Palladium-Catalyzed Regio- and Enantioselective Synthesis of Allylic Amines Featuring Tetrasubstituted Tertiary Carbons

Aijie Cai; Wusheng Guo; Luis Martínez-Rodríguez; Arjan W. Kleij

doi:10.1021/jacs.6b08841

Palladium-Catalyzed Regio- and Enantioselective Synthesis of Allylic Amines Featuring Tetrasubstituted Tertiary Carbons

Aijie Cai
, Wusheng Guo
, Luis Martínez-Rodríguez
, Arjan W. Kleij

The Barcelona Institute of Science and Technology
ICREA

科研成果: 期刊稿件 › 文章 › 同行评审

186 引用（Scopus）

摘要

The first asymmetric synthesis of α,α-disubstituted allylic N-arylamines based on a palladium-catalyzed allylic amination has been developed. The protocol uses highly modular vinyl cyclic carbonates and unactivated aromatic amine nucleophiles as substrates. The catalytic process features minimal waste production, ample scope in reaction partners, high asymmetric induction up to 97% ee, and operational simplicity.

源语言	英语
页（从-至）	14194-14197
页数	4
期刊	Journal of the American Chemical Society
卷	138
期	43
DOI	https://doi.org/10.1021/jacs.6b08841
出版状态	已出版 - 2 11月 2016
已对外发布	是

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AU - Kleij, Arjan W.

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Palladium-Catalyzed Regio- and Enantioselective Synthesis of Allylic Amines Featuring Tetrasubstituted Tertiary Carbons

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