TY - JOUR
T1 - Pharmacokinetic and absolute bioavailability study of total panax notoginsenoside, a typical multiple constituent traditional Chinese medicine (TCM) in rats
AU - Li, Xiaoyu
AU - Wang, Guangji
AU - Sun, Jianguo
AU - Hao, Haiping
AU - Xiong, Yuqing
AU - Yan, Bei
AU - Zheng, Yuanting
AU - Sheng, Longsheng
PY - 2007/5
Y1 - 2007/5
N2 - LC/ESI/MS method was employed for the pharmacokinetic evaluation of total panax notoginsenoside (TPNS) in rats. After oral or intravenous administration of TPNS at the dosage of 300.0 or 10.0 mg kg-1 to rats respectively, panax notoginsenoside R1, ginsenoside Rg1, Rd, Re and Rb1 were simultaneous determined in rat plasma. Pharmacokinetic parameters and absolute bioavailability of panax notoginsenoside R1, ginsenoside Rg1, Rd, Re and Rb1 were obtained by the Drug And Statistics for windows (DAS) pharmacokinetic software. The pharmacokinetic parameters of all analytes were different form each other. T1/2 were changed from 0.72 to 22.16 h and AUC were changed from 1.03 to 98.94 mg/l·h after oral or intravenous administration TPNS or Xuesaitong (TPNS) injection. The absolute bioavailability of R1, Rg1, Rd, Re and Rb1 were of 9.29%, 6.06%, 2.36%, 7.06% and 1.18%, respectively.
AB - LC/ESI/MS method was employed for the pharmacokinetic evaluation of total panax notoginsenoside (TPNS) in rats. After oral or intravenous administration of TPNS at the dosage of 300.0 or 10.0 mg kg-1 to rats respectively, panax notoginsenoside R1, ginsenoside Rg1, Rd, Re and Rb1 were simultaneous determined in rat plasma. Pharmacokinetic parameters and absolute bioavailability of panax notoginsenoside R1, ginsenoside Rg1, Rd, Re and Rb1 were obtained by the Drug And Statistics for windows (DAS) pharmacokinetic software. The pharmacokinetic parameters of all analytes were different form each other. T1/2 were changed from 0.72 to 22.16 h and AUC were changed from 1.03 to 98.94 mg/l·h after oral or intravenous administration TPNS or Xuesaitong (TPNS) injection. The absolute bioavailability of R1, Rg1, Rd, Re and Rb1 were of 9.29%, 6.06%, 2.36%, 7.06% and 1.18%, respectively.
KW - Absolute bioavailability
KW - Assaying
KW - Pharmacokinetic
KW - Total panax notoginsenoside (TPNS)
KW - Traditional Chinese medicine (TCM)
UR - https://www.scopus.com/pages/publications/34248139570
U2 - 10.1248/bpb.30.847
DO - 10.1248/bpb.30.847
M3 - 文章
C2 - 17473424
AN - SCOPUS:34248139570
SN - 0918-6158
VL - 30
SP - 847
EP - 851
JO - Biological and Pharmaceutical Bulletin
JF - Biological and Pharmaceutical Bulletin
IS - 5
ER -