Sequencing of 50 human exomes reveals adaptation to high altitude

Xin Yi; Yu Liang; Emilia Huerta-Sanchez; Xin Jin; Zha Xi Ping Cuo; John E. Pool; N. Xu; Hui Jiang; Nicolas Vinckenbosch; Thorfinn Sand Korneliussen; Hancheng Zheng; Tao Liu; Weiming He; Kui Li; Ruibang Luo; Xifang Nie; Honglong Wu; Meiru Zhao; Hongzhi Cao; Jing Zou; Ying Shan; Shuzheng Li; Qi Yang; Asan; Peixiang Ni; Geng Tian; Junming Xu; Xiao Liu; Tao Jiang; Renhua Wu; Guangyu Zhou; Meifang Tang; Junjie Qin; Tong Wang; Shuijian Feng; Guohong Li; Huasang; Jiangbai Luosang; Wei Wang; Fang Chen; Yading Wang; Xiaoguang Zheng; Zhuo Li; Zhuoma Bianba; Ge Yang; Xinping Wang; Shuhui Tang; Guoyi Gao; Yong Chen; Zhen Luo; Lamu Gusang; Zheng Cao; Qinghui Zhang; Weihan Ouyang; Xiaoli Ren; Huiqing Liang; Huisong Zheng; Yebo Huang; Jingxiang Li; Lars Bolund; Karsten Kristiansen; Yingrui Li; Yong Zhang; Xiuqing Zhang; Ruiqiang Li; Songgang Li; Huanming Yang; Rasmus Nielsen; Jun Wang; Jian Wang

doi:10.1126/science.1190371

Sequencing of 50 human exomes reveals adaptation to high altitude

Xin Yi
, Yu Liang
, Emilia Huerta-Sanchez
, Xin Jin
, Zha Xi Ping Cuo
, John E. Pool
, N. Xu
, Hui Jiang
, Nicolas Vinckenbosch
, Thorfinn Sand Korneliussen
, Hancheng Zheng
, Tao Liu
, Weiming He
, Kui Li
, Ruibang Luo
, Xifang Nie
, Honglong Wu
, Meiru Zhao
, Hongzhi Cao
, Jing Zou

Ying Shan, Shuzheng Li, Qi Yang, Asan, Peixiang Ni, Geng Tian, Junming Xu, Xiao Liu, Tao Jiang, Renhua Wu, Guangyu Zhou, Meifang Tang, Junjie Qin, Tong Wang, Shuijian Feng, Guohong Li, Huasang, Jiangbai Luosang, Wei Wang, Fang Chen, Yading Wang, Xiaoguang Zheng, Zhuo Li, Zhuoma Bianba, Ge Yang, Xinping Wang, Shuhui Tang, Guoyi Gao, Yong Chen, Zhen Luo, Lamu Gusang, Zheng Cao, Qinghui Zhang, Weihan Ouyang, Xiaoli Ren, Huiqing Liang, Huisong Zheng, Yebo Huang, Jingxiang Li, Lars Bolund, Karsten Kristiansen, Yingrui Li, Yong Zhang, Xiuqing Zhang, Ruiqiang Li, Songgang Li, Huanming Yang, Rasmus Nielsen, Jun Wang, Jian Wang

BGI-Shenzhen
University of Chinese Academy of Sciences
University of California at Berkeley
South China University of Technology
People's Hospital of the Tibet Autonomous Region
University of California at Davis
University of Copenhagen
Shenzhen University
People's Hospital
Military General Hospital of Tibet
Hospital of XiShuangBanNa Dai Nationalities

科研成果: 期刊稿件 › 文章 › 同行评审

1355 引用（Scopus）

摘要

Residents of the Tibetan Plateau show heritable adaptations to extreme altitude. We sequenced 50 exornes of ethnic Tibetans, encompassing coding sequences of 92% of human genes, with an average coverage of 18x per individual. Genes showing population-specific allele frequency changes, which represent strong candidates for altitude adaptation, were identified. The strongest signal of natural selection came from endothelial Per-Arnt-Sim (PAS) domain protein 1 (EPAS1), a transcription factor involved in response to hypoxia. One single-nucleotide polymorphism (SNP) at EPASl shows a 78% frequency difference between Tibetan and Han samples, representing the fastest allele frequency change observed at any human gene to date. This SNP's association with erythrocyte abundance supports the role of EPASl in adaptation to hypoxia. Thus, a population genomic survey has revealed a functionally important locus in genetic adaptation to high altitude.

源语言	英语
页（从-至）	75-78
页数	4
期刊	Science
卷	329
期	5987
DOI	https://doi.org/10.1126/science.1190371
出版状态	已出版 - 2 7月 2010
已对外发布	是

访问文件

10.1126/science.1190371

其它文件与链接

链接到 Scopus 的出版物

引用此

@article{7e6c9ae8d25c4f46be6aada67bb03375,

title = "Sequencing of 50 human exomes reveals adaptation to high altitude",

abstract = "Residents of the Tibetan Plateau show heritable adaptations to extreme altitude. We sequenced 50 exornes of ethnic Tibetans, encompassing coding sequences of 92\% of human genes, with an average coverage of 18x per individual. Genes showing population-specific allele frequency changes, which represent strong candidates for altitude adaptation, were identified. The strongest signal of natural selection came from endothelial Per-Arnt-Sim (PAS) domain protein 1 (EPAS1), a transcription factor involved in response to hypoxia. One single-nucleotide polymorphism (SNP) at EPASl shows a 78\% frequency difference between Tibetan and Han samples, representing the fastest allele frequency change observed at any human gene to date. This SNP's association with erythrocyte abundance supports the role of EPASl in adaptation to hypoxia. Thus, a population genomic survey has revealed a functionally important locus in genetic adaptation to high altitude.",

author = "Xin Yi and Yu Liang and Emilia Huerta-Sanchez and Xin Jin and Cuo, \{Zha Xi Ping\} and Pool, \{John E.\} and N. Xu and Hui Jiang and Nicolas Vinckenbosch and Korneliussen, \{Thorfinn Sand\} and Hancheng Zheng and Tao Liu and Weiming He and Kui Li and Ruibang Luo and Xifang Nie and Honglong Wu and Meiru Zhao and Hongzhi Cao and Jing Zou and Ying Shan and Shuzheng Li and Qi Yang and Asan and Peixiang Ni and Geng Tian and Junming Xu and Xiao Liu and Tao Jiang and Renhua Wu and Guangyu Zhou and Meifang Tang and Junjie Qin and Tong Wang and Shuijian Feng and Guohong Li and Huasang and Jiangbai Luosang and Wei Wang and Fang Chen and Yading Wang and Xiaoguang Zheng and Zhuo Li and Zhuoma Bianba and Ge Yang and Xinping Wang and Shuhui Tang and Guoyi Gao and Yong Chen and Zhen Luo and Lamu Gusang and Zheng Cao and Qinghui Zhang and Weihan Ouyang and Xiaoli Ren and Huiqing Liang and Huisong Zheng and Yebo Huang and Jingxiang Li and Lars Bolund and Karsten Kristiansen and Yingrui Li and Yong Zhang and Xiuqing Zhang and Ruiqiang Li and Songgang Li and Huanming Yang and Rasmus Nielsen and Jun Wang and Jian Wang",

year = "2010",

month = jul,

day = "2",

doi = "10.1126/science.1190371",

language = "英语",

volume = "329",

pages = "75--78",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5987",

}

Yi, X, Liang, Y, Huerta-Sanchez, E, Jin, X, Cuo, ZXP, Pool, JE, Xu, N, Jiang, H, Vinckenbosch, N, Korneliussen, TS, Zheng, H, Liu, T, He, W, Li, K, Luo, R, Nie, X, Wu, H, Zhao, M, Cao, H, Zou, J, Shan, Y, Li, S, Yang, Q, Asan, Ni, P, Tian, G, Xu, J, Liu, X, Jiang, T, Wu, R, Zhou, G, Tang, M, Qin, J, Wang, T, Feng, S, Li, G, Huasang, Luosang, J, Wang, W, Chen, F, Wang, Y, Zheng, X, Li, Z, Bianba, Z, Yang, G, Wang, X, Tang, S, Gao, G, Chen, Y, Luo, Z, Gusang, L, Cao, Z, Zhang, Q, Ouyang, W, Ren, X, Liang, H, Zheng, H, Huang, Y, Li, J, Bolund, L, Kristiansen, K, Li, Y, Zhang, Y, Zhang, X, Li, R, Li, S, Yang, H, Nielsen, R, Wang, J & Wang, J 2010, 'Sequencing of 50 human exomes reveals adaptation to high altitude', Science, 卷 329, 号码 5987, 页码 75-78. https://doi.org/10.1126/science.1190371

TY - JOUR

T1 - Sequencing of 50 human exomes reveals adaptation to high altitude

AU - Yi, Xin

AU - Liang, Yu

AU - Huerta-Sanchez, Emilia

AU - Jin, Xin

AU - Cuo, Zha Xi Ping

AU - Pool, John E.

AU - Xu, N.

AU - Jiang, Hui

AU - Vinckenbosch, Nicolas

AU - Korneliussen, Thorfinn Sand

AU - Zheng, Hancheng

AU - Liu, Tao

AU - He, Weiming

AU - Li, Kui

AU - Luo, Ruibang

AU - Nie, Xifang

AU - Wu, Honglong

AU - Zhao, Meiru

AU - Cao, Hongzhi

AU - Zou, Jing

AU - Shan, Ying

AU - Li, Shuzheng

AU - Yang, Qi

AU - Asan,

AU - Ni, Peixiang

AU - Tian, Geng

AU - Xu, Junming

AU - Liu, Xiao

AU - Jiang, Tao

AU - Wu, Renhua

AU - Zhou, Guangyu

AU - Tang, Meifang

AU - Qin, Junjie

AU - Wang, Tong

AU - Feng, Shuijian

AU - Li, Guohong

AU - Huasang,

AU - Luosang, Jiangbai

AU - Wang, Wei

AU - Chen, Fang

AU - Wang, Yading

AU - Zheng, Xiaoguang

AU - Li, Zhuo

AU - Bianba, Zhuoma

AU - Yang, Ge

AU - Wang, Xinping

AU - Tang, Shuhui

AU - Gao, Guoyi

AU - Chen, Yong

AU - Luo, Zhen

AU - Gusang, Lamu

AU - Cao, Zheng

AU - Zhang, Qinghui

AU - Ouyang, Weihan

AU - Ren, Xiaoli

AU - Liang, Huiqing

AU - Zheng, Huisong

AU - Huang, Yebo

AU - Li, Jingxiang

AU - Bolund, Lars

AU - Kristiansen, Karsten

AU - Li, Yingrui

AU - Zhang, Yong

AU - Zhang, Xiuqing

AU - Li, Ruiqiang

AU - Li, Songgang

AU - Yang, Huanming

AU - Nielsen, Rasmus

AU - Wang, Jun

AU - Wang, Jian

PY - 2010/7/2

Y1 - 2010/7/2

N2 - Residents of the Tibetan Plateau show heritable adaptations to extreme altitude. We sequenced 50 exornes of ethnic Tibetans, encompassing coding sequences of 92% of human genes, with an average coverage of 18x per individual. Genes showing population-specific allele frequency changes, which represent strong candidates for altitude adaptation, were identified. The strongest signal of natural selection came from endothelial Per-Arnt-Sim (PAS) domain protein 1 (EPAS1), a transcription factor involved in response to hypoxia. One single-nucleotide polymorphism (SNP) at EPASl shows a 78% frequency difference between Tibetan and Han samples, representing the fastest allele frequency change observed at any human gene to date. This SNP's association with erythrocyte abundance supports the role of EPASl in adaptation to hypoxia. Thus, a population genomic survey has revealed a functionally important locus in genetic adaptation to high altitude.

AB - Residents of the Tibetan Plateau show heritable adaptations to extreme altitude. We sequenced 50 exornes of ethnic Tibetans, encompassing coding sequences of 92% of human genes, with an average coverage of 18x per individual. Genes showing population-specific allele frequency changes, which represent strong candidates for altitude adaptation, were identified. The strongest signal of natural selection came from endothelial Per-Arnt-Sim (PAS) domain protein 1 (EPAS1), a transcription factor involved in response to hypoxia. One single-nucleotide polymorphism (SNP) at EPASl shows a 78% frequency difference between Tibetan and Han samples, representing the fastest allele frequency change observed at any human gene to date. This SNP's association with erythrocyte abundance supports the role of EPASl in adaptation to hypoxia. Thus, a population genomic survey has revealed a functionally important locus in genetic adaptation to high altitude.

UR - https://www.scopus.com/pages/publications/77954319020

U2 - 10.1126/science.1190371

DO - 10.1126/science.1190371

M3 - 文章

C2 - 20595611

AN - SCOPUS:77954319020

SN - 0036-8075

VL - 329

SP - 75

EP - 78

JO - Science

JF - Science

IS - 5987

ER -

Sequencing of 50 human exomes reveals adaptation to high altitude

摘要

访问文件

其它文件与链接

学术指纹

引用此