TY - JOUR
T1 - Serum reference interval of ARCHITECT alpha-fetoprotein in healthy Chinese Han adults
T2 - Sub-analysis of a prospective multi-center study
AU - Yan, Cunling
AU - Yang, Jia
AU - Wei, Lianhua
AU - Hu, Jian
AU - Song, Jiaqi
AU - Wang, Xiaoqin
AU - Han, Ruilin
AU - Huang, Ying
AU - Zhang, Wei
AU - Soh, Andrew
AU - Beshiri, Agim
AU - Fan, Zhuping
AU - Zheng, Yijie
AU - Chen, Wei
N1 - Publisher Copyright:
© 2017 The Canadian Society of Clinical Chemists
PY - 2018/2
Y1 - 2018/2
N2 - Objectives Alpha-fetoprotein (AFP) has been widely used in clinical practice for decades. However, large-scale survey of serum reference interval for ARCHITECT AFP is still absent in Chinese population. This study aimed to measure serum AFP levels in healthy Chinese Han subjects, which is a sub-analysis of an ongoing prospective, cross-sectional, multi-center study (ClinicalTrials.gov Identifier: NCT03047603). Methods This analysis included a total of 530 participants (41.43 ± 12.14 years of age on average, 48.49% males), enrolled from 5 regional centers. Serum AFP level was measured by ARCHITECT immunoassay. Statistical analysis was performed using SAS 9.4 and R software. Results AFP distribution did not show significant correlation with age or sex. The overall median and interquartile range of AFP was 2.87 (2.09, 3.83) ng/mL. AFP level did not show a trend of increasing with age. The new reference interval was 2.0–7.07 ng/mL (LOQ– 97.5th percentiles). Conclusions The reference interval for ARCHITECT AFP is updated with the data of adequate number of healthy Han adults. This new reference interval is more practical and applicable in Chinese adults.
AB - Objectives Alpha-fetoprotein (AFP) has been widely used in clinical practice for decades. However, large-scale survey of serum reference interval for ARCHITECT AFP is still absent in Chinese population. This study aimed to measure serum AFP levels in healthy Chinese Han subjects, which is a sub-analysis of an ongoing prospective, cross-sectional, multi-center study (ClinicalTrials.gov Identifier: NCT03047603). Methods This analysis included a total of 530 participants (41.43 ± 12.14 years of age on average, 48.49% males), enrolled from 5 regional centers. Serum AFP level was measured by ARCHITECT immunoassay. Statistical analysis was performed using SAS 9.4 and R software. Results AFP distribution did not show significant correlation with age or sex. The overall median and interquartile range of AFP was 2.87 (2.09, 3.83) ng/mL. AFP level did not show a trend of increasing with age. The new reference interval was 2.0–7.07 ng/mL (LOQ– 97.5th percentiles). Conclusions The reference interval for ARCHITECT AFP is updated with the data of adequate number of healthy Han adults. This new reference interval is more practical and applicable in Chinese adults.
KW - Alpha-fetoprotein
KW - Hepatocellular carcinoma
KW - Reference interval
UR - https://www.scopus.com/pages/publications/85034448475
U2 - 10.1016/j.clinbiochem.2017.11.002
DO - 10.1016/j.clinbiochem.2017.11.002
M3 - 文章
C2 - 29129627
AN - SCOPUS:85034448475
SN - 0009-9120
VL - 52
SP - 164
EP - 166
JO - Clinical Biochemistry
JF - Clinical Biochemistry
ER -