TY - JOUR
T1 - Sex- and age-related trajectories of the adult human gut microbiota shared across populations of different ethnicities
AU - Zhang, Xiuying
AU - Zhong, Huanzi
AU - Li, Yufeng
AU - Shi, Zhun
AU - Ren, Huahui
AU - Zhang, Zhe
AU - Zhou, Xianghai
AU - Tang, Shanmei
AU - Han, Xueyao
AU - Lin, Yuxiang
AU - Yang, Fangming
AU - Wang, Dan
AU - Fang, Chao
AU - Fu, Zuodi
AU - Wang, Lianying
AU - Zhu, Shida
AU - Hou, Yong
AU - Xu, Xun
AU - Yang, Huanming
AU - Wang, Jian
AU - Kristiansen, Karsten
AU - Li, Junhua
AU - Ji, Linong
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2021/1
Y1 - 2021/1
N2 - Lifelong sex- and age-related trajectories of the human gut microbiota remain largely unexplored. Using metagenomics, we derived the gut microbial composition of 2,338 adults (26–76 years) from a Han Chinese population-based cohort where metabolic health, hormone levels and aspects of their lifestyles were also recorded. In this cohort, and in three independent cohorts distributed across China, Israel and the Netherlands, we observed sex differences in the gut microbial composition and a shared age-related decrease in sex-dependent differences in gut microbiota. Compared to men, the gut microbiota of premenopausal women exhibited higher microbial diversity and higher abundances of multiple species known to have beneficial effects on host metabolism. We also found consistent sex-independent, age-related gut microbial characteristics across all populations, with the presence of members of the oral microbiota being the strongest indicator of older chronological age. Our findings highlight the existence of sex- and age-related trajectories in the human gut microbiota that are shared between populations of different ethnicities and emphasize the pivotal links between sex hormones, gut microbiota and host metabolism.
AB - Lifelong sex- and age-related trajectories of the human gut microbiota remain largely unexplored. Using metagenomics, we derived the gut microbial composition of 2,338 adults (26–76 years) from a Han Chinese population-based cohort where metabolic health, hormone levels and aspects of their lifestyles were also recorded. In this cohort, and in three independent cohorts distributed across China, Israel and the Netherlands, we observed sex differences in the gut microbial composition and a shared age-related decrease in sex-dependent differences in gut microbiota. Compared to men, the gut microbiota of premenopausal women exhibited higher microbial diversity and higher abundances of multiple species known to have beneficial effects on host metabolism. We also found consistent sex-independent, age-related gut microbial characteristics across all populations, with the presence of members of the oral microbiota being the strongest indicator of older chronological age. Our findings highlight the existence of sex- and age-related trajectories in the human gut microbiota that are shared between populations of different ethnicities and emphasize the pivotal links between sex hormones, gut microbiota and host metabolism.
UR - https://www.scopus.com/pages/publications/85101919244
U2 - 10.1038/s43587-020-00014-2
DO - 10.1038/s43587-020-00014-2
M3 - 文章
AN - SCOPUS:85101919244
SN - 2662-8465
VL - 1
SP - 87
EP - 100
JO - Nature Aging
JF - Nature Aging
IS - 1
ER -
可持续发展目标 3 良好健康与福祉