PEG-sheddable polyplex micelles as smart gene carriers based on MMP-cleavable peptide-linked block copolymers

Junjie Li; Zhishen Ge; Shiyong Liu

doi:10.1039/c3cc43576h

PEG-sheddable polyplex micelles as smart gene carriers based on MMP-cleavable peptide-linked block copolymers

Junjie Li
, Zhishen Ge
, Shiyong Liu

University of Science and Technology of China

科研成果: 期刊稿件 › 文章 › 同行评审

94 引用（Scopus）

摘要

A matrix metalloproteinase-cleavable peptide-linked block copolymer was fabricated and utilized to construct PEG-sheddable polyplex micelles as smart gene delivery vectors, which were demonstrated to exhibit higher cellular uptake, improved endosomal escape, and high-efficiency gene transfection in the presence of matrix metalloproteinase-2.

源语言	英语
页（从-至）	6974-6976
页数	3
期刊	Chemical Communications
卷	49
期	62
DOI	https://doi.org/10.1039/c3cc43576h
出版状态	已出版 - 9 7月 2013
已对外发布	是

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abstract = "A matrix metalloproteinase-cleavable peptide-linked block copolymer was fabricated and utilized to construct PEG-sheddable polyplex micelles as smart gene delivery vectors, which were demonstrated to exhibit higher cellular uptake, improved endosomal escape, and high-efficiency gene transfection in the presence of matrix metalloproteinase-2.",

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T1 - PEG-sheddable polyplex micelles as smart gene carriers based on MMP-cleavable peptide-linked block copolymers

AU - Li, Junjie

AU - Ge, Zhishen

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N2 - A matrix metalloproteinase-cleavable peptide-linked block copolymer was fabricated and utilized to construct PEG-sheddable polyplex micelles as smart gene delivery vectors, which were demonstrated to exhibit higher cellular uptake, improved endosomal escape, and high-efficiency gene transfection in the presence of matrix metalloproteinase-2.

AB - A matrix metalloproteinase-cleavable peptide-linked block copolymer was fabricated and utilized to construct PEG-sheddable polyplex micelles as smart gene delivery vectors, which were demonstrated to exhibit higher cellular uptake, improved endosomal escape, and high-efficiency gene transfection in the presence of matrix metalloproteinase-2.

UR - https://www.scopus.com/pages/publications/84882242200

U2 - 10.1039/c3cc43576h

DO - 10.1039/c3cc43576h

M3 - 文章

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AN - SCOPUS:84882242200

SN - 1359-7345

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JO - Chemical Communications

JF - Chemical Communications

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ER -

PEG-sheddable polyplex micelles as smart gene carriers based on MMP-cleavable peptide-linked block copolymers

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