TY - JOUR
T1 - Long-term ambient air pollution and the risk of musculoskeletal diseases
T2 - A prospective cohort study
AU - Cheng, Bolun
AU - Pan, Chuyu
AU - Cai, Qingqing
AU - Liu, Li
AU - Cheng, Shiqiang
AU - Yang, Xuena
AU - Meng, Peilin
AU - Wei, Wenming
AU - He, Dan
AU - Liu, Huan
AU - Jia, Yumeng
AU - Wen, Yan
AU - Xu, Peng
AU - Zhang, Feng
N1 - Publisher Copyright:
© 2024 Elsevier B.V.
PY - 2024/3/15
Y1 - 2024/3/15
N2 - Evidence of the associations of air pollution and musculoskeletal diseases is inconsistent. This study aimed to examine the associations between air pollutants and the risk of incident musculoskeletal diseases, such as degenerative joint diseases (n = 38,850) and inflammatory arthropathies (n = 20,108). An air pollution score was constructed to assess the combined effect of PM2.5, PM2.5–10, NO2, and NOX. Cox proportional hazard model was applied to assess the relationships between air pollutants and the incidence of each musculoskeletal disease. The air pollution scores exhibited the modest association with an increased risk of osteoporosis (HR = 1.006, 95% CI: 1.002–1.011). Among the individual air pollutants, PM2.5 and PM2.5–10 exhibited the most significant effect on elevated risk of musculoskeletal diseases, such as PM2.5 on osteoporosis (HR = 1.064, 95% CI: 1.020–1.110), PM2.5–10 on inflammatory arthropathies (HR = 1.059, 95% CI: 1.037–1.081). Females were found to have a higher risk of incident musculoskeletal diseases when exposed to air pollutants. Individuals with extreme BMI or lower socioeconomic status had a higher risk of developing musculoskeletal diseases. Our findings reveal that long-term exposure to ambient air pollutants may contribute to an increased risk of musculoskeletal diseases.
AB - Evidence of the associations of air pollution and musculoskeletal diseases is inconsistent. This study aimed to examine the associations between air pollutants and the risk of incident musculoskeletal diseases, such as degenerative joint diseases (n = 38,850) and inflammatory arthropathies (n = 20,108). An air pollution score was constructed to assess the combined effect of PM2.5, PM2.5–10, NO2, and NOX. Cox proportional hazard model was applied to assess the relationships between air pollutants and the incidence of each musculoskeletal disease. The air pollution scores exhibited the modest association with an increased risk of osteoporosis (HR = 1.006, 95% CI: 1.002–1.011). Among the individual air pollutants, PM2.5 and PM2.5–10 exhibited the most significant effect on elevated risk of musculoskeletal diseases, such as PM2.5 on osteoporosis (HR = 1.064, 95% CI: 1.020–1.110), PM2.5–10 on inflammatory arthropathies (HR = 1.059, 95% CI: 1.037–1.081). Females were found to have a higher risk of incident musculoskeletal diseases when exposed to air pollutants. Individuals with extreme BMI or lower socioeconomic status had a higher risk of developing musculoskeletal diseases. Our findings reveal that long-term exposure to ambient air pollutants may contribute to an increased risk of musculoskeletal diseases.
KW - Air pollution
KW - Musculoskeletal diseases
KW - Prospective cohort
KW - Socioeconomic status
UR - https://www.scopus.com/pages/publications/85183966632
U2 - 10.1016/j.jhazmat.2024.133658
DO - 10.1016/j.jhazmat.2024.133658
M3 - 文章
C2 - 38310839
AN - SCOPUS:85183966632
SN - 0304-3894
VL - 466
JO - Journal of Hazardous Materials
JF - Journal of Hazardous Materials
M1 - 133658
ER -