Radiation effect on unresectable pancreatic carcinoma through ¹²⁵ I seeds implantation

Objective: To investigate the therapeutic effect of ¹²⁵I particles implantation in the treatment of unresectable pancreatic carcinoma. Methods: Fifty cases of pancreatic carcinoma were chosen in the trial, 30 of them were treated by ¹²⁵I seeds implantation accompanied with or without choledoenteroanastomosis and (or) gastrojejunostomy, and 20 cases treated with choas the choledoenteroanastomosis and (or) gastrojejunostomy. The peri-operative hepatic function, serum bilirubin, the size of the tumor, complications and the intensity of pain were observered. Results: The total bilirubin decreased to normal level 4 weeks after the operation, while the liver function recovered in the cases of both the groups. Nearly all the 30 of radiotherapy cases (100%) had a perfect remission of the abdominal and back painfulness, and the CR rate was 97%. No obvious complications occurred, and tumor seemed to be smaller then. Conclusions: ¹²⁵I seeds implantation has an obvious therapeutic effect to those cases of unresectable pancreatic carcinoma. It can prolong the survival period, improve the quality of life, and relieve pain obviously.