Investigation on NB4 cell responses to realgar by cDNA microarray

Huai Yu Wang; Shan Xi Liu

Investigation on NB4 cell responses to realgar by cDNA microarray

Huai Yu Wang
, Shan Xi Liu

The First Affiliated Hospital of Xi’an Jiaotong University

科研成果: 期刊稿件 › 文章 › 同行评审

5 引用（Scopus）

摘要

Objective: To elucidate the molecular mechanism of realgar-induced apoptosis and differentiation of acute promyelocytic leukemia(APL) cell line NB4. Method: The response of NB4 cells to realgar was explored with a cDNA microarray representing 1003 different human genes. Result: The analysis of gene expression profiles indicated that 9 genes were up-regulated and 37 genes were down-regulated. Among the 9 up-regulated genes, 2 genes were involved in proteasome degradation pathway. Conclusion: PSMC2, PSMD1 and ITGB1 genes may play a role in the apoptosis and differentiation of NB4 cells.

源语言	英语
页（从-至）	603-604
页数	2
期刊	Zhongguo Zhongyao Zazhi
卷	27
期	8
出版状态	已出版 - 8月 2002
已对外发布	是

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title = "Investigation on NB4 cell responses to realgar by cDNA microarray",

abstract = "Objective: To elucidate the molecular mechanism of realgar-induced apoptosis and differentiation of acute promyelocytic leukemia(APL) cell line NB4. Method: The response of NB4 cells to realgar was explored with a cDNA microarray representing 1003 different human genes. Result: The analysis of gene expression profiles indicated that 9 genes were up-regulated and 37 genes were down-regulated. Among the 9 up-regulated genes, 2 genes were involved in proteasome degradation pathway. Conclusion: PSMC2, PSMD1 and ITGB1 genes may play a role in the apoptosis and differentiation of NB4 cells.",

keywords = "Acute, DNA microarray, Leukemia, Promyelocytic, Realgar",

author = "Wang, \{Huai Yu\} and Liu, \{Shan Xi\}",

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T1 - Investigation on NB4 cell responses to realgar by cDNA microarray

AU - Wang, Huai Yu

AU - Liu, Shan Xi

PY - 2002/8

Y1 - 2002/8

N2 - Objective: To elucidate the molecular mechanism of realgar-induced apoptosis and differentiation of acute promyelocytic leukemia(APL) cell line NB4. Method: The response of NB4 cells to realgar was explored with a cDNA microarray representing 1003 different human genes. Result: The analysis of gene expression profiles indicated that 9 genes were up-regulated and 37 genes were down-regulated. Among the 9 up-regulated genes, 2 genes were involved in proteasome degradation pathway. Conclusion: PSMC2, PSMD1 and ITGB1 genes may play a role in the apoptosis and differentiation of NB4 cells.

AB - Objective: To elucidate the molecular mechanism of realgar-induced apoptosis and differentiation of acute promyelocytic leukemia(APL) cell line NB4. Method: The response of NB4 cells to realgar was explored with a cDNA microarray representing 1003 different human genes. Result: The analysis of gene expression profiles indicated that 9 genes were up-regulated and 37 genes were down-regulated. Among the 9 up-regulated genes, 2 genes were involved in proteasome degradation pathway. Conclusion: PSMC2, PSMD1 and ITGB1 genes may play a role in the apoptosis and differentiation of NB4 cells.

KW - Acute

KW - DNA microarray

KW - Leukemia

KW - Promyelocytic

KW - Realgar

UR - https://www.scopus.com/pages/publications/0346451030

M3 - 文章

C2 - 12776498

AN - SCOPUS:0346451030

SN - 1001-5302

VL - 27

SP - 603

EP - 604

JO - Zhongguo Zhongyao Zazhi

JF - Zhongguo Zhongyao Zazhi

IS - 8

ER -

Investigation on NB4 cell responses to realgar by cDNA microarray

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