TY - JOUR
T1 - Pharmacokinetics of a novel antihypertension candidate ATPT in Beagle dogs
AU - Feng, Dong
AU - Sun, Jianguo
AU - Zhu, Yinci
AU - Peng, Ying
AU - Qi, Huanhuan
AU - Zhang, Fengyi
AU - Wang, Guangji
PY - 2013/4
Y1 - 2013/4
N2 - An LC-MS/MS method was used for the evaluation of a novel antihypertension candidate pharmacokinetics of ATPT in Beagle dogs. After ig administration of 7.5, 15 and 30 mg/kg ATPT, the determined tmax and t1/2of ATPT in dogs were 0.7-1.0 h and 3.5-4.3 h, respectively. While the areas under the curve (AUC0-∞) were (5 465.9±1 748.7), (7 846.2±3 547.4) and (15 490.9±8 292.4) ng·h/mL at three doses, respectively. Good linearity was observed between cmax/ AUC0-∞ and dose (R2 > 0.98) after a single ig administration of 7.5, 15 and 30 mg/kg in dogs. After adjustment of dose, the absolute bioavailabilities of ATPT in dogs were 39.7%, 28.5% and 28.1%, respectively. It presented a linear pharmacokinetics for ATPT in Beagle dogs within the dose range of the study.
AB - An LC-MS/MS method was used for the evaluation of a novel antihypertension candidate pharmacokinetics of ATPT in Beagle dogs. After ig administration of 7.5, 15 and 30 mg/kg ATPT, the determined tmax and t1/2of ATPT in dogs were 0.7-1.0 h and 3.5-4.3 h, respectively. While the areas under the curve (AUC0-∞) were (5 465.9±1 748.7), (7 846.2±3 547.4) and (15 490.9±8 292.4) ng·h/mL at three doses, respectively. Good linearity was observed between cmax/ AUC0-∞ and dose (R2 > 0.98) after a single ig administration of 7.5, 15 and 30 mg/kg in dogs. After adjustment of dose, the absolute bioavailabilities of ATPT in dogs were 39.7%, 28.5% and 28.1%, respectively. It presented a linear pharmacokinetics for ATPT in Beagle dogs within the dose range of the study.
KW - ATPT
KW - Angiotensin II type 1 receptor antagonist
KW - Antihypertension candidate
KW - LC/MS/MS
KW - Pharmacokinetics
UR - https://www.scopus.com/pages/publications/84878059964
M3 - 文章
AN - SCOPUS:84878059964
SN - 1000-5048
VL - 44
SP - 151
EP - 155
JO - Journal of China Pharmaceutical University
JF - Journal of China Pharmaceutical University
IS - 2
ER -