Recent advance in aminopeptidase N (APN/CD13) inhibitor research

X. Zhang; H. Fang; J. Zhang; Y. Yuan; W. Xu

doi:10.2174/092986711797535155

Recent advance in aminopeptidase N (APN/CD13) inhibitor research

X. Zhang
, H. Fang
, J. Zhang
, Y. Yuan
, W. Xu

Shandong University

科研成果: 期刊稿件 › 文章 › 同行评审

27 引用（Scopus）

摘要

APN is an important zinc dependent metallo-exopeptidase, which can degrade the extracellular matrix, and plays an important role in tumor invasion, metastasis and angiogenesis. it has been considered as a suitable target for anti-cancer drug design. Recently, research of structure-based APN inhibitors is becoming an interesting field, and many APN inhibitors have been reported. Here we review a series of APN inhibitors and the recent progress in this field.

源语言	英语
页（从-至）	5011-5021
页数	11
期刊	Current Medicinal Chemistry
卷	18
期	32
DOI	https://doi.org/10.2174/092986711797535155
出版状态	已出版 - 11月 2011
已对外发布	是

联合国可持续发展目标

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10.2174/092986711797535155

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abstract = "APN is an important zinc dependent metallo-exopeptidase, which can degrade the extracellular matrix, and plays an important role in tumor invasion, metastasis and angiogenesis. it has been considered as a suitable target for anti-cancer drug design. Recently, research of structure-based APN inhibitors is becoming an interesting field, and many APN inhibitors have been reported. Here we review a series of APN inhibitors and the recent progress in this field.",

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AU - Fang, H.

AU - Zhang, J.

AU - Yuan, Y.

AU - Xu, W.

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AB - APN is an important zinc dependent metallo-exopeptidase, which can degrade the extracellular matrix, and plays an important role in tumor invasion, metastasis and angiogenesis. it has been considered as a suitable target for anti-cancer drug design. Recently, research of structure-based APN inhibitors is becoming an interesting field, and many APN inhibitors have been reported. Here we review a series of APN inhibitors and the recent progress in this field.

KW - Aminopeptidase N

KW - Anti-tumor

KW - Inhibitors

KW - Peptidomimetics

KW - Rational drug design

KW - Structure activity relationship

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ER -

Recent advance in aminopeptidase N (APN/CD13) inhibitor research

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