term effect of ambient air pollution on the morbidity of mental disorders in three subtropical Chinese cities. Methods: Daily concentrations of air pollution were averaged from 19 fixed monitoring stations across each city, and data on patients were collected from three psychiatric specialty hospitals. A time-series study combined with a generalized additive Poisson model was conducted to investigate the association between air pollution and mental disorders. The exposure-response relationships were explored and stratified analyses by age and sex were conducted. Results: A total of 1,133,220 outpatient visits were recorded in three subtropical cities (Huizhou, Shenzhen, and Zhaoqing). The number of daily outpatient visits for mental disorders increased with higher air pollutant (PM_2.5, PM₁₀, SO₂ and NO₂) concentrations, and the effect of NO₂ appeared to be consistently significant across the three cities, with excess risk (ER) of 4.45% (95% CI: 2.90%, 6.04%) in Huizhou, 7.94% (95% CI: 6.28%, 9.62%) in Shenzhen, and 2.19% (95% CI: 0.51%, 3.89%) in Zhaoqing, respectively, at lag03. We also observed significant effect of PM_2.5 at lag0 (ER = 1.20%, 95% CI: 0.28%, 2.13%), PM₁₀ at lag0 (ER = 0.99%, 95% CI: 0.36%, 1.62%), and SO₂ at lag0 (ER = 10.74%, 95% CI: 3.20%, 18.84%) in Shenzhen. For specific mental disorders, significant associations were found in all the air pollutants except between SO₂ and affective disorder and between PM_2.5 and schizophrenia. In addition, we found that air pollution exhibited stronger effects for males and adults (≥18 years). Conclusion: Acute exposure to air pollution, especially NO₂, might be an important trigger of mental disorders.