Regulation of macrophage migration in ischemic mouse hearts via an AKT2/NBA1/SPK1 pathway

Yanping Yang; Jieqiong Zhao; Juan Zhang; Yonghong Lei; Fang Yuan; Lu Liu; Haibo Gao; Hua Guo; Xiaolin Niu; Ruirui Chen; Xiaobing Fu; Yan Han; Hua Han; Tung Chan; Lianyou Zhao; Haichang Wang; Qiangsun Zheng; Xue Li

doi:10.18632/oncotarget.23263

Regulation of macrophage migration in ischemic mouse hearts via an AKT2/NBA1/SPK1 pathway

Yanping Yang
, Jieqiong Zhao
, Juan Zhang
, Yonghong Lei
, Fang Yuan
, Lu Liu
, Haibo Gao
, Hua Guo
, Xiaolin Niu
, Ruirui Chen
, Xiaobing Fu
, Yan Han
, Hua Han
, Tung Chan
, Lianyou Zhao
, Haichang Wang
, Qiangsun Zheng
, Xue Li

Tangdu Hospital, Fourth Military Medical University
General Hospital of People's Liberation Army
Chinese General Hospital
Air Force Medical University
Xibei Hospital

科研成果: 期刊稿件 › 文章 › 同行评审

2 引用（Scopus）

摘要

The role of the AKT2/NBA1/SPK1 signaling cascade in macrophage migration regulation and post-ischemic cardiac remodeling was investigated. We determined that the AKT2/NBA1/SPK1 signaling cascade regulated macrophage migration. A novel role for NBA1 in macrophage migration was discovered. Elevated AKT2 phosphorylation, NBA1, SPK1 (along with phosphorylated SPK1) levels, macrophage recruitment, apoptosis, and fibrosis were found within the infarct area. Atorvastatin had a beneficial effect on cardiac remodeling following myocardial infarction by inhibiting AKT2/NBA1/SPK1-mediated macrophage recruitment, apoptosis, and collagen deposition while increasing angiogenesis in the infarct area. Atorvastatin-related protection of cardiac remodeling following myocardial infarction was abolished in SPK1-KO mice. The AKT2/NAB1/SPK1 pathway is a novel regulating factor of macrophage migration and cardiac remodeling after myocardial infarction.

源语言	英语
页（从-至）	115345-115359
页数	15
期刊	Oncotarget
卷	8
期	70
DOI	https://doi.org/10.18632/oncotarget.23263
出版状态	已出版 - 2017
已对外发布	是

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10.18632/oncotarget.23263

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title = "Regulation of macrophage migration in ischemic mouse hearts via an AKT2/NBA1/SPK1 pathway",

abstract = "The role of the AKT2/NBA1/SPK1 signaling cascade in macrophage migration regulation and post-ischemic cardiac remodeling was investigated. We determined that the AKT2/NBA1/SPK1 signaling cascade regulated macrophage migration. A novel role for NBA1 in macrophage migration was discovered. Elevated AKT2 phosphorylation, NBA1, SPK1 (along with phosphorylated SPK1) levels, macrophage recruitment, apoptosis, and fibrosis were found within the infarct area. Atorvastatin had a beneficial effect on cardiac remodeling following myocardial infarction by inhibiting AKT2/NBA1/SPK1-mediated macrophage recruitment, apoptosis, and collagen deposition while increasing angiogenesis in the infarct area. Atorvastatin-related protection of cardiac remodeling following myocardial infarction was abolished in SPK1-KO mice. The AKT2/NAB1/SPK1 pathway is a novel regulating factor of macrophage migration and cardiac remodeling after myocardial infarction.",

keywords = "Atorvastatin, Cardiac function, Macrophage migration, Myocardial infarction",

author = "Yanping Yang and Jieqiong Zhao and Juan Zhang and Yonghong Lei and Fang Yuan and Lu Liu and Haibo Gao and Hua Guo and Xiaolin Niu and Ruirui Chen and Xiaobing Fu and Yan Han and Hua Han and Tung Chan and Lianyou Zhao and Haichang Wang and Qiangsun Zheng and Xue Li",

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year = "2017",

doi = "10.18632/oncotarget.23263",

language = "英语",

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pages = "115345--115359",

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T1 - Regulation of macrophage migration in ischemic mouse hearts via an AKT2/NBA1/SPK1 pathway

AU - Yang, Yanping

AU - Zhao, Jieqiong

AU - Zhang, Juan

AU - Lei, Yonghong

AU - Yuan, Fang

AU - Liu, Lu

AU - Gao, Haibo

AU - Guo, Hua

AU - Niu, Xiaolin

AU - Chen, Ruirui

AU - Fu, Xiaobing

AU - Han, Yan

AU - Han, Hua

AU - Chan, Tung

AU - Zhao, Lianyou

AU - Wang, Haichang

AU - Zheng, Qiangsun

AU - Li, Xue

PY - 2017

Y1 - 2017

N2 - The role of the AKT2/NBA1/SPK1 signaling cascade in macrophage migration regulation and post-ischemic cardiac remodeling was investigated. We determined that the AKT2/NBA1/SPK1 signaling cascade regulated macrophage migration. A novel role for NBA1 in macrophage migration was discovered. Elevated AKT2 phosphorylation, NBA1, SPK1 (along with phosphorylated SPK1) levels, macrophage recruitment, apoptosis, and fibrosis were found within the infarct area. Atorvastatin had a beneficial effect on cardiac remodeling following myocardial infarction by inhibiting AKT2/NBA1/SPK1-mediated macrophage recruitment, apoptosis, and collagen deposition while increasing angiogenesis in the infarct area. Atorvastatin-related protection of cardiac remodeling following myocardial infarction was abolished in SPK1-KO mice. The AKT2/NAB1/SPK1 pathway is a novel regulating factor of macrophage migration and cardiac remodeling after myocardial infarction.

AB - The role of the AKT2/NBA1/SPK1 signaling cascade in macrophage migration regulation and post-ischemic cardiac remodeling was investigated. We determined that the AKT2/NBA1/SPK1 signaling cascade regulated macrophage migration. A novel role for NBA1 in macrophage migration was discovered. Elevated AKT2 phosphorylation, NBA1, SPK1 (along with phosphorylated SPK1) levels, macrophage recruitment, apoptosis, and fibrosis were found within the infarct area. Atorvastatin had a beneficial effect on cardiac remodeling following myocardial infarction by inhibiting AKT2/NBA1/SPK1-mediated macrophage recruitment, apoptosis, and collagen deposition while increasing angiogenesis in the infarct area. Atorvastatin-related protection of cardiac remodeling following myocardial infarction was abolished in SPK1-KO mice. The AKT2/NAB1/SPK1 pathway is a novel regulating factor of macrophage migration and cardiac remodeling after myocardial infarction.

KW - Atorvastatin

KW - Cardiac function

KW - Macrophage migration

KW - Myocardial infarction

UR - https://www.scopus.com/pages/publications/85039758727

U2 - 10.18632/oncotarget.23263

DO - 10.18632/oncotarget.23263

M3 - 文章

C2 - 29383164

AN - SCOPUS:85039758727

SN - 1949-2553

VL - 8

SP - 115345

EP - 115359

JO - Oncotarget

JF - Oncotarget

IS - 70

ER -

Regulation of macrophage migration in ischemic mouse hearts via an AKT2/NBA1/SPK1 pathway

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