Investigation of the metabolism of 7-(4-(chlorbenzyl)7,8,13,13a-tetrahydroberberine chloride in the rat

N. Feng; Zhengxing Zhang; D. An; W. Huang; G. Wang; X. Han; X. Bao

doi:10.1007/BF03189825

Investigation of the metabolism of 7-(4-(chlorbenzyl)7,8,13,13a-tetrahydroberberine chloride in the rat

N. Feng
, Zhengxing Zhang
, D. An
, W. Huang
, G. Wang
, X. Han
, X. Bao

China Pharmaceutical University
CAS - Dalian Institute of Chemical Physics

科研成果: 期刊稿件 › 文章 › 同行评审

5 引用（Scopus）

摘要

The metabolism of 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride (CTHB), a compound with promising pharmacological effects against arrhythmia, was investigated in rat bile. A metabolite and unchanged CTHB were found in the bile. Characterization and structural elucidation of the metabolite was achieved by LC/MS and LC/NMR. The following metabolic pathway is proposed: CTHB is metabolized by demethylation at position 10 to produce a new entity.

源语言	英语
页（从-至）	41-44
页数	4
期刊	European Journal of Drug Metabolism and Pharmacokinetics
卷	23
期	1
DOI	https://doi.org/10.1007/BF03189825
出版状态	已出版 - 1998
已对外发布	是

访问文件

10.1007/BF03189825

其它文件与链接

链接到 Scopus 的出版物

引用此

@article{5ea934e45b42454993de11fb7e3ea183,

title = "Investigation of the metabolism of 7-(4-(chlorbenzyl)7,8,13,13a-tetrahydroberberine chloride in the rat",

abstract = "The metabolism of 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride (CTHB), a compound with promising pharmacological effects against arrhythmia, was investigated in rat bile. A metabolite and unchanged CTHB were found in the bile. Characterization and structural elucidation of the metabolite was achieved by LC/MS and LC/NMR. The following metabolic pathway is proposed: CTHB is metabolized by demethylation at position 10 to produce a new entity.",

keywords = "7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride, LC/MS, LC/NMR, Metabolism, Rat",

author = "N. Feng and Zhengxing Zhang and D. An and W. Huang and G. Wang and X. Han and X. Bao",

year = "1998",

doi = "10.1007/BF03189825",

language = "英语",

volume = "23",

pages = "41--44",

journal = "European Journal of Drug Metabolism and Pharmacokinetics",

issn = "0378-7966",

publisher = "Adis",

number = "1",

}

TY - JOUR

T1 - Investigation of the metabolism of 7-(4-(chlorbenzyl)7,8,13,13a-tetrahydroberberine chloride in the rat

AU - Feng, N.

AU - Zhang, Zhengxing

AU - An, D.

AU - Huang, W.

AU - Wang, G.

AU - Han, X.

AU - Bao, X.

PY - 1998

Y1 - 1998

N2 - The metabolism of 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride (CTHB), a compound with promising pharmacological effects against arrhythmia, was investigated in rat bile. A metabolite and unchanged CTHB were found in the bile. Characterization and structural elucidation of the metabolite was achieved by LC/MS and LC/NMR. The following metabolic pathway is proposed: CTHB is metabolized by demethylation at position 10 to produce a new entity.

AB - The metabolism of 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride (CTHB), a compound with promising pharmacological effects against arrhythmia, was investigated in rat bile. A metabolite and unchanged CTHB were found in the bile. Characterization and structural elucidation of the metabolite was achieved by LC/MS and LC/NMR. The following metabolic pathway is proposed: CTHB is metabolized by demethylation at position 10 to produce a new entity.

KW - 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride

KW - LC/MS

KW - LC/NMR

KW - Metabolism

KW - Rat

UR - https://www.scopus.com/pages/publications/0031961558

U2 - 10.1007/BF03189825

DO - 10.1007/BF03189825

M3 - 文章

AN - SCOPUS:0031961558

SN - 0378-7966

VL - 23

SP - 41

EP - 44

JO - European Journal of Drug Metabolism and Pharmacokinetics

JF - European Journal of Drug Metabolism and Pharmacokinetics

IS - 1

ER -

Investigation of the metabolism of 7-(4-(chlorbenzyl)7,8,13,13a-tetrahydroberberine chloride in the rat

摘要

访问文件

其它文件与链接

学术指纹

引用此