Expert consensus on the detection and clinical application of tumor mutational burden

Zhenying Guo; Chunwei Xu; Shirong Zhang; Yue Hao; Xiaotong Hu; Ming Zhao; Chan Xiang; Yingshi Piao; Pingli Sun; Xueping Xiang; Jing Zhao; Huanwen Wu; Weixing Li; Jinpu Yu; Jingping Yuan; Shuangshuang Wang; Cong Wang; Yun Gu; Bingjian Lv; Liping Zhang; Yueping Liu; Xiaobin Cui; Weizhong Gu; Yining Li; Wei Wang; Wenjun Yang; Weiguo Long; Jingjing Xiang; Hong Mou; Biao Liu; Huajuan Ruan; Yubin Wang; Yongjie Zhu; Feng Wang; Zhonghua Wang; Xiaomin Feng; Xing Liu; Peng Li; Min Deng; Bin Lian; Lili Mao; Qian Wang; Wenxian Wang; Zhengbo Song; Ziming Li; Wenzhao Zhong; Zhijie Wang; Shengxiang Ren; Wenfeng Fang; Yongchang Zhang; Jingjing Liu; Xiuyu Cai; Anwen Liu; Wen Li; Ping Zhan; Hongbing Liu; Tangfeng Lv; Liyun Miao; Lingfeng Min; Yu Chen; Yu Zhang; Feng Wang; Zhansheng Jiang; Gen Lin; Long Huang; Xingxiang Pu; Rongbo Lin; Weifeng Liu; Chuangzhou Rao; Dongqing Lv; Zongyang Yu; Peng Shen; Xiaoyan Li; Chuanhao Tang; Chengzhi Zhou; Junping Zhang; Junli Xue; Hui Guo; Qian Chu; Rui Meng; Jingxun Wu; Rui Zhang; Jin Zhou; Zhengfei Zhu; Yongheng Li; Hong Qiu; Fan Xia; Yuanyuan Lu; Xiaofeng Chen; Rui Ge; Enyong Dai; Yu Han; Jian Zhang; Yinghua Ji; Xianbin Liang; Hongmei Zhang; Xuelei Ma; Xuewen Liu; Yu Yao; Peng Luo; Weiwei Pan; Fei Pang; Fan Wu; Dejian Gu; Li Wang; Liping Wang; Youcai Zhu; Li Lin; Weiwen Li; Xinqing Lin; Jing Cai; Ling Xu; Jisheng Li; Xiaodong Jiao; Kainan Li; Jia Wei; Huijing Feng; Lin Wang; Yingying Du; Wang Yao; Xuefei Shi; Xiaomin Niu; Dongmei Yuan; Yanwen Yao; Yinbin Zhang; Binbin Song; Wenfeng Li; Jianfei Fu; Hong Wang; Mingxiang Ye; Dong Wang; Zhaofeng Wang; Qing Ji; Yuan Fang; Qing Wei; Zhen Wang; Bin Wan; Donglai Lv; Xiaofeng Li; Shengjie Yang; Jing Kang; Jiatao Zhang; Chao Zhang; Lin Shi; Yina Wang; Bihui Li; Zhang Zhang; Ke Wang; Zhefeng Liu; Nong Yang; Lin Wu; Xiaobing Chen; Gu Jin; Zhongwu Li; Miao Li; Guansong Wang; Jiandong Wang; Meiyu Fang; Yong Fang; Xiaojia Wang; Jing Chen; Yiping Zhang; Xixu Zhu; Yi Shen; Shenglin Ma; Biyun Wang; Lu Si; Yong Song; Yuanzhi Lu; Aijun Liu; Yuchen Han

doi:10.20892/j.issn.2095-3941.2025.0351

Expert consensus on the detection and clinical application of tumor mutational burden

Zhenying Guo
, Chunwei Xu
, Shirong Zhang
, Yue Hao
, Xiaotong Hu
, Ming Zhao
, Chan Xiang
, Yingshi Piao
, Pingli Sun
, Xueping Xiang
, Jing Zhao
, Huanwen Wu
, Weixing Li
, Jinpu Yu
, Jingping Yuan
, Shuangshuang Wang
, Cong Wang
, Yun Gu
, Bingjian Lv
, Liping Zhang

Yueping Liu, Xiaobin Cui, Weizhong Gu, Yining Li, Wei Wang, Wenjun Yang, Weiguo Long, Jingjing Xiang, Hong Mou, Biao Liu, Huajuan Ruan, Yubin Wang, Yongjie Zhu, Feng Wang, Zhonghua Wang, Xiaomin Feng, Xing Liu, Peng Li, Min Deng, Bin Lian, Lili Mao, Qian Wang, Wenxian Wang, Zhengbo Song, Ziming Li, Wenzhao Zhong, Zhijie Wang, Shengxiang Ren, Wenfeng Fang, Yongchang Zhang, Jingjing Liu, Xiuyu Cai, Anwen Liu, Wen Li, Ping Zhan, Hongbing Liu, Tangfeng Lv, Liyun Miao, Lingfeng Min, Yu Chen, Yu Zhang, Feng Wang, Zhansheng Jiang, Gen Lin, Long Huang, Xingxiang Pu, Rongbo Lin, Weifeng Liu, Chuangzhou Rao, Dongqing Lv, Zongyang Yu, Peng Shen, Xiaoyan Li, Chuanhao Tang, Chengzhi Zhou, Junping Zhang, Junli Xue, Hui Guo, Qian Chu, Rui Meng, Jingxun Wu, Rui Zhang, Jin Zhou, Zhengfei Zhu, Yongheng Li, Hong Qiu, Fan Xia, Yuanyuan Lu, Xiaofeng Chen, Rui Ge, Enyong Dai, Yu Han, Jian Zhang, Yinghua Ji, Xianbin Liang, Hongmei Zhang, Xuelei Ma, Xuewen Liu, Yu Yao, Peng Luo, Weiwei Pan, Fei Pang, Fan Wu, Dejian Gu, Li Wang, Liping Wang, Youcai Zhu, Li Lin, Weiwen Li, Xinqing Lin, Jing Cai, Ling Xu, Jisheng Li, Xiaodong Jiao, Kainan Li, Jia Wei, Huijing Feng, Lin Wang, Yingying Du, Wang Yao, Xuefei Shi, Xiaomin Niu, Dongmei Yuan, Yanwen Yao, Yinbin Zhang, Binbin Song, Wenfeng Li, Jianfei Fu, Hong Wang, Mingxiang Ye, Dong Wang, Zhaofeng Wang, Qing Ji, Yuan Fang, Qing Wei, Zhen Wang, Bin Wan, Donglai Lv, Xiaofeng Li, Shengjie Yang, Jing Kang, Jiatao Zhang, Chao Zhang, Lin Shi, Yina Wang, Bihui Li, Zhang Zhang, Ke Wang, Zhefeng Liu, Nong Yang, Lin Wu, Xiaobing Chen, Gu Jin, Zhongwu Li, Miao Li, Guansong Wang, Jiandong Wang, Meiyu Fang, Yong Fang, Xiaojia Wang, Jing Chen, Yiping Zhang, Xixu Zhu, Yi Shen, Shenglin Ma, Biyun Wang, Lu Si, Yong Song, Yuanzhi Lu, Aijun Liu, Yuchen Han

医学部

Zhejiang Provincial People's Hospital
Chinese Academy of Sciences
Westlake University
Zhejiang University
Ningbo Clinical Pathology Diagnosis Center
Shanghai Jiao Tong University
Capital Medical University
Jilin University
Chinese Academy of Medical Sciences
Tianjin Medical University
Renmin Hospital of Wuhan University
Affiliated Hospital of Nanjing University of Chinese Medicine
The First Affiliated Hospital with Nanjing Medical University
Women's Hospital of Nanjing Medical University
Fudan University
Hebei Medical University
Nanjing University
Children’s Hospital of Zhejiang University
Tongde Hospital of Zhejiang Province
The Affiliated Hospital of Hangzhou Normal University
People's Hospital of Leshan
Chun'an First People's Hospital
Nanjing Medical University
Hangzhou First People's Hospital
Tiantai County People's Hospital
First People's Hospital of Aksu Prefecture
Shulan (Hangzhou) Hospital
The First Affiliated Hospital of Wenzhou Medical University
Peking University
Guangdong Academy of Medical Sciences
Tongji University
Sun Yat-Sen University Cancer Center
Central South University
Jilin Cancer Hospital
Nanchang University
The Second Affiliated Hospital of Zhejiang University School of Medicine
Yangzhou University
Fujian Medical University
Guizhou Provincial People's Hospital
University of Chinese Academy of Sciences
Wenzhou Medical University
Nanfang Hospital
The First Affiliated Hospital of Guanzhou Medical University
Shanxi Bethune Hospital
Huazhong University of Science and Technology
Xiamen University
China Medical University
University of Electronic Science and Technology of China
Xijing Hospital
Huadong Hospital
Harbin Medical University
Southern Medical University
Xinxiang Medical College
The Third People's Hospital of Zhengzhou
Sichuan University
The First Affiliated Hospital of Xi’an Jiaotong University
Jiaxing University
Ltd
Menarini Silicon Biosystems SpA
Department of Medical
Baotou Cancer Hospital
Lishui Central Hospital
Anhui Chest Hospital
Shandong University
Naval Medical University
Anhui Medical University
Sun Yat-Sen University
Xi'an Jiaotong University
General Hospital of People's Liberation Army
Annhui Provincial Children's Hospital
The Affiliated Jiangning Hospital of Nanjing Medical University
The 901 Hospital of Joint Logistics Support Force of People Liberation Army
Chuxiong Yi Autonomous Prefecture People's Hospital
Guilin Medical College
Jinan University
Jiangsu Institute of Nuclear Medicine
Zhengzhou University
The Cancer Hospital of Qinghai Province
Army Medical University
The First Affiliated Hospital of Jinan University

科研成果: 期刊稿件 › 文章 › 同行评审

2 引用（Scopus）

摘要

As an emerging biomarker, tumor mutational burden (TMB) has attracted increasing attention from clinicians in predicting the efficacy of tumor immunotherapy. Currently, TMB is detected primarily by whole-exome sequencing or targeted panel sequencing on high-throughput sequencing platforms. However, the lack of uniformity in detection methods, threshold settings, and reporting formats, as well as the significant differences in TMB values among different cancer types, have hindered the standardized application of this biomarker in clinical practice. This consensus focuses on the definition, standardization of detection, clinical significance, and limitations of TMB, and provides consensus recommendations for the clinical application of TMB in real-world practice in China. This consensus is aimed at helping clinicians and laboratory personnel understand the clinical significance and testing standards of TMB, promoting more accurate interpretation of test results, and improving patient care.

源语言	英语
期刊	Cancer Biology and Medicine
卷	23
期	2
DOI	https://doi.org/10.20892/j.issn.2095-3941.2025.0351
出版状态	已出版 - 17 2月 2026

联合国可持续发展目标

此成果有助于实现下列可持续发展目标：

可持续发展目标 3 良好健康与福祉

访问文件

10.20892/j.issn.2095-3941.2025.0351

其它文件与链接

链接到 Scopus 的出版物

引用此

Guo, Z., Xu, C., Zhang, S., Hao, Y., Hu, X., Zhao, M., Xiang, C., Piao, Y., Sun, P., Xiang, X., Zhao, J., Wu, H., Li, W., Yu, J., Yuan, J., Wang, S., Wang, C., Gu, Y., Lv, B., ... Han, Y. (2026). Expert consensus on the detection and clinical application of tumor mutational burden. Cancer Biology and Medicine, 23(2). https://doi.org/10.20892/j.issn.2095-3941.2025.0351

@article{508359606c1f4141922b552a8cfa2cf0,

title = "Expert consensus on the detection and clinical application of tumor mutational burden",

abstract = "As an emerging biomarker, tumor mutational burden (TMB) has attracted increasing attention from clinicians in predicting the efficacy of tumor immunotherapy. Currently, TMB is detected primarily by whole-exome sequencing or targeted panel sequencing on high-throughput sequencing platforms. However, the lack of uniformity in detection methods, threshold settings, and reporting formats, as well as the significant differences in TMB values among different cancer types, have hindered the standardized application of this biomarker in clinical practice. This consensus focuses on the definition, standardization of detection, clinical significance, and limitations of TMB, and provides consensus recommendations for the clinical application of TMB in real-world practice in China. This consensus is aimed at helping clinicians and laboratory personnel understand the clinical significance and testing standards of TMB, promoting more accurate interpretation of test results, and improving patient care.",

keywords = "Biomarkers, targeted panel sequencing, tumor immunotherapy, tumor mutational burden, whole-exome sequencing",

author = "Zhenying Guo and Chunwei Xu and Shirong Zhang and Yue Hao and Xiaotong Hu and Ming Zhao and Chan Xiang and Yingshi Piao and Pingli Sun and Xueping Xiang and Jing Zhao and Huanwen Wu and Weixing Li and Jinpu Yu and Jingping Yuan and Shuangshuang Wang and Cong Wang and Yun Gu and Bingjian Lv and Liping Zhang and Yueping Liu and Xiaobin Cui and Weizhong Gu and Yining Li and Wei Wang and Wenjun Yang and Weiguo Long and Jingjing Xiang and Hong Mou and Biao Liu and Huajuan Ruan and Yubin Wang and Yongjie Zhu and Feng Wang and Zhonghua Wang and Xiaomin Feng and Xing Liu and Peng Li and Min Deng and Bin Lian and Lili Mao and Qian Wang and Wenxian Wang and Zhengbo Song and Ziming Li and Wenzhao Zhong and Zhijie Wang and Shengxiang Ren and Wenfeng Fang and Yongchang Zhang and Jingjing Liu and Xiuyu Cai and Anwen Liu and Wen Li and Ping Zhan and Hongbing Liu and Tangfeng Lv and Liyun Miao and Lingfeng Min and Yu Chen and Yu Zhang and Feng Wang and Zhansheng Jiang and Gen Lin and Long Huang and Xingxiang Pu and Rongbo Lin and Weifeng Liu and Chuangzhou Rao and Dongqing Lv and Zongyang Yu and Peng Shen and Xiaoyan Li and Chuanhao Tang and Chengzhi Zhou and Junping Zhang and Junli Xue and Hui Guo and Qian Chu and Rui Meng and Jingxun Wu and Rui Zhang and Jin Zhou and Zhengfei Zhu and Yongheng Li and Hong Qiu and Fan Xia and Yuanyuan Lu and Xiaofeng Chen and Rui Ge and Enyong Dai and Yu Han and Jian Zhang and Yinghua Ji and Xianbin Liang and Hongmei Zhang and Xuelei Ma and Xuewen Liu and Yu Yao and Peng Luo and Weiwei Pan and Fei Pang and Fan Wu and Dejian Gu and Li Wang and Liping Wang and Youcai Zhu and Li Lin and Weiwen Li and Xinqing Lin and Jing Cai and Ling Xu and Jisheng Li and Xiaodong Jiao and Kainan Li and Jia Wei and Huijing Feng and Lin Wang and Yingying Du and Wang Yao and Xuefei Shi and Xiaomin Niu and Dongmei Yuan and Yanwen Yao and Yinbin Zhang and Binbin Song and Wenfeng Li and Jianfei Fu and Hong Wang and Mingxiang Ye and Dong Wang and Zhaofeng Wang and Qing Ji and Yuan Fang and Qing Wei and Zhen Wang and Bin Wan and Donglai Lv and Xiaofeng Li and Shengjie Yang and Jing Kang and Jiatao Zhang and Chao Zhang and Lin Shi and Yina Wang and Bihui Li and Zhang Zhang and Ke Wang and Zhefeng Liu and Nong Yang and Lin Wu and Xiaobing Chen and Gu Jin and Zhongwu Li and Miao Li and Guansong Wang and Jiandong Wang and Meiyu Fang and Yong Fang and Xiaojia Wang and Jing Chen and Yiping Zhang and Xixu Zhu and Yi Shen and Shenglin Ma and Biyun Wang and Lu Si and Yong Song and Yuanzhi Lu and Aijun Liu and Yuchen Han",

note = "Publisher Copyright: Copyright {\textcopyright} 2026 The Authors.",

year = "2026",

month = feb,

day = "17",

doi = "10.20892/j.issn.2095-3941.2025.0351",

language = "英语",

volume = "23",

journal = "Cancer Biology and Medicine",

issn = "2095-3941",

publisher = "Cancer Biology and Medicine",

number = "2",

}

Guo, Z, Xu, C, Zhang, S, Hao, Y, Hu, X, Zhao, M, Xiang, C, Piao, Y, Sun, P, Xiang, X, Zhao, J, Wu, H, Li, W, Yu, J, Yuan, J, Wang, S, Wang, C, Gu, Y, Lv, B, Zhang, L, Liu, Y, Cui, X, Gu, W, Li, Y, Wang, W, Yang, W, Long, W, Xiang, J, Mou, H, Liu, B, Ruan, H, Wang, Y, Zhu, Y, Wang, F, Wang, Z, Feng, X, Liu, X, Li, P, Deng, M, Lian, B, Mao, L, Wang, Q, Wang, W, Song, Z, Li, Z, Zhong, W, Wang, Z, Ren, S, Fang, W, Zhang, Y, Liu, J, Cai, X, Liu, A, Li, W, Zhan, P, Liu, H, Lv, T, Miao, L, Min, L, Chen, Y, Zhang, Y, Wang, F, Jiang, Z, Lin, G, Huang, L, Pu, X, Lin, R, Liu, W, Rao, C, Lv, D, Yu, Z, Shen, P, Li, X, Tang, C, Zhou, C, Zhang, J, Xue, J, Guo, H, Chu, Q, Meng, R, Wu, J, Zhang, R, Zhou, J, Zhu, Z, Li, Y, Qiu, H, Xia, F, Lu, Y, Chen, X, Ge, R, Dai, E, Han, Y, Zhang, J, Ji, Y, Liang, X, Zhang, H, Ma, X, Liu, X, Yao, Y, Luo, P, Pan, W, Pang, F, Wu, F, Gu, D, Wang, L, Wang, L, Zhu, Y, Lin, L, Li, W, Lin, X, Cai, J, Xu, L, Li, J, Jiao, X, Li, K, Wei, J, Feng, H, Wang, L, Du, Y, Yao, W, Shi, X, Niu, X, Yuan, D, Yao, Y, Zhang, Y, Song, B, Li, W, Fu, J, Wang, H, Ye, M, Wang, D, Wang, Z, Ji, Q, Fang, Y, Wei, Q, Wang, Z, Wan, B, Lv, D, Li, X, Yang, S, Kang, J, Zhang, J, Zhang, C, Shi, L, Wang, Y, Li, B, Zhang, Z, Wang, K, Liu, Z, Yang, N, Wu, L, Chen, X, Jin, G, Li, Z, Li, M, Wang, G, Wang, J, Fang, M, Fang, Y, Wang, X, Chen, J, Zhang, Y, Zhu, X, Shen, Y, Ma, S, Wang, B, Si, L, Song, Y, Lu, Y, Liu, A & Han, Y 2026, 'Expert consensus on the detection and clinical application of tumor mutational burden', Cancer Biology and Medicine, 卷 23, 号码 2. https://doi.org/10.20892/j.issn.2095-3941.2025.0351

TY - JOUR

T1 - Expert consensus on the detection and clinical application of tumor mutational burden

AU - Guo, Zhenying

AU - Xu, Chunwei

AU - Zhang, Shirong

AU - Hao, Yue

AU - Hu, Xiaotong

AU - Zhao, Ming

AU - Xiang, Chan

AU - Piao, Yingshi

AU - Sun, Pingli

AU - Xiang, Xueping

AU - Zhao, Jing

AU - Wu, Huanwen

AU - Li, Weixing

AU - Yu, Jinpu

AU - Yuan, Jingping

AU - Wang, Shuangshuang

AU - Wang, Cong

AU - Gu, Yun

AU - Lv, Bingjian

AU - Zhang, Liping

AU - Liu, Yueping

AU - Cui, Xiaobin

AU - Gu, Weizhong

AU - Li, Yining

AU - Wang, Wei

AU - Yang, Wenjun

AU - Long, Weiguo

AU - Xiang, Jingjing

AU - Mou, Hong

AU - Liu, Biao

AU - Ruan, Huajuan

AU - Wang, Yubin

AU - Zhu, Yongjie

AU - Wang, Feng

AU - Wang, Zhonghua

AU - Feng, Xiaomin

AU - Liu, Xing

AU - Li, Peng

AU - Deng, Min

AU - Lian, Bin

AU - Mao, Lili

AU - Wang, Qian

AU - Wang, Wenxian

AU - Song, Zhengbo

AU - Li, Ziming

AU - Zhong, Wenzhao

AU - Wang, Zhijie

AU - Ren, Shengxiang

AU - Fang, Wenfeng

AU - Zhang, Yongchang

AU - Liu, Jingjing

AU - Cai, Xiuyu

AU - Liu, Anwen

AU - Li, Wen

AU - Zhan, Ping

AU - Liu, Hongbing

AU - Lv, Tangfeng

AU - Miao, Liyun

AU - Min, Lingfeng

AU - Chen, Yu

AU - Zhang, Yu

AU - Wang, Feng

AU - Jiang, Zhansheng

AU - Lin, Gen

AU - Huang, Long

AU - Pu, Xingxiang

AU - Lin, Rongbo

AU - Liu, Weifeng

AU - Rao, Chuangzhou

AU - Lv, Dongqing

AU - Yu, Zongyang

AU - Shen, Peng

AU - Li, Xiaoyan

AU - Tang, Chuanhao

AU - Zhou, Chengzhi

AU - Zhang, Junping

AU - Xue, Junli

AU - Guo, Hui

AU - Chu, Qian

AU - Meng, Rui

AU - Wu, Jingxun

AU - Zhang, Rui

AU - Zhou, Jin

AU - Zhu, Zhengfei

AU - Li, Yongheng

AU - Qiu, Hong

AU - Xia, Fan

AU - Lu, Yuanyuan

AU - Chen, Xiaofeng

AU - Ge, Rui

AU - Dai, Enyong

AU - Han, Yu

AU - Zhang, Jian

AU - Ji, Yinghua

AU - Liang, Xianbin

AU - Zhang, Hongmei

AU - Ma, Xuelei

AU - Liu, Xuewen

AU - Yao, Yu

AU - Luo, Peng

AU - Pan, Weiwei

AU - Pang, Fei

AU - Wu, Fan

AU - Gu, Dejian

AU - Wang, Li

AU - Wang, Liping

AU - Zhu, Youcai

AU - Lin, Li

AU - Li, Weiwen

AU - Lin, Xinqing

AU - Cai, Jing

AU - Xu, Ling

AU - Li, Jisheng

AU - Jiao, Xiaodong

AU - Li, Kainan

AU - Wei, Jia

AU - Feng, Huijing

AU - Wang, Lin

AU - Du, Yingying

AU - Yao, Wang

AU - Shi, Xuefei

AU - Niu, Xiaomin

AU - Yuan, Dongmei

AU - Yao, Yanwen

AU - Zhang, Yinbin

AU - Song, Binbin

AU - Li, Wenfeng

AU - Fu, Jianfei

AU - Wang, Hong

AU - Ye, Mingxiang

AU - Wang, Dong

AU - Wang, Zhaofeng

AU - Ji, Qing

AU - Fang, Yuan

AU - Wei, Qing

AU - Wang, Zhen

AU - Wan, Bin

AU - Lv, Donglai

AU - Li, Xiaofeng

AU - Yang, Shengjie

AU - Kang, Jing

AU - Zhang, Jiatao

AU - Zhang, Chao

AU - Shi, Lin

AU - Wang, Yina

AU - Li, Bihui

AU - Zhang, Zhang

AU - Wang, Ke

AU - Liu, Zhefeng

AU - Yang, Nong

AU - Wu, Lin

AU - Chen, Xiaobing

AU - Jin, Gu

AU - Li, Zhongwu

AU - Li, Miao

AU - Wang, Guansong

AU - Wang, Jiandong

AU - Fang, Meiyu

AU - Fang, Yong

AU - Wang, Xiaojia

AU - Chen, Jing

AU - Zhang, Yiping

AU - Zhu, Xixu

AU - Shen, Yi

AU - Ma, Shenglin

AU - Wang, Biyun

AU - Si, Lu

AU - Song, Yong

AU - Lu, Yuanzhi

AU - Liu, Aijun

AU - Han, Yuchen

PY - 2026/2/17

Y1 - 2026/2/17

N2 - As an emerging biomarker, tumor mutational burden (TMB) has attracted increasing attention from clinicians in predicting the efficacy of tumor immunotherapy. Currently, TMB is detected primarily by whole-exome sequencing or targeted panel sequencing on high-throughput sequencing platforms. However, the lack of uniformity in detection methods, threshold settings, and reporting formats, as well as the significant differences in TMB values among different cancer types, have hindered the standardized application of this biomarker in clinical practice. This consensus focuses on the definition, standardization of detection, clinical significance, and limitations of TMB, and provides consensus recommendations for the clinical application of TMB in real-world practice in China. This consensus is aimed at helping clinicians and laboratory personnel understand the clinical significance and testing standards of TMB, promoting more accurate interpretation of test results, and improving patient care.

AB - As an emerging biomarker, tumor mutational burden (TMB) has attracted increasing attention from clinicians in predicting the efficacy of tumor immunotherapy. Currently, TMB is detected primarily by whole-exome sequencing or targeted panel sequencing on high-throughput sequencing platforms. However, the lack of uniformity in detection methods, threshold settings, and reporting formats, as well as the significant differences in TMB values among different cancer types, have hindered the standardized application of this biomarker in clinical practice. This consensus focuses on the definition, standardization of detection, clinical significance, and limitations of TMB, and provides consensus recommendations for the clinical application of TMB in real-world practice in China. This consensus is aimed at helping clinicians and laboratory personnel understand the clinical significance and testing standards of TMB, promoting more accurate interpretation of test results, and improving patient care.

KW - Biomarkers

KW - targeted panel sequencing

KW - tumor immunotherapy

KW - tumor mutational burden

KW - whole-exome sequencing

UR - https://www.scopus.com/pages/publications/105033345980

U2 - 10.20892/j.issn.2095-3941.2025.0351

DO - 10.20892/j.issn.2095-3941.2025.0351

M3 - 文章

C2 - 41704094

AN - SCOPUS:105033345980

SN - 2095-3941

VL - 23

JO - Cancer Biology and Medicine

JF - Cancer Biology and Medicine

IS - 2

ER -

Expert consensus on the detection and clinical application of tumor mutational burden

摘要

联合国可持续发展目标

访问文件

其它文件与链接

学术指纹

引用此