TY - JOUR
T1 - Mitochondria
T2 - New intracellular pharmacological target
AU - Long, Jian Gang
AU - Wang, Zhen Cheng
AU - Wang, Xue Min
PY - 2003/8/1
Y1 - 2003/8/1
N2 - Mitochondria not only acts a key role in energy generating process within the cell, but also is intimately associated with some important events in cells, such as apoptosis, generation of reactive oxygen species, lipid metabolism etc. For its special structure and function, mitochondria, as the pharmacological target for many agents, interacts with drugs extensively. Learning the interaction between mitochondria and drugs will greatly contribute to the understanding of the mechanism of the drugs, the design of new agents and the avoidance of the drug toxicity and side effect. This review is to present the related properties of mitochondria and its interactions with classical mitochondrial-targeted drugs.
AB - Mitochondria not only acts a key role in energy generating process within the cell, but also is intimately associated with some important events in cells, such as apoptosis, generation of reactive oxygen species, lipid metabolism etc. For its special structure and function, mitochondria, as the pharmacological target for many agents, interacts with drugs extensively. Learning the interaction between mitochondria and drugs will greatly contribute to the understanding of the mechanism of the drugs, the design of new agents and the avoidance of the drug toxicity and side effect. This review is to present the related properties of mitochondria and its interactions with classical mitochondrial-targeted drugs.
KW - Mitochondria
KW - Mitochondrial ATP-regulated potassium channel (mitoK)
KW - Permeability transition pore (PTP)
KW - Pharmacological target
KW - Reactive oxygen species (ROS)
UR - https://www.scopus.com/pages/publications/0141427824
M3 - 文章
AN - SCOPUS:0141427824
SN - 1001-1978
VL - 19
SP - 859
EP - 863
JO - Chinese Pharmacological Bulletin
JF - Chinese Pharmacological Bulletin
IS - 8
ER -