Palladium-catalyzed alkylarylation of acrylamides with unactivated alkyl halides

Hua Wang; Li Na Guo; Xin Hua Duan

doi:10.1021/acs.joc.5b02433

Palladium-catalyzed alkylarylation of acrylamides with unactivated alkyl halides

Hua Wang
, Li Na Guo
, Xin Hua Duan

化学学院

Xi'an Jiaotong University

科研成果: 期刊稿件 › 文章 › 同行评审

57 引用（Scopus）

摘要

An efficient palladium-catalyzed alkylarylation of acrylamides with unactivated alkyl halides has been developed. This method is highlighted by its broad substrate scope and excellent functional group tolerance. In addition to alkyl halides, fluoroalkyl halides and benzyl bromides also participated well in this transformation. A detailed mechanistic investigation suggests that a radical pathway is probably involved in the cyclization process.

源语言	英语
页（从-至）	860-867
页数	8
期刊	Journal of Organic Chemistry
卷	81
期	3
DOI	https://doi.org/10.1021/acs.joc.5b02433
出版状态	已出版 - 5 2月 2016

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10.1021/acs.joc.5b02433

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abstract = "An efficient palladium-catalyzed alkylarylation of acrylamides with unactivated alkyl halides has been developed. This method is highlighted by its broad substrate scope and excellent functional group tolerance. In addition to alkyl halides, fluoroalkyl halides and benzyl bromides also participated well in this transformation. A detailed mechanistic investigation suggests that a radical pathway is probably involved in the cyclization process.",

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AU - Wang, Hua

AU - Guo, Li Na

AU - Duan, Xin Hua

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Y1 - 2016/2/5

N2 - An efficient palladium-catalyzed alkylarylation of acrylamides with unactivated alkyl halides has been developed. This method is highlighted by its broad substrate scope and excellent functional group tolerance. In addition to alkyl halides, fluoroalkyl halides and benzyl bromides also participated well in this transformation. A detailed mechanistic investigation suggests that a radical pathway is probably involved in the cyclization process.

AB - An efficient palladium-catalyzed alkylarylation of acrylamides with unactivated alkyl halides has been developed. This method is highlighted by its broad substrate scope and excellent functional group tolerance. In addition to alkyl halides, fluoroalkyl halides and benzyl bromides also participated well in this transformation. A detailed mechanistic investigation suggests that a radical pathway is probably involved in the cyclization process.

UR - https://www.scopus.com/pages/publications/84957571498

U2 - 10.1021/acs.joc.5b02433

DO - 10.1021/acs.joc.5b02433

M3 - 文章

AN - SCOPUS:84957571498

SN - 0022-3263

VL - 81

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EP - 867

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

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Palladium-catalyzed alkylarylation of acrylamides with unactivated alkyl halides

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