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Restoration of Cingulate Long-Term Depression by Enhancing Non-apoptotic Caspase 3 Alleviates Peripheral Pain Hypersensitivity

  • Yong Jie Wang
  • , Ming Gang Liu
  • , Jing Hua Wang
  • , Wei Cao
  • , Cheng Wu
  • , Zi Yue Wang
  • , Li Liu
  • , Fan Yang
  • , Zhi Hui Feng
  • , Li Sun
  • , Fuxing Zhang
  • , Yi Shen
  • , Yu Dong Zhou
  • , Min Zhuo
  • , Jian Hong Luo
  • , Tian Le Xu
  • , Xiang Yao Li
  • Sir Run Run Shaw Hospital
  • Zhejiang University
  • Xi'an Jiaotong University
  • Shanghai Jiao Tong University
  • Zhejiang University School of Medicine
  • Air Force Medical University
  • University of Toronto

科研成果: 期刊稿件文章同行评审

36 引用 (Scopus)

摘要

Wang et al. find that peripheral nerve injury prevents LTD induction in the anterior cingulate cortex (ACC) due to the downregulation of Casp3. Disrupting the interaction between Casp3 and AMPAR subunits inhibits LTD induction and induces peripheral pain hypersensitivity. Restoration of cingulate LTD rescues peripheral pain hypersensitivity.

源语言英语
文章编号108369
期刊Cell Reports
33
6
DOI
出版状态已出版 - 10 11月 2020

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