microRNA 基因多态性与血压钠钾反应性的相关性分析

Objective To investigate the relationship of miRNA gene polymorphisms with blood pressure (BP) responses to the sodium and potassium diet intervention. Methods In 2004, we recruited 514 participants from 124 families in seven villages of Baoji, Shaanxi Province, China. All subjects were given a three-day normal diet, followed by a seven-day low-salt diet, a seven-day high-salt diet, and finally a seven-day high-salt and potassium supplementation. A total of 19 miRNA single nucleotide polymorphisms (SNPs) were selected for analysis. Results Throughout the sodium-potassium dietary intervention, the BP of the subjects fluctuated across all phases, showing a decrease during the low-salt period and an increase during the high-salt period, followed by a reduction in BP subsequent to potassium supplementation during the high-salt diet. MiR-210-3p SNP nT2364149 was significantly associated with systolic BP (SBP), diastolic BP (DBP) and mean arterial pressure (MAP) responses to low-salt diet. MiR-i638-3p SNP ^6601178 was significantly associated with SBP while miR-26b-3p SNP ^115254818 was significantly associated with MAP responses to low-salt intervention. In addition, miR-26b-3p SNP rsll5254818 was significantly correlated with SBP, DBP and MAP responses to high-salt intervention. MiR-1307-5p SNPs rslll91676 and ri-2292807 were associated with SBP and MAP responses to high-salt diet. MiR-4638-3p SNP rs6601178, miR-210-3p SNP rsl2364149, miR- 382- 5p SNP rs4906032 and rs4143957 were significantly associated with SBP response to high-salt diet. In addition, miR-26b-3p SNP rsll5254818 was significantly associated with SBP, DBP and MAP responses to potassium supplementation. MiR-1307-Zp SNPs rslll91676, r?2292807, and miR-19a-3p SNP r.s4284505 were significantly associated with SBP responses to high-salt and potassium supplementation. Conclusion miRNA gene polymorphisms are associated with BP response to sodium and potassium, suggesting that miRNA genes may be involved in the pathophysiological process of salt sensitivity and potassium sensitivity.