Metal-free, visible-light driven C-H ketoalkylation of glycine derivatives and peptides

Hong Xin; Zi Hang Yuan; Mingyu Yang; Ming Hua Wang; Xin Hua Duan; Li Na Guo

doi:10.1039/d1gc03230e

Metal-free, visible-light driven C-H ketoalkylation of glycine derivatives and peptides

Hong Xin
, Zi Hang Yuan
, Mingyu Yang
, Ming Hua Wang
, Xin Hua Duan
, Li Na Guo

化学学院

Xi'an Jiaotong University
Lanzhou University

科研成果: 期刊稿件 › 文章 › 同行评审

48 引用（Scopus）

摘要

A metal-free, visible-light driven C-H ketoalkylation of glycine derivatives and peptides with cycloalkyl hydroperoxides is presented. This protocol provides a straightforward route to unnatural amino acids bearing a distal carbonyl group with moderate to good yields. Preliminary mechanistic studies revealed that both a SET event and radical chain propagation were involved in this transformation.

源语言	英语
页（从-至）	9549-9553
页数	5
期刊	Green Chemistry
卷	23
期	23
DOI	https://doi.org/10.1039/d1gc03230e
出版状态	已出版 - 7 12月 2021

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10.1039/d1gc03230e

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abstract = "A metal-free, visible-light driven C-H ketoalkylation of glycine derivatives and peptides with cycloalkyl hydroperoxides is presented. This protocol provides a straightforward route to unnatural amino acids bearing a distal carbonyl group with moderate to good yields. Preliminary mechanistic studies revealed that both a SET event and radical chain propagation were involved in this transformation.",

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AU - Xin, Hong

AU - Yuan, Zi Hang

AU - Yang, Mingyu

AU - Wang, Ming Hua

AU - Duan, Xin Hua

AU - Guo, Li Na

PY - 2021/12/7

Y1 - 2021/12/7

N2 - A metal-free, visible-light driven C-H ketoalkylation of glycine derivatives and peptides with cycloalkyl hydroperoxides is presented. This protocol provides a straightforward route to unnatural amino acids bearing a distal carbonyl group with moderate to good yields. Preliminary mechanistic studies revealed that both a SET event and radical chain propagation were involved in this transformation.

AB - A metal-free, visible-light driven C-H ketoalkylation of glycine derivatives and peptides with cycloalkyl hydroperoxides is presented. This protocol provides a straightforward route to unnatural amino acids bearing a distal carbonyl group with moderate to good yields. Preliminary mechanistic studies revealed that both a SET event and radical chain propagation were involved in this transformation.

UR - https://www.scopus.com/pages/publications/85120543520

U2 - 10.1039/d1gc03230e

DO - 10.1039/d1gc03230e

M3 - 文章

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SN - 1463-9262

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SP - 9549

EP - 9553

JO - Green Chemistry

JF - Green Chemistry

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Metal-free, visible-light driven C-H ketoalkylation of glycine derivatives and peptides

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