H2O2-driven enzymatic oxyfunctionalization of tertiary C-H bonds

Yawen Huang; Huanhuan Li; Pengpeng Zhang; Yalan Zhang; Peigao Duan; Wuyuan Zhang

doi:10.1039/d3cc02925e

H₂O₂-driven enzymatic oxyfunctionalization of tertiary C-H bonds

Yawen Huang
, Huanhuan Li
, Pengpeng Zhang
, Yalan Zhang
, Peigao Duan
, Wuyuan Zhang

化学工程与技术学院

University of Chinese Academy of Sciences
CAS - Tianjin Institute of Industrial Biotechnology
Xi'an Jiaotong University
National Technology Innovation Center of Synthetic Biology

科研成果: 期刊稿件 › 文章 › 同行评审

6 引用（Scopus）

摘要

Peroxygenase from Agrocybe aegerita catalyses the selective hydroxylation of tertiary C-H bonds, whereby tertiary alcohols, diols, ketols, etc., were obtained in good to high regioselectivity and turnover numbers. This method can also be expanded for late-stage functionalization of drug molecules, which represents a streamlined synthetic method to give access to useful compounds.

源语言	英语
页（从-至）	9219-9222
页数	4
期刊	Chemical Communications
卷	59
期	60
DOI	https://doi.org/10.1039/d3cc02925e
出版状态	已出版 - 3 7月 2023

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10.1039/d3cc02925e

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abstract = "Peroxygenase from Agrocybe aegerita catalyses the selective hydroxylation of tertiary C-H bonds, whereby tertiary alcohols, diols, ketols, etc., were obtained in good to high regioselectivity and turnover numbers. This method can also be expanded for late-stage functionalization of drug molecules, which represents a streamlined synthetic method to give access to useful compounds.",

author = "Yawen Huang and Huanhuan Li and Pengpeng Zhang and Yalan Zhang and Peigao Duan and Wuyuan Zhang",

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AU - Huang, Yawen

AU - Li, Huanhuan

AU - Zhang, Pengpeng

AU - Zhang, Yalan

AU - Duan, Peigao

AU - Zhang, Wuyuan

PY - 2023/7/3

Y1 - 2023/7/3

N2 - Peroxygenase from Agrocybe aegerita catalyses the selective hydroxylation of tertiary C-H bonds, whereby tertiary alcohols, diols, ketols, etc., were obtained in good to high regioselectivity and turnover numbers. This method can also be expanded for late-stage functionalization of drug molecules, which represents a streamlined synthetic method to give access to useful compounds.

AB - Peroxygenase from Agrocybe aegerita catalyses the selective hydroxylation of tertiary C-H bonds, whereby tertiary alcohols, diols, ketols, etc., were obtained in good to high regioselectivity and turnover numbers. This method can also be expanded for late-stage functionalization of drug molecules, which represents a streamlined synthetic method to give access to useful compounds.

UR - https://www.scopus.com/pages/publications/85165430502

U2 - 10.1039/d3cc02925e

DO - 10.1039/d3cc02925e

M3 - 文章

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AN - SCOPUS:85165430502

SN - 1359-7345

VL - 59

SP - 9219

EP - 9222

JO - Chemical Communications

JF - Chemical Communications

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ER -

H2O2-driven enzymatic oxyfunctionalization of tertiary C-H bonds

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H₂O₂-driven enzymatic oxyfunctionalization of tertiary C-H bonds