Experimental Study of Glaucoma Drug Delivery Across Cornea

Glaucoma is one of the diseases that cause blindness in the eye. Topical application is an effective method for the treatment of glaucoma, but the low permeability of the cornea limits the rapid transport of the drug to the recombinant tissue, so it is urgent to study the transmembrane transport properties of glaucoma drugs. ω=0.01, ω=0.05 two different mass fractions of the aqueous solution of pilocarpine as a glaucoma drug preparation, acting on the porcine cornea for drug permeability in vitro experiments. The experimental results show that: The growth rate of the drug concentration in the receiving group wasω=0.05 higher than that in the experimental group, and the growth rate of the drug concentration was proportional to the initial target concentration; The drug accumulation process is mainly composed of two stages of unsteady state and pseudo steady state. The function of drug accumulation and drug concentration, time, corneal thickness, and drug diffusion coefficient were obtained in the pseudo steady state; The diffusion coefficient of aqueous solution of pilocarpine across the cornea is about 2.47×10^-6 cm²/s. This paper is helpful to establish a mathematical description equation for transmembrane transport properties of glaucoma drugs in the future, thereby optimize the drug design of glaucoma drugs.