Electronic dura mater for long-term multimodal neural interfaces

Ivan R. Minev; Pavel Musienko; Arthur Hirsch; Quentin Barraud; Nikolaus Wenger; Eduardo Martin Moraud; Jérôme Gandar; Marco Capogrosso; Tomislav Milekovic; Léonie Asboth; Rafael Fajardo Torres; Nicolas Vachicouras; Qihan Liu; Natalia Pavlova; Simone Duis; Alexandre Larmagnac; Janos Vörös; Silvestro Micera; Zhigang Suo; Grégoire Courtine; Stéphanie P. Lacour

doi:10.1126/science.1260318

Electronic dura mater for long-term multimodal neural interfaces

Ivan R. Minev
, Pavel Musienko
, Arthur Hirsch
, Quentin Barraud
, Nikolaus Wenger
, Eduardo Martin Moraud
, Jérôme Gandar
, Marco Capogrosso
, Tomislav Milekovic
, Léonie Asboth
, Rafael Fajardo Torres
, Nicolas Vachicouras
, Qihan Liu
, Natalia Pavlova
, Simone Duis
, Alexandre Larmagnac
, Janos Vörös
, Silvestro Micera
, Zhigang Suo
, Grégoire Courtine

Stéphanie P. Lacour

Swiss Federal Institute of Technology Lausanne
Pavlov Institute of Physiology, Russian Academy of Sciences
Harvard University
Swiss Federal Institute of Technology Zurich
Sant'Anna School of Advanced Studies

科研成果: 期刊稿件 › 文章 › 同行评审

960 引用（Scopus）

摘要

The mechanical mismatch between soft neural tissues and stiff neural implants hinders the long-term performance of implantable neuroprostheses. Here, we designed and fabricated soft neural implants with the shape and elasticity of dura mater, the protective membrane of the brain and spinal cord. The electronic dura mater, which we call e-dura, embeds interconnects, electrodes, and chemotrodes that sustain millions of mechanical stretch cycles, electrical stimulation pulses, and chemical injections. These integrated modalities enable multiple neuroprosthetic applications. The soft implants extracted cortical states in freely behaving animals for brain-machine interface and delivered electrochemical spinal neuromodulation that restored locomotion after paralyzing spinal cord injury.

源语言	英语
页（从-至）	159-163
页数	5
期刊	Science
卷	347
期	6218
DOI	https://doi.org/10.1126/science.1260318
出版状态	已出版 - 9 1月 2015
已对外发布	是

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Minev, I. R., Musienko, P., Hirsch, A., Barraud, Q., Wenger, N., Moraud, E. M., Gandar, J., Capogrosso, M., Milekovic, T., Asboth, L., Torres, R. F., Vachicouras, N., Liu, Q., Pavlova, N., Duis, S., Larmagnac, A., Vörös, J., Micera, S., Suo, Z., ... Lacour, S. P. (2015). Electronic dura mater for long-term multimodal neural interfaces. Science, 347(6218), 159-163. https://doi.org/10.1126/science.1260318

@article{e6ebfa27f2a34994bb15e91cbfd9ca1a,

title = "Electronic dura mater for long-term multimodal neural interfaces",

abstract = "The mechanical mismatch between soft neural tissues and stiff neural implants hinders the long-term performance of implantable neuroprostheses. Here, we designed and fabricated soft neural implants with the shape and elasticity of dura mater, the protective membrane of the brain and spinal cord. The electronic dura mater, which we call e-dura, embeds interconnects, electrodes, and chemotrodes that sustain millions of mechanical stretch cycles, electrical stimulation pulses, and chemical injections. These integrated modalities enable multiple neuroprosthetic applications. The soft implants extracted cortical states in freely behaving animals for brain-machine interface and delivered electrochemical spinal neuromodulation that restored locomotion after paralyzing spinal cord injury.",

author = "Minev, \{Ivan R.\} and Pavel Musienko and Arthur Hirsch and Quentin Barraud and Nikolaus Wenger and Moraud, \{Eduardo Martin\} and J{\'e}r{\^o}me Gandar and Marco Capogrosso and Tomislav Milekovic and L{\'e}onie Asboth and Torres, \{Rafael Fajardo\} and Nicolas Vachicouras and Qihan Liu and Natalia Pavlova and Simone Duis and Alexandre Larmagnac and Janos V{\"o}r{\"o}s and Silvestro Micera and Zhigang Suo and Gr{\'e}goire Courtine and Lacour, \{St{\'e}phanie P.\}",

year = "2015",

month = jan,

day = "9",

doi = "10.1126/science.1260318",

language = "英语",

volume = "347",

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Minev, IR, Musienko, P, Hirsch, A, Barraud, Q, Wenger, N, Moraud, EM, Gandar, J, Capogrosso, M, Milekovic, T, Asboth, L, Torres, RF, Vachicouras, N, Liu, Q, Pavlova, N, Duis, S, Larmagnac, A, Vörös, J, Micera, S, Suo, Z, Courtine, G & Lacour, SP 2015, 'Electronic dura mater for long-term multimodal neural interfaces', Science, 卷 347, 号码 6218, 页码 159-163. https://doi.org/10.1126/science.1260318

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AU - Hirsch, Arthur

AU - Barraud, Quentin

AU - Wenger, Nikolaus

AU - Moraud, Eduardo Martin

AU - Gandar, Jérôme

AU - Capogrosso, Marco

AU - Milekovic, Tomislav

AU - Asboth, Léonie

AU - Torres, Rafael Fajardo

AU - Vachicouras, Nicolas

AU - Liu, Qihan

AU - Pavlova, Natalia

AU - Duis, Simone

AU - Larmagnac, Alexandre

AU - Vörös, Janos

AU - Micera, Silvestro

AU - Suo, Zhigang

AU - Courtine, Grégoire

AU - Lacour, Stéphanie P.

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Electronic dura mater for long-term multimodal neural interfaces

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