Novel biodegradable pH/thermosensitive hydrogels: Part 1. Preparation and characterization

Kai Dong; Wei Xu; Cui Yu You; Jian Feng Xing; Ye Ji Zhang; Yang Gao; Ke Wang

doi:10.1080/00914037.2013.769233

Novel biodegradable pH/thermosensitive hydrogels: Part 1. Preparation and characterization

Kai Dong
, Wei Xu
, Cui Yu You
, Jian Feng Xing
, Ye Ji Zhang
, Yang Gao
, Ke Wang

医学部

Xi'an Jiaotong University

科研成果: 期刊稿件 › 文章 › 同行评审

9 引用（Scopus）

摘要

A series of biodegradable and pH/thermosensitive hydrogels based on monomethoxyl poly(ethylene glycol) (MPEG), poly(ε-caprolactone) (PCL), methylacrylic acid (MAA), and N-Isopropylacrylamide (NIPAAm) were prepared by UV-initiated free radical polymerization method. Swelling behavior and hydrolytic degradable behavior in aqueous medium with different pH values and pH/thermosensitivity of the hydrogels were studied in detail. The prepared biodegradable pH/thermo-sensitive hydrogels based on PCL, MPEG, MAA, and NIPAAm may have great potential application in smart drug delivery system.

源语言	英语
页（从-至）	726-732
页数	7
期刊	International Journal of Polymeric Materials and Polymeric Biomaterials
卷	62
期	14
DOI	https://doi.org/10.1080/00914037.2013.769233
出版状态	已出版 - 28 6月 2013

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abstract = "A series of biodegradable and pH/thermosensitive hydrogels based on monomethoxyl poly(ethylene glycol) (MPEG), poly(ε-caprolactone) (PCL), methylacrylic acid (MAA), and N-Isopropylacrylamide (NIPAAm) were prepared by UV-initiated free radical polymerization method. Swelling behavior and hydrolytic degradable behavior in aqueous medium with different pH values and pH/thermosensitivity of the hydrogels were studied in detail. The prepared biodegradable pH/thermo-sensitive hydrogels based on PCL, MPEG, MAA, and NIPAAm may have great potential application in smart drug delivery system.",

keywords = "Biodegradable, degradation, pH/thermosensitive, swelling/deswelling",

author = "Kai Dong and Wei Xu and You, \{Cui Yu\} and Xing, \{Jian Feng\} and Zhang, \{Ye Ji\} and Yang Gao and Ke Wang",

year = "2013",

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doi = "10.1080/00914037.2013.769233",

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T1 - Novel biodegradable pH/thermosensitive hydrogels

T2 - Part 1. Preparation and characterization

AU - Dong, Kai

AU - Xu, Wei

AU - You, Cui Yu

AU - Xing, Jian Feng

AU - Zhang, Ye Ji

AU - Gao, Yang

AU - Wang, Ke

PY - 2013/6/28

Y1 - 2013/6/28

N2 - A series of biodegradable and pH/thermosensitive hydrogels based on monomethoxyl poly(ethylene glycol) (MPEG), poly(ε-caprolactone) (PCL), methylacrylic acid (MAA), and N-Isopropylacrylamide (NIPAAm) were prepared by UV-initiated free radical polymerization method. Swelling behavior and hydrolytic degradable behavior in aqueous medium with different pH values and pH/thermosensitivity of the hydrogels were studied in detail. The prepared biodegradable pH/thermo-sensitive hydrogels based on PCL, MPEG, MAA, and NIPAAm may have great potential application in smart drug delivery system.

AB - A series of biodegradable and pH/thermosensitive hydrogels based on monomethoxyl poly(ethylene glycol) (MPEG), poly(ε-caprolactone) (PCL), methylacrylic acid (MAA), and N-Isopropylacrylamide (NIPAAm) were prepared by UV-initiated free radical polymerization method. Swelling behavior and hydrolytic degradable behavior in aqueous medium with different pH values and pH/thermosensitivity of the hydrogels were studied in detail. The prepared biodegradable pH/thermo-sensitive hydrogels based on PCL, MPEG, MAA, and NIPAAm may have great potential application in smart drug delivery system.

KW - Biodegradable

KW - degradation

KW - pH/thermosensitive

KW - swelling/deswelling

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M3 - 文章

AN - SCOPUS:84879678942

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JO - International Journal of Polymeric Materials and Polymeric Biomaterials

JF - International Journal of Polymeric Materials and Polymeric Biomaterials

IS - 14

ER -

Novel biodegradable pH/thermosensitive hydrogels: Part 1. Preparation and characterization

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