Phosphoinositide signaling at the cytoskeleton in the regulation of cell dynamics

The cytoskeleton, composed of microfilaments, intermediate filaments, and microtubules, provides the structural basis for cellular functions such as motility and adhesion. Equally crucial, phosphoinositide (PIP_n) signaling is a critical regulator of these processes and other biological activities, though its precise impact on cytoskeletal dynamics has yet to be systematically investigated. This review explores the complex interplay between PIP_n signaling and the cytoskeleton, detailing how PIP_n modulates the dynamics of actin, intermediate filaments, and microtubules to shape cellular behavior. Dysregulation of PIP_n signaling is implicated in various diseases, including cancer, highlighting promising therapeutic opportunities through targeted modulation of these pathways. Future research should aim to elucidate the intricate molecular interactions and broader cellular responses to PIP_n signaling perturbations, particularly in disease contexts, to devise effective strategies for restoring cytoskeletal integrity.