Prognostic and clinicopathological role of long noncoding RNA NORAD in various cancers: A meta-analysis

Qingting Wang; Qianqian Zhang; Jian Wang; Wei Feng; Yuqian Chen; Jin Liu; Zhan Qu; Manxiang Li

doi:10.2217/bmm-2020-0566

Prognostic and clinicopathological role of long noncoding RNA NORAD in various cancers: A meta-analysis

Qingting Wang
, Qianqian Zhang
, Jian Wang
, Wei Feng
, Yuqian Chen
, Jin Liu
, Zhan Qu
, Manxiang Li

The First Affiliated Hospital of Xi’an Jiaotong University

科研成果: 期刊稿件 › 文章 › 同行评审

4 引用（Scopus）

摘要

Aim: Long noncoding RNA (lncRNA) noncoding RNA activated by DNA damage (NORAD) is widely investigated in different tumors. Our meta-analysis intends to assess the prognostic and clinicopathological value of NORAD in cancers. Materials & methods: We searched PubMed, Web of Science, Embase and Chinese National Knowledge Infrastructure from inception to 1 August 2020. Results: The results showed that higher expression of NORAD had a significant association with worse overall survival. Additionally, correlations were detected between elevated level of NORAD and poor differentiation degree, positive lymph node metastasis and large tumor size in cancer patients. Conclusion: LncRNA NORAD can serve as a novel and promising biomarker for prognosis and clinicopathological characteristics in different cancers.

源语言	英语
页（从-至）	427-436
页数	10
期刊	Biomarkers in medicine
卷	15
期	6
DOI	https://doi.org/10.2217/bmm-2020-0566
出版状态	已出版 - 4月 2021
已对外发布	是

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@article{5d3cb7f8509b49079fd44a9204ff1723,

title = "Prognostic and clinicopathological role of long noncoding RNA NORAD in various cancers: A meta-analysis",

abstract = "Aim: Long noncoding RNA (lncRNA) noncoding RNA activated by DNA damage (NORAD) is widely investigated in different tumors. Our meta-analysis intends to assess the prognostic and clinicopathological value of NORAD in cancers. Materials \& methods: We searched PubMed, Web of Science, Embase and Chinese National Knowledge Infrastructure from inception to 1 August 2020. Results: The results showed that higher expression of NORAD had a significant association with worse overall survival. Additionally, correlations were detected between elevated level of NORAD and poor differentiation degree, positive lymph node metastasis and large tumor size in cancer patients. Conclusion: LncRNA NORAD can serve as a novel and promising biomarker for prognosis and clinicopathological characteristics in different cancers.",

keywords = "NORAD, clinicopathological features, meta-analysis, prognosis, tumor",

author = "Qingting Wang and Qianqian Zhang and Jian Wang and Wei Feng and Yuqian Chen and Jin Liu and Zhan Qu and Manxiang Li",

note = "Publisher Copyright: {\textcopyright} 2021 ",

year = "2021",

month = apr,

doi = "10.2217/bmm-2020-0566",

language = "英语",

volume = "15",

pages = "427--436",

journal = "Biomarkers in medicine",

issn = "1752-0371",

publisher = "Taylor and Francis Ltd.",

number = "6",

}

TY - JOUR

T1 - Prognostic and clinicopathological role of long noncoding RNA NORAD in various cancers

T2 - A meta-analysis

AU - Wang, Qingting

AU - Zhang, Qianqian

AU - Wang, Jian

AU - Feng, Wei

AU - Chen, Yuqian

AU - Liu, Jin

AU - Qu, Zhan

AU - Li, Manxiang

PY - 2021/4

Y1 - 2021/4

N2 - Aim: Long noncoding RNA (lncRNA) noncoding RNA activated by DNA damage (NORAD) is widely investigated in different tumors. Our meta-analysis intends to assess the prognostic and clinicopathological value of NORAD in cancers. Materials & methods: We searched PubMed, Web of Science, Embase and Chinese National Knowledge Infrastructure from inception to 1 August 2020. Results: The results showed that higher expression of NORAD had a significant association with worse overall survival. Additionally, correlations were detected between elevated level of NORAD and poor differentiation degree, positive lymph node metastasis and large tumor size in cancer patients. Conclusion: LncRNA NORAD can serve as a novel and promising biomarker for prognosis and clinicopathological characteristics in different cancers.

AB - Aim: Long noncoding RNA (lncRNA) noncoding RNA activated by DNA damage (NORAD) is widely investigated in different tumors. Our meta-analysis intends to assess the prognostic and clinicopathological value of NORAD in cancers. Materials & methods: We searched PubMed, Web of Science, Embase and Chinese National Knowledge Infrastructure from inception to 1 August 2020. Results: The results showed that higher expression of NORAD had a significant association with worse overall survival. Additionally, correlations were detected between elevated level of NORAD and poor differentiation degree, positive lymph node metastasis and large tumor size in cancer patients. Conclusion: LncRNA NORAD can serve as a novel and promising biomarker for prognosis and clinicopathological characteristics in different cancers.

KW - NORAD

KW - clinicopathological features

KW - meta-analysis

KW - prognosis

KW - tumor

UR - https://www.scopus.com/pages/publications/85103612480

U2 - 10.2217/bmm-2020-0566

DO - 10.2217/bmm-2020-0566

M3 - 文章

C2 - 33709782

AN - SCOPUS:85103612480

SN - 1752-0371

VL - 15

SP - 427

EP - 436

JO - Biomarkers in medicine

JF - Biomarkers in medicine

IS - 6

ER -

Prognostic and clinicopathological role of long noncoding RNA NORAD in various cancers: A meta-analysis

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