TY - JOUR
T1 - Live birth sex ratio after in Vitro fertilization and embryo transfer in China - An analysis of 121,247 babies from 18 centers e113522
AU - Bu, Zhiqin
AU - Chen, Zi Jiang
AU - Huang, Guoning
AU - Zhang, Hanwang
AU - Wu, Qiongfang
AU - Yanping, Ma
AU - Shi, Juanzi
AU - Xu, Yanwen
AU - Zhang, Songying
AU - Zhang, Cuilian
AU - Zhao, Xiaoming
AU - Bo Zhang, Yuanhua Huang
AU - Sun, Zhengyi
AU - Kang, Yuefan
AU - Wu, Riran
AU - Wu, Xueqing
AU - Sun, Haixiang
AU - Sun, Yingpu
N1 - Publisher Copyright:
© 2014 Bu et al. This.
PY - 2014/11/20
Y1 - 2014/11/20
N2 - In order to study the impact of procedures of IVF/ICSI technology on sex ratio in China, we conducted this multi-center retrospective study including 121,247 babies born to 93,895 women in China. There were 62,700 male babies and 58,477 female babies, making the sex ratio being 51.8% (Male: Female = 107:100). In univariate logistic regression analysis, sex ratio was imbalance toward females of 50.3% when ICSI was preformed compared to 47.7% when IVF was used ( P<0.01). The sex ratio in IVF/ICSI babies was significantly higher toward males in transfers of blastocyst (54.9%) and thawed embryo (52.4%) when compared with transfers of cleavage stage embryo (51.4%) and fresh embryo (51.5%), respectively. Multiple delivery was not associated with sex ratio. However, in multivariable logistic regression analysis after controlling for related factors, only ICSI (adjusted OR = 0.90, 95%CI: 0.88-0.93; P<0.01) and blastocyst transfer (adjusted OR = 1.14, 95% CI: 1.09-1.20; P< 0.01) were associated with sex ratio in IVF/ICSI babies. In conclusion, the live birth sex ratio in IVF/ICSI babies was influenced by the use of ICSI, which may decrease the percentage of male offspring, or the use of blastocyst transfer, which may increase the percentage of male offspring.
AB - In order to study the impact of procedures of IVF/ICSI technology on sex ratio in China, we conducted this multi-center retrospective study including 121,247 babies born to 93,895 women in China. There were 62,700 male babies and 58,477 female babies, making the sex ratio being 51.8% (Male: Female = 107:100). In univariate logistic regression analysis, sex ratio was imbalance toward females of 50.3% when ICSI was preformed compared to 47.7% when IVF was used ( P<0.01). The sex ratio in IVF/ICSI babies was significantly higher toward males in transfers of blastocyst (54.9%) and thawed embryo (52.4%) when compared with transfers of cleavage stage embryo (51.4%) and fresh embryo (51.5%), respectively. Multiple delivery was not associated with sex ratio. However, in multivariable logistic regression analysis after controlling for related factors, only ICSI (adjusted OR = 0.90, 95%CI: 0.88-0.93; P<0.01) and blastocyst transfer (adjusted OR = 1.14, 95% CI: 1.09-1.20; P< 0.01) were associated with sex ratio in IVF/ICSI babies. In conclusion, the live birth sex ratio in IVF/ICSI babies was influenced by the use of ICSI, which may decrease the percentage of male offspring, or the use of blastocyst transfer, which may increase the percentage of male offspring.
UR - https://www.scopus.com/pages/publications/84912139552
U2 - 10.1371/journal.pone.0113522
DO - 10.1371/journal.pone.0113522
M3 - 文章
C2 - 25412419
AN - SCOPUS:84912139552
SN - 1932-6203
VL - 9
JO - PLoS ONE
JF - PLoS ONE
IS - 11
M1 - e113522
ER -